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Detection of P glycoprotein activity on normal and leukemic CD34+ cells.

Abstract：

:Rhodamine 123 is transported by the transmembrane efflux pump P glycoprotein (Pgp). We used this fluorescent dye to study multidrug resistance (MDR) activity in normal and leukemic CD34+ cells. These immature cells had a high degree of MDR activity. Among leukemic cells, CD34+ leukemias had significantly higher MDR activity as compared to CD34- leukemias. Heterogeneous results in cell subpopulations, however, indicate that prognosis should be interpreted in the light of MDR analysis.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Drenou B,Fardel O,Amiot L,Fauchet R

doi

10.1016/0145-2126(93)90159-i

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

1031-5

issue

12

eissn

0145-2126

issn

1873-5835

journal_volume

17

pub_type

杂志文章

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