XIAP is upregulated in HL-60 cells cocultured with stromal cells by direct cell contact.

abstract：:We monitored DLI treatment of 13 post-SCT relapses using quantitative competitive (QC) RT-PCR for BCR-ABL (sensitivity 10(-5)) and compared responses to DLI alone and DLI in combination with interferon-alpha (IFN). Ten relapses (one blast crisis, five cytogenetic and four molecular) were treated with DLI+IFN, three re...

journal_title：Leukemia research

authors： Moravcová J,Nádvorníková S,Zmeková V,Michalová K,Brezinová J,Lukásová M,Vítek A,Hrabánek J,Gasová Z,Sedlácek P,Starý J

更新日期：2003-08-01 00:00:00

abstract：:This 5-year, prospective registry enrolled 600 lower-risk MDS patients (pts) with transfusional iron overload. Clinical outcomes were compared between chelated and nonchelated pts. At baseline, cardiovascular comorbidities were more common in non-chelated pts, and MDS therapy was more common in chelated pts. At 24 mon...

journal_title：Leukemia research

authors： Lyons RM,Marek BJ,Paley C,Esposito J,Garbo L,DiBella N,Garcia-Manero G

更新日期：2014-02-01 00:00:00

abstract：:The functional behavior of hematopoietic stem cell (HSC) and progenitors in chronic myelomonocytic leukemia (CMML) and on disease progression is little known. We performed cell proliferation, apoptosis, hematopoietic colony forming/replating and differentiation potential studies in the purified subpopulations of Lin(-...

journal_title：Leukemia research

authors： Sun Q,So CC,Yip SF,Wan TS,Ma SK,Chan LC

更新日期：2008-09-01 00:00:00

abstract：:In this study we investigated the Ara-CTP-forming capacity of leukemic cells in different phases of the cell cycle. Cells from two leukemic cell lines and leukemic bone marrow cells from patients and rats (BNML model) with acute myelocytic leukemia were separated according to cell cycle phase by means of an albumin de...

journal_title：Leukemia research

authors： Richel DJ,Colly LP,Arentsen-Honders MW,Starrenburg CW,Willemze R

更新日期：1990-01-01 00:00:00

abstract：:Cases of leukemia associated with Turner syndrome (TS) are rare. Here we report three TS patients with leukemia including one case of T-large granular lymphocyte leukemia (T-LGL), one rare case of coexistence of chronic lymphocytic leukemia (CLL) and idiopathic myelofibrosis (IMF) and one case of a patient with AML-M2...

journal_title：Leukemia research

authors： Manola KN,Sambani C,Karakasis D,Kalliakosta G,Harhalakis N,Papaioannou M

更新日期：2008-03-01 00:00:00

abstract：:In-vitro infection of normal human lymphocytes with HTLV-I (human T-cell lymphotropic retrovirus type I) has been carried out to study the target cell specificity and the kinetics of infection. Cord blood (CBL) and adult peripheral blood lymphocytes (PBL) have been co-cultivated with irradiated HTLV-I donor cells (MT2...

journal_title：Leukemia research

authors： Del Mistro A,De Rossi A,Aldovini A,Salmi R,Chieco-Bianchi L

更新日期：1986-01-01 00:00:00

abstract：:Chronic Lymphocytic Leukemia B cells (CLL) are malignant cells which retain at least some functions of normal B cells. Paramount amongst the latter is that when such cells are appropriately stimulated, they are able to present antigens, including any potential tumor antigens, making them excellent choices as a candida...

journal_title：Leukemia research

authors： Zhu F,Khatri I,Spaner D,Gorczynski RM

更新日期：2018-05-01 00:00:00

abstract：:We report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. The cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at di...

journal_title：Leukemia research

authors： Dalla Torre CA,de Martino Lee ML,Yoshimoto M,Lopes LF,Melo LN,Caminada de Toledo SR,Duffles Andrade JA

更新日期：2002-06-01 00:00:00

abstract：:Chromosomal changes are necessary in determining the classification, prognosis and using the appropriate therapeutic regimen in acute leukemia. Isochromosomes are uncommon chromosome aberations in childhood acute lymphoblastic leukemia (ALL) and the effect of i(9q) is not well established. We present an 8-year-old mal...

journal_title：Leukemia research

authors： Cogulu O,Karapinar DY,Karaca E,Aydinok Y,Ozkinay F

更新日期：2006-11-01 00:00:00

abstract：:Immunoglobulin gene rearrangements can be used as genetic markers of clonality in the study of B-cell populations [4]. We have therefore analysed the structure and expression of heavy and light chain immunoglobulin genes in lymphocytes of a patient with chronic lymphocytic leukemia, where we found both k and lambda pr...

journal_title：Leukemia research

authors： del Senno L,Gandini D,Gambari R,Lanza F,Tomasi P,Castoldi G

更新日期：1987-01-01 00:00:00

abstract：:DNA aneuploidy has been used as a genetic marker of malignancy in multiple myeloma (MM). CD38 and CD138 expression and absence of CD22 and CD19 may define plasmacells (PC). Several authors support evidences of circulating plasmacells, and their role in relapse after autologous stem cell transplantation has been hypoth...

journal_title：Leukemia research

authors： Santonocito AM,Consoli U,Bagnato S,Milone G,Palumbo GA,Di Raimondo F,Stagno F,Guglielmo P,Giustolisi R

更新日期：2004-05-01 00:00:00

abstract：:We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and...

journal_title：Leukemia research

authors： Altman JK,Rademaker A,Cull E,Weitner BB,Ofran Y,Rosenblat TL,Haidau A,Park JH,Ram SL,Orsini JM Jr,Sandhu S,Catchatourian R,Trifilio SM,Adel NG,Frankfurt O,Stein EM,Mallios G,Deblasio T,Jurcic JG,Nimer S,Peterson L

更新日期：2013-09-01 00:00:00

abstract：:The tumor promoting agent TPA (phorbol ester; 1.6 X 10(-8)M) was used to induce the differentiation in vitro of B-chronic lymphocytic leukemia (B-CLL) cells from 14 untreated patients. The uninduced phenotype was SIg+, Mrbc+, RFT-1+, RFA-4-, FMC7-. After 72 h incubation with TPA, B-CLL cells became RFA-4+, FMC7+ and l...

journal_title：Leukemia research

authors： Caligaris-Cappio F,Janossy G,Campana D,Chilosi M,Bergui L,Foà R,Delia D,Giubellino MC,Preda P,Gobbi M

更新日期：1984-01-01 00:00:00

abstract：:This study examined the immunoregulatory role of recombinant interleukin 4 (IL-4), also known as B-cell stimulating factor 1, on the generation of cytotoxic effector cells from normal and leukaemic human blood mononuclear cells. When tested on cells from normal individuals, the addition of IL-4 to mixed lymphocyte cul...

journal_title：Leukemia research

authors： Jin BQ,Lopez AF,Gillis S,Juttner CA,Vadas MA,Burns GF

更新日期：1989-01-01 00:00:00

abstract：:K-562 is described as a pluripotent leukemic cell line which expresses a diversity of hematopoietic cell differentiation antigens. With the use of monoclonal antibodies (MoAb), we show that the expression of these antigens is either "modulated", i.e. they are not expressed in early logarithmic growth but are expressed...

journal_title：Leukemia research

authors： Ichiki AT,Lozzio CB,Bamberger EG,Lucas PB,Wust CJ,Fuhr JE

更新日期：1987-01-01 00:00:00

abstract：:Hemopoietic responses were studied in splenectomized mice after transplantation of the hemopoietic colony stimulating activity producing leukemia, L8313. In non-splenectomized mice, the number of peripheral leukocytes was elevated to 4 x 10(5)/mm3 after transplantation. In contrast, it was below 1.7 x 10(4)/mm3 in spl...

journal_title：Leukemia research

authors： Sawada H,Sugimoto K,Aramaki K,Mori KJ

更新日期：1989-01-01 00:00:00

abstract：:Diagnosis of MDS has changed during the last years because of the 2008 WHO classification. Complete blood cell count (CBC) is a very important tool both for diagnosis of MDS. The aim of this study was to evaluate if it is possible to use the abnormal signals produced by dysplastic cells to produce a flag "dysplasia" a...

journal_title：Leukemia research

authors： Rocco V,Maconi M,Gioia M,Silvestri MG,Tanca D,Catalano T,Avino D,Di Palma A,Rovetti A,Danise P

更新日期：2011-12-01 00:00:00

abstract：:Leukemic cell apoptosis may be enhanced by appropriate oxidative stress. We report here the mechanism of Jurkat cell apoptosis by monochloramine (NH(2)Cl), a neutrophil-derived oxidant. NH(2)Cl induced caspase-dependent apoptosis, which was preceded by cytochrome c and Smac/Diablo release from mitochondria. Within 10m...

journal_title：Leukemia research

authors： Ogino T,Ozaki M,Hosako M,Omori M,Okada S,Matsukawa A

更新日期：2009-01-01 00:00:00

abstract：:Argininosuccinate synthetase (ASS) is a ATP-dependent and rate-limiting enzyme of the urea cycle which catalyzes L-citrulline to L-arginine in combination with argininosuccinate lyase (ASL). We demonstrate here that (a) human normal T and B lymphocytes did not express ASS activity, (b) however, three adult T leukemia ...

journal_title：Leukemia research

authors： Sugimura K,Kimura T,Arakawa H,Ohno T,Wada Y,Kimura Y,Saheki T,Azuma I

更新日期：1990-01-01 00:00:00

abstract：:We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m(2) q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-r...

journal_title：Leukemia research

authors： Hassanein M,Atenafu EG,Schuh AC,Yee KW,Minden MD,Schimmer AD,Gupta V,Brandwein JM

更新日期：2013-05-01 00:00:00

abstract：:Using a short term liquid system we have shown that blood from some patients with primary myelofibrosis (PMF) and chronic granulocytic leukaemia (CGL) in megakaryoblastic transformation (CGL-Mk) gives rise to large numbers of progenitor cells committed to the megakaryocyte (Mk) lineage. As assessed by indirect immunof...

journal_title：Leukemia research

authors： Hibbin JA,Matutes E,Goldman JM

更新日期：1985-01-01 00:00:00

abstract：:The aim of this study was to evaluate effect of c-KIT mutations on RUNX1/RUNX1T1 fusion transcript expression in patients with t(8;21)-positive AML. Fifty patients diagnosed with t(8;21)-positive AML for recent 10 years were enrolled. Patients with c-KIT mutations tended to achieve a greater than 3-log reduction in RU...

journal_title：Leukemia research

authors： Park SH,Chi HS,Cho YU,Jang S,Park CJ

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND/AIMS:Jumping translocations are rare cytogenetic aberrations in haematological malignancies, the pathogenesis of which remains to be fully characterised. We investigated the mechanism of formation of jumping translocations in a case of adult common acute lymphoblastic leukaemia (ALL) positive for the Ph tran...

journal_title：Leukemia research

authors： Wan TS,Ma SK,Chow EY,Li YH,Lin SY,Chan LC

更新日期：2004-10-01 00:00:00

abstract：:We investigated the possible influence of recombinant (r) sIL-6R on the growth of three IL-6 non-responsive or weakly IL-6 responsive long-term myeloma cell lines. The three cell lines chosen for the study (U266, L363 and Fravel) all expressed gp130 but differed in their expression of IL-6R and IL-6. mRNA analysis by ...

journal_title：Leukemia research

authors： Diamant M,Hansen MB,Rieneck K,Svenson M,Yasukawa K,Bendtzen K

更新日期：1996-04-01 00:00:00

abstract：:A permanent lymphoblastoid cell line was established from the peripheral blood of a child with acute lymphoblastic leukemia. The cell line, designated SDK, grows in a stationary suspension culture, forming aggregates, in RPMI medium supplemented with 10% FCS, with a doubling time of 50-60 h. Immunologic markers and cy...

journal_title：Leukemia research

authors： Kottaridis S,Perez S,Kokkinopoulos D,Delinassios JG,Pangalis GA,Cosmidis H,Goula I,Papamichail M

更新日期：1985-01-01 00:00:00

abstract：:Allogeneic stem cell transplantation is considered to be a curative treatment modality in patients with chronic myelogenous leukemia. However patients are at risk for relapse years after transplantation. Currently we present two patients who relapsed 16 and 24 years after allogeneic bone marrow transplantation, respec...

journal_title：Leukemia research

authors： Sekhri A,Liu D,Rasul M,Ahmed N,Ahmed T,Seiter K

更新日期：2009-09-01 00:00:00

abstract：:Two AML patients, whose leukemic clonogenic cells totally reacted to the anti-lactofucopentaose III S4-7 monoclonal antibody (MoAb), underwent autologous bone marrow transplantation, in first complete remission, after in-vitro purging with S4-7 MoAb and complement. After ablative chemotherapy (BAVC regimen) and reinfu...

journal_title：Leukemia research

authors： Ferrero D,De Fabritiis P,Amadori S,De Felice L,Gallo E,Meloni G,Pregno P,Pulsoni A,Simone F,Tarella C

更新日期：1987-01-01 00:00:00

abstract：:The ability of A-MuLV to transform bone marrow cells on in vitro culture in agarose is enhanced by inclusion of conditioned media during infection and culture. The conditioned medium of a non-virus producing A-MuLV transformed fibroblast cell line was synergistic with medium from Whitlock-Witte long-term bone marrow c...

journal_title：Leukemia research

authors： Palumbo GJ,Ozanne B,Kettman JR

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The study aims to develop a prognostic scoring system based on prognostic lncRNAs for acute myeloid leukemia (AML). METHODS:Based on lncRNA expression profiles downloaded from The Cancer Genome Atlas (TCGA), differentially expressed long noncoding RNAs (DELs) between good prognosis and bad prognosis samples we...

journal_title：Leukemia research

authors： Zeng H,Wu H,Yan M,Tang L,Guo X,Zhao X

更新日期：2020-01-01 00:00:00

abstract：:It has become routine practice to culture bone marrow and/or unstimulated peripheral blood for cytogenetic analysis due to associations of consistent chromosomal abnormalities within specific subgroups of leukemias. Unfortunately, two leukemias for which numerous chromosomal aberrations have been recorded, acute myelo...

journal_title：Leukemia research

authors： Macera MJ,Szabo P,Verma RS

更新日期：1989-01-01 00:00:00