Expression of functional markers in acute lymphoblastic leukemia.

abstract：:Granulocytic sarcoma (GS) is a rare extra-medullary tumor and usually involves the skin, soft tissue, and lymph nodes. GS is found in 8% of acute myeloid leukemia (AML) patients, especially patients with t(8;21)AML. It has been suggested that GS is a poor prognostic factor in t(8;21)AML. Compared to t(8;21)AML, GS is ...

journal_title：Leukemia research

authors： Fujieda A,Nishii K,Tamaru T,Otsuki S,Kobayashi K,Monma F,Ohishi K,Nakase K,Katayama N,Shiku H

更新日期：2006-08-01 00:00:00

abstract：:Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) were measured in normal human and in malignant lymphoid cells. Thymocytes had high ADA activity (21.2 +/- 6.8 10(3) nM/h/mg) and low PNP activity (1.2 +/- 0.6), whereas T peripheral blood lymphocytes (PBL) had low ADA activity (1.20 +/- 0.22) and high...

journal_title：Leukemia research

authors： Demeocq F,Viallard JL,Boumsell L,Richard Y,Chassagne J,Plagne R,Lemerle J,Bernard A

更新日期：1982-01-01 00:00:00

abstract：:Occupational and industrial exposures have been implicated in the etiology of leukemia, yet uncertainty remains regarding potential high risk occupations. We examined the associations between self-reported occupations and hobbies and acute leukemia risk using data from 811 cases and 637 controls participating in a cas...

journal_title：Leukemia research

authors： Terry PD,Shore DL,Rauscher GH,Sandler DP

更新日期：2005-10-01 00:00:00

abstract：:Chemosensitivity of purified AML blasts to daunomycin was examined under conditions of CSF stimulation and compared with clinical outcome of DNR combination chemotherapy. AML blasts from 16 patients were purified, incubated serum-free in the presence of optimal concentrations of a complete cocktail of IL-3, GM-CSF and...

journal_title：Leukemia research

authors： Santini V,Nooter K,Delwel R,Löwenberg B

更新日期：1990-01-01 00:00:00

abstract：:Thirty patients with high-risk myelodysplastic syndrome, defined as > 5% bone marrow blasts, were treated with a combination of oral all-trans-retinoic acid (45 mg/m2 daily) and subcutaneous AraC (10 mg/m2) on days 1-14 of each 28-35 day cycle repeated for 2-6 cycles. Complete remission lasting 9, 12, and 15 months wa...

journal_title：Leukemia research

authors： Letendre L,Noel P,White WL,Tefferi A,Litzow MR,Li CY,Schroeder G

更新日期：1999-09-01 00:00:00

abstract：:Although the earliest sites of hematopoietic cell and endothelial cell differentiation in the yolk sac blood islands were identified about 100 years ago, cells with hemangioblast properties have not yet been identified in vivo. Endothelial cells differentiate from angioblasts in the embryo and from endothelial progeni...

journal_title：Leukemia research

authors： Ribatti D

更新日期：2007-04-01 00:00:00

abstract：:Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid differentiation of K562 cells. During this erythroid differentiation, c-Myc and cyclin D1 transcripts are transiently downregulated. Accordingly, we studied the effect of cyclin D1 overexpression on erythroid differentiation. After treatment with 250 nM...

journal_title：Leukemia research

authors： Kawano T,Horiguchi-Yamada J,Saito S,Iwase S,Furukawa Y,Kano Y,Yamada H

更新日期：2004-06-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a group of clonally-acquired blood disorders characterized by ineffective hematopoiesis leading to cytopenias. Red blood cell transfusions are an important component of supportive care in patients with MDS. Prolonged exposure to transfusions can lead to iron overload, which results ...

journal_title：Leukemia research

authors： Angelucci E,Cianciulli P,Finelli C,Mecucci C,Voso MT,Tura S

更新日期：2017-11-01 00:00:00

abstract：:Feulgen-DNA cytophotometry and 3H-thymidine autoradiography were used to evaluate therapeutic cytapheresis effects on cell cycle distributions of peripheral blood leukemic cells in 15 acute leukemia, 5 CML and 8 CLL patients and of bone marrow erythroblasts in 18 PV patients. Both individual cytapheresis procedures an...

journal_title：Leukemia research

authors： Kotelnikov VM,Kasatkina VV,Dultsina SM,Sarytcheva TG,Kalinin NN,Kovaleva LG,Poljanskaja AM,Isajev VG,Khoroshko ND,Lishmanova NG

更新日期：1987-01-01 00:00:00

abstract：:There is a significant need for improved therapeutics in older patients with acute leukemia. Camidanlumab tesirine is an antibody-drug conjugate against CD25, an antigen expressed in several malignancies, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). This open-label, dose-escalation an...

journal_title：Leukemia research

authors： Goldberg AD,Atallah E,Rizzieri D,Walter RB,Chung KY,Spira A,Stock W,Tallman MS,Cruz HG,Boni J,Havenith KEG,Chao G,Feingold JM,Wuerthner J,Solh M

更新日期：2020-08-01 00:00:00

abstract：:N-Propyl-N-nitrosourea (PNU) was proved to be a strong leukemogen, which induces myelogenous leukemia or thymic lymphoma in rats. BUF/Mna rats and F344 rats were the strain most susceptible to thymic lymphomagenic activity of PNU. In addition, F1 rats between BUF/Mna and WKY rats were also susceptible to PNU-lymphomag...

journal_title：Leukemia research

authors： Ogiu T,Utsumi KR,Fukami H,Matsuyama M

更新日期：1988-01-01 00:00:00

abstract：:Adults with acute lymphoblastic leukemia (ALL) in first complete remission (CR1) may be treated either with ongoing systemic chemotherapy or with allogeneic hematopoietic cell transplantation (alloHCT). Despite the presence of phase III trials to support clinical decision-making, we hypothesized that physicians who tr...

journal_title：Leukemia research

authors： Paulson K,Szwajcer D,Raymond CB,Seftel MD

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders, with very different prognosis in given individuals; age and comorbidities are emerging as relevant patient-related factors influencing clinical outcome in MDS. Our aim was to evaluate the impact of age, comorbidities and disease s...

journal_title：Leukemia research

authors： Balleari E,Salvetti C,Del Corso L,Filiberti R,Bacigalupo A,Bellodi A,Beltrami G,Bergamaschi M,Berisso G,Calzamiglia T,Carella AM,Cavalleri M,Da Col A,Favorini S,Forni GL,Goretti R,Miglino M,Mitscheuning L,Molinari E,

更新日期：2015-08-01 00:00:00

abstract：:The genes for the CDK4/6-inhibitors p16INK4A/MTS1 and p15INK4B/MTS2 are frequently deleted in hematological malignancies. A new member of this family of CDK4/6 inhibitors is p18. In order to assess p18 growth-suppressor gene alterations in hematological neoplasms, we investigated 31 lymphoma and leukemia cell lines by...

journal_title：Leukemia research

authors： Siebert R,Willers CP,Fosså A,Kloke O,Nowrousian MR,Seeber S,Opalka B

更新日期：1996-02-01 00:00:00

abstract：:Immunoglobulin gene rearrangements can be used as genetic markers of clonality in the study of B-cell populations [4]. We have therefore analysed the structure and expression of heavy and light chain immunoglobulin genes in lymphocytes of a patient with chronic lymphocytic leukemia, where we found both k and lambda pr...

journal_title：Leukemia research

authors： del Senno L,Gandini D,Gambari R,Lanza F,Tomasi P,Castoldi G

更新日期：1987-01-01 00:00:00

abstract：:The effect of mesna on intracellular accumulation of cytosine arabinoside (Ara-C) in murine normal and neoplastic lymphocytes was studied. Simultaneous exposure of cells to mesna at concentrations ranging from 0.25 to 1.0 mM and 3H-Ara-C (40.0 nM) resulted in a strong inhibition of Ara-C uptake in normal lymphocytes. ...

journal_title：Leukemia research

authors： Jastrzebski Z,Czyzewska-Szafran H,Remiszewska M,Côte-Rozanes C

更新日期：1993-09-01 00:00:00

abstract：:This retrospective study of the thrombocythemia Italian registry (RIT) documented that 71 (30.6%) out of 232 ET patients experienced 88 cardiovascular adverse events (CV-AEs) during anagrelide treatment (522 pt-y). The rate of CV-AEs was: 24.1% for palpitations, 4.3% for angina, 3.5% for arterial hypertension, 3.0% fo...

journal_title：Leukemia research

authors： Gugliotta L,Tieghi A,Tortorella G,Scalzulli PR,Ciancia R,Lunghi M,Cacciola E,Cacciola R,Candoni A,Crugnola M,Codeluppi K,Usala E,Specchia G,Martinelli V,Palmieri F,Pierri I,Liberati AM,Iurlo A,Grossi A,Vannucchi AM

更新日期：2011-12-01 00:00:00

abstract：:Inosine 5'-monophosphate (IMP) dehydrogenase catalyzes the rate-limiting reaction of guanine nucleotide biosynthesis and has been implicated in the reaction of cell growth and differentiation. We investigated the ability of mycophenolate mofetil, a prodrug of mycophenolic acid, to induce differentiation in HL-60 and U...

journal_title：Leukemia research

authors： Inai K,Tsutani H,Yamauchi T,Fukushima T,Iwasaki H,Imamura S,Wano Y,Nemoto Y,Naiki H,Ueda T

更新日期：2000-09-01 00:00:00

abstract：:The immunologic phenotype of the lymphocytes of 100 patients with chronic lymphocytic leukaemia (CLL) was investigated. Peripheral blood lymphocytes (PBL) were examined in all cases; in 46 patients with lymphadenopathy, a lymph node was biopsied and the histologic and immunologic patterns were assessed: 24 had a lymph...

journal_title：Leukemia research

authors： Resegotti L,Palestro G,Novero D,Micca FB,Godio L,Pistone M,Garnero M,Levis A,Stramignoni A

更新日期：1987-01-01 00:00:00

abstract：:Leukemic blasts of two patients with acute leukemia exhibited similar characteristics. They were heterogeneous in size with a diameter of 14-30 microns in smears and unclassifiable by morphological, cytochemical, immunophenotypic and ultrastructural examinations. Cytogenetic examinations of both revealed a near-tetrap...

journal_title：Leukemia research

authors： Lemez P,Jelínek J,Michalová K,Koubek K,Schwarz J,Malasková V,Rypácková B,Jirásek A,Brezinová J,Hrabánek J

更新日期：1994-07-01 00:00:00

abstract：:To increase our knowledge of the pathogenesis of tumour recurrence, cell membrane phenotypes were determined on bone marrow and extramedullary tumour cells at diagnosis and at relapse in 24 children with lymphoid malignancies. There were 19 patients with acute lymphoblastic leukemia and five with non-Hodgkin's lymphom...

journal_title：Leukemia research

authors： Lauer S,Piaskowski V,Camitta B,Casper J

更新日期：1982-01-01 00:00:00

abstract：:The MYBL2 gene encodes a transcription factor implicated in cell proliferation and maturation whose amplification or overexpression has been associated with different human malignancies, suggesting that it could be implicated in tumorigenesis. We analyzed MYBL2 expression and its prognostic value in 291 patients with ...

journal_title：Leukemia research

authors： Fuster O,Llop M,Dolz S,García P,Such E,Ibáñez M,Luna I,Gómez I,López M,Cervera J,Montesinos P,Moscardó F,Cordón L,Solves P,de Juan I,Palanca S,Bolufer P,Sanz MÁ,Barragán E

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIMS:Jumping translocations are rare cytogenetic aberrations in haematological malignancies, the pathogenesis of which remains to be fully characterised. We investigated the mechanism of formation of jumping translocations in a case of adult common acute lymphoblastic leukaemia (ALL) positive for the Ph tran...

journal_title：Leukemia research

authors： Wan TS,Ma SK,Chow EY,Li YH,Lin SY,Chan LC

更新日期：2004-10-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is rare in Asians living in Asia and possibly in US Asians. In contrast, CLL is the most common leukemia in whites. The basis for this ethnic and geographic variation is unknown. We compared average annual age-adjusted incidence rates (AAIR) of CLL diagnosed from 1972 to 1995 among L...

journal_title：Leukemia research

authors： Gale RP,Cozen W,Goodman MT,Wang FF,Bernstein L

更新日期：2000-08-01 00:00:00

abstract：:Semenogelin (SEMG) I is a Cancer-Testis (CT) antigen that we have found to be expressed in myeloma cells. In this study, we set out to determine whether the expression of SEMG I could be upregulated pharmacologically. We found that SEMG I expression in myeloma cells can be upregulated by 5-azacytidine, IL-4 and IL-6. ...

journal_title：Leukemia research

authors： Zhang Y,Wang Z,Zhang J,Farmer B,Lim SH

更新日期：2008-12-01 00:00:00

abstract：:A retrospective analysis of the relationship between the initial classification according to either FAB or WHO criteria, the presence of risk factors and the type of therapy including stem cell transplantation (SCT) on the survival was performed in a group of 106 patients with primary myelodysplastic syndrome (MDS) of...

journal_title：Leukemia research

authors： Cermák J,Vítek A,Michalová K

更新日期：2004-06-01 00:00:00

abstract：:It has been suggested that acidic isoferritins play a major role in the regulation of human granulocyte-macrophage (CFU-GM) proliferation. Such regulatory isoferritins are said to occur in some human tissues including both leukaemic and normal leucocytes, and certain established cell lines. They are glycosylated and b...

journal_title：Leukemia research

authors： Wyllie F,Jacobs A,Waradanukul K,Worwood M,Wagstaff M

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Chronic Myeloid Leukemia (CML) is characterized by the overproduction of BCR-ABL, a tyrosine kinase with constitutive activity, in which the majority of CML patients have e13a2 or e14a2 transcripts. Reckoned the possible associations between the hematologic and molecular features of the disease, a profound u...

journal_title：Leukemia research

authors： Ghalesardi OK,Khosravi A,Azizi E,Ahmadi SE,Hajifathali A,Bonakchi H,Shahidi M

更新日期：2021-01-19 00:00:00

abstract：:Although clinical experience and in vitro data provide evidence of an anti-leukemic activity of T cells, there are few examples of recognition of leukemic cells by tumor-specific T cells in vitro. Tumor antigens encoded by the MAGE genes are useful tools to study this recognition. We tested the sensitivity to recognit...

journal_title：Leukemia research

authors： Chambost H,Collette Y,Dutartre H,Thuret I,Olive D

更新日期：2000-10-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) in children has been reported to be associated with various constitutional anomalies; however, it has not been described previously in patients with Griscelli syndrome (GS). In this report, we present a case with GS and refractory anemia with an excess of blasts. We believe that careful ...

journal_title：Leukemia research

authors： Cetin M,Hiçsönmez G,Göğüş S

更新日期：1998-09-01 00:00:00