Synergistic effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.

abstract：:Fifty-three patients with Ph positive chronic myeloid leukaemia in blastic phase were studied. Additional abnormalities were found in 29 (55%) patients and were more common in myeloid (64%) than lymphoid (45%) blast crisis. The most frequent were +Ph (32%), +8 (28%), +19 (19%), +20 (9%) and +21 (9%). i(17q) (9%) was a...

journal_title：Leukemia research

authors： Nanjangud G,Kadam PR,Saikia T,Bhisey AN,Kumar A,Gopal R,Chopra H,Nair CN,Advani SH

更新日期：1994-05-01 00:00:00

abstract：:Effects of the HDAC inhibitor LBH-589 (panobinostat) on fludarabine lethality toward acute myeloid leukemia (AML) cells were examined in vitro and in vivo. LBH-589 pretreatment sensitized U937, HL-60, and primary leukemia cells to fludarabine while blocking NF-κB activation accompanied by XIAP down-regulation and JNK ...

journal_title：Leukemia research

authors： Rosato R,Hock S,Dent P,Dai Y,Grant S

更新日期：2012-04-01 00:00:00

abstract：:In a patient affected with chronic lymphocytic leukemia with lymphocyte surface mu and kappa determinants and vacuolated bone marrow plasma cells, the serum contained polymers of a truncated mu chain and normal-sized kappa chains. These light chains were present as monomers and covalent dimers in studies performed und...

journal_title：Leukemia research

authors： Cogné M,Aucouturier P,Brizard A,Dreyfus B,Duarte F,Preud'homme JL

更新日期：1993-06-01 00:00:00

abstract：:To elucidate the biological characteristics of chronic myelogenous leukemia (CML) cells, we observed morphological and functional changes of CML cells during primary long-term culture, in which their morphology changed to that of myofibroblasts with similar molecular characteristics to the parental CML cells including...

journal_title：Leukemia research

authors： Shirasaki R,Tashiro H,Mizutani-Noguchi M,Kawasugi K,Shirafuji N

更新日期：2011-05-01 00:00:00

abstract：:K-562 is described as a pluripotent leukemic cell line which expresses a diversity of hematopoietic cell differentiation antigens. With the use of monoclonal antibodies (MoAb), we show that the expression of these antigens is either "modulated", i.e. they are not expressed in early logarithmic growth but are expressed...

journal_title：Leukemia research

authors： Ichiki AT,Lozzio CB,Bamberger EG,Lucas PB,Wust CJ,Fuhr JE

更新日期：1987-01-01 00:00:00

abstract：:The expression of various proto-oncogenes in primary culture of lymphocytes from peripheral blood of bovine with chronic lymphocytic leukemia (CLL) was studied. Cellular proto-oncogenes encode proteins that propagate growth, differentiation or apoptosis signals from cell membrane to nucleus. The proliferation and diff...

journal_title：Leukemia research

authors： Kalvelyte AV,Pabrezaite LC

更新日期：1998-02-01 00:00:00

abstract：:The efficiency of gene transfer into human leukemia cell lines by electroporation was investigated. For both transient expression (beta-galactosidase gene) and stable transformation (neomycin resistance gene), the transfer efficiency into leukemia cell lines using a square wave pulse was superior to that using an expo...

journal_title：Leukemia research

authors： Takahashi M,Furukawa T,Saitoh H,Aoki A,Koike T,Moriyama Y,Shibata A

更新日期：1991-01-01 00:00:00

abstract：:A novel bone biopsy technique was used to generate a robust stromal cell system to study how stroma modulates CLL B-cell apoptosis and how the leukemic cell-stromal interaction influences secretion of vascular factors. Marrow stromal elements (MSE) rescued CLL B-cells from both spontaneous and drug induced apoptosis, ...

journal_title：Leukemia research

authors： Kay NE,Shanafelt TD,Strege AK,Lee YK,Bone ND,Raza A

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders, with very different prognosis in given individuals; age and comorbidities are emerging as relevant patient-related factors influencing clinical outcome in MDS. Our aim was to evaluate the impact of age, comorbidities and disease s...

journal_title：Leukemia research

authors： Balleari E,Salvetti C,Del Corso L,Filiberti R,Bacigalupo A,Bellodi A,Beltrami G,Bergamaschi M,Berisso G,Calzamiglia T,Carella AM,Cavalleri M,Da Col A,Favorini S,Forni GL,Goretti R,Miglino M,Mitscheuning L,Molinari E,

更新日期：2015-08-01 00:00:00

abstract：:Some peripheral blood clonogenic T-cells from patients with T-cell malignancies can generate colonies in methylcellulose in the absence of added growth factors or mitogen stimulation (T-CFCs). T-CFC from these patients were also able to form colonies in semi-solid media in the presence of added growth factors (T-CFCi)...

journal_title：Leukemia research

authors： Georgoulias V,Auclair H,Jasmin C

更新日期：1984-01-01 00:00:00

abstract：:We hypothesized that the lipid second messenger, ceramide, and microtubule-directed chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our studies demonstrated that simultaneous treatment of Jurkat cells with paclitaxel and ceramide enhanced paclitaxel-induced cell growth inhibition. Cell ...

journal_title：Leukemia research

authors： Myrick D,Blackinton D,Klostergaard J,Kouttab N,Maizel A,Wanebo H,Mehta S

更新日期：1999-06-01 00:00:00

abstract：:The usefulness of a new method to detect B-cell monoclonality named VR, which is a combination of the digestion with restriction enzymes and vectorette PCR, in aspiration biopsy-nucleic acid diagnosis (ABND) of thyroid malignant lymphoma was investigated. ABND was performed in 12 patients in whom malignant lymphoma wa...

journal_title：Leukemia research

authors： Takano T,Asahi S,Matsuzuka F,Hidaka Y,Yoshida H,Miyauchi A

更新日期：2008-01-01 00:00:00

abstract：:240 patients with MDS studied cytogenetically at diagnosis between 1981 and 1990 were followed until death or until April 1992 to evaluate the prognostic significance of FAB classification, age and karyotype. 61 patients (25.4%) subsequently transformed into AML and 176 (73.3%) died during the follow-up period. Patien...

journal_title：Leukemia research

authors： Musilová J,Michalová K,Zemanová Z,Neuwirthová R,Dohnalová A

更新日期：1995-05-01 00:00:00

abstract：:Thirty patients with high-risk myelodysplastic syndrome, defined as > 5% bone marrow blasts, were treated with a combination of oral all-trans-retinoic acid (45 mg/m2 daily) and subcutaneous AraC (10 mg/m2) on days 1-14 of each 28-35 day cycle repeated for 2-6 cycles. Complete remission lasting 9, 12, and 15 months wa...

journal_title：Leukemia research

authors： Letendre L,Noel P,White WL,Tefferi A,Litzow MR,Li CY,Schroeder G

更新日期：1999-09-01 00:00:00

abstract：:We describe the properties of three monoclonal antibodies (McAbs) (21H73, 37G7 and 49C12) against K562 cell surface antigens correlated with differentiation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA). Each of the McAbs immunoprecipitated K562 cell surface antigen with molecular weight (MW) of approximately...

journal_title：Leukemia research

authors： Kubota Y,Tanaka T,Irino S

更新日期：1991-01-01 00:00:00

abstract：:The chemicals 6-mercaptopurine (6-MP) and methotrexate (MTX) are the cornerstones in the maintenance treatment of acute lymphoblastic leukemia. The intracellular metabolism of 6-MP to 6-thioguanosine nucleotides (TGN) via 6-thioinosine 5'-monophosphate (TIMP) is crucial for its cytotoxic effect. MTX inhibits purine de...

journal_title：Leukemia research

authors： Liliemark J,Pettersson B,Peterson C

更新日期：1992-01-01 00:00:00

abstract：:The basis of intrinsic resistance of blasts from patients with acute non-lymphocytic leukemia (ANLL) to methotrexate was studied. MTX polyglutamate formation was measured in blast cells from 19 patients with ANLL and in 7 pediatric patients with acute lymphocytic leukemia (ALL), after in vitro incubation for 24 h with...

journal_title：Leukemia research

authors： Lin JT,Tong WP,Trippett TM,Niedzwiecki D,Tao Y,Tan C,Steinherz P,Schweitzer BI,Bertino JR

更新日期：1991-01-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 (1,25D) induces differentiation of myeloid leukemia cells, but resistant cells are also encountered. We studied the mechanistic basis for the resistance in a model system using enhancers of 1,25D, the antioxidant carnosic acid and a kinase inhibitor SB202190. Knock-down (KD) of JNK2p54 unexpec...

journal_title：Leukemia research

authors： Chen-Deutsch X,Garay E,Zhang J,Harrison JS,Studzinski GP

更新日期：2009-10-01 00:00:00

abstract：:Appropriate treatment for nonreactive thrombocytosis resulting from a myeloproliferative disorder (MPD) is surrounded by controversy. Although few doubt the association of thrombocytosis with increased risk for life-threatening events such as thrombosis or hemorrhage, or the association between clonal myeloproliferati...

journal_title：Leukemia research

authors： Fruchtman SM,Petitt RM,Gilbert HS,Fiddler G,Lyne A,Anagrelide Study Group.

更新日期：2005-05-01 00:00:00

abstract：:To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher ...

journal_title：Leukemia research

authors： Latagliata R,Breccia M,Castagnetti F,Stagno F,Luciano L,Gozzini A,Ulisciani S,Cavazzini F,Annunziata M,Sorà F,Rossi AR,Pregno P,Montefusco E,Abruzzese E,Crisà E,Musto P,Tiribelli M,Binotto G,Occhini U,Feo C,Vigner

更新日期：2011-09-01 00:00:00

abstract：:The thymic stroma has long been implicated in AKR thymic leukaemia. In this study an extensive panel of monoclonal antibodies was used to investigate changes in the AKR thymic microenvironment, in parallel with thymocyte differentiation of normal (2 month), preleukaemic (5-7 month) and leukaemic (> 7 month) mice. We f...

journal_title：Leukemia research

authors： Davey GM,Tucek-Szabo CL,Boyd RL

更新日期：1996-10-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic malignancies characterized by ineffective hematopoiesis, progressive bone marrow (BM) failure, cytogenetic and molecular abnormalities, and variable risk of progression to acute myeloid leukemia (AML). The BM microenvironment in MDS plays ...

journal_title：Leukemia research

authors： Cogle CR,Saki N,Khodadi E,Li J,Shahjahani M,Azizidoost S

更新日期：2015-10-01 00:00:00

abstract：:T-cell leukemias were induced in adult BDF1 mice by a single i.v. injection of methylnitrosourea (MNU). Leukemogenesis was delayed by a single or repeated injections of hydrocortisone (HC) after MNU and also when HC was given one day before MNU. Enhancement of leukemogenesis was seen in experiments with 10 and 14 days...

journal_title：Leukemia research

authors： Seidel HJ,Kreja L

更新日期：1985-01-01 00:00:00

abstract：:The aims were to investigate the feasibility of imatinib mesylate (IM) discontinuation in chronic myeloid leukemia patients who were initially treated with IM and achieved complete molecular response (CMR). Fourteen patients were included. Ten were relapsed within 9.5 months after discontinuation of IM. All 7 patients...

journal_title：Leukemia research

authors： Yhim HY,Lee NR,Song EK,Yim CY,Jeon SY,Shin S,Kim JA,Kim HS,Cho EH,Kwak JY

更新日期：2012-06-01 00:00:00

abstract：:Imatinib mesylate, a Bcr/Abl tyrosine kinase inhibitor, is widely used in treating chronic myeloid leukemia. However, drug-resistance of leukemia cells becomes an emergent problem. Herein, various flavonoids were screened for applicability in leukemia treatment, and 3-hydroxyflavone (3-HF) was found to be most effecti...

journal_title：Leukemia research

authors： Kim JH,Song M,Kang GH,Lee ER,Choi HY,Lee C,Kim JH,Kim Y,Koo BN,Cho SG

更新日期：2012-09-01 00:00:00

abstract：:Internal tandem duplications (ITDs) of the FLT3 gene occur in approximately 20-30% of acute myeloid leukemia (AML) patients. We investigated if FLT3 ITDs could be used as minimal residual disease (MRD) markers for AML patients. Patient-specific polymerase chain reaction (PCR) assays for FLT3 ITDs were developed for fo...

journal_title：Leukemia research

authors： Stirewalt DL,Willman CL,Radich JP

更新日期：2001-12-01 00:00:00

abstract：:Despite initial remissions, most patients with Ph chromosome positive (Ph(+)) acute leukemia (AL) become refractory to tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib. This study was designed to determine if targeting the interleukin-3 receptor (IL-3R) with a diphtheria toxin fusion protein (DT(388)IL...

journal_title：Leukemia research

authors： Kim HP,Frankel AE,Hogge DE

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Chromosomal aberrations at the ETV6 gene locus on 12p13.2 are common in bone marrow samples involved by blastic plasmacytoid dendritic cell neoplasm (BPDCN). However, their pathogenic role, incidence in cutaneous BPDCN lesions, and clinical significance have not been assessed systematically. RESULTS:The stu...

journal_title：Leukemia research

authors： Tang Z,Li Y,Wang W,Yin CC,Tang G,Aung PP,Hu S,Lu X,Toruner GA,Medeiros LJ,Khoury JD

更新日期：2018-10-01 00:00:00

abstract：:We describe here a unique case of therapy-related myelodysplastic syndrome (t-MDS) with inv(16)(p13q22) after autologous stem cell transplantation for lymphoma. The rare and smallest I type CBFbeta/MYH11 fusion transcript with a breakpoint at nucleotide 399 of CBFbeta and at nucleotide 2134 of MYH11 was detected in th...

journal_title：Leukemia research

authors： Yamamoto K,Nishikawa S,Minagawa K,Yakushijin K,Okamura A,Matsui T

更新日期：2006-03-01 00:00:00

abstract：:Apoptosis resistance is an important mechanisms of drug resistance mediated by bone marrow stromal cells (BMSCs). BMSCs influence tumor cells survival through several mechanisms including direct cell-cell contact and the effects of soluble factors. In this research we investigated the role of X-linked inhibitor of apo...

journal_title：Leukemia research

authors： Wang X,Wang C,Yan SK,Gao YR

更新日期：2007-08-01 00:00:00