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Decreased microRNA-30a levels are associated with enhanced ABL1 and BCR-ABL1 expression in chronic myeloid leukemia.

Abstract：

:Chronic myeloid leukemia (CML) is associated with overexpression of BCR-ABL1, a nonreceptor tyrosine kinase critical for malignant transformation. We investigated whether non-coding microRNAs (miRNAs) targeting BCR-ABL1 mRNA contribute to the pathogenesis of CML. Indeed, miR-30a targeted BCR-ABL1 and was underexpressed in bone marrow from CML patients. In K562 leukemia cells, overexpression of miR-30a reduced ABL1 and BCR-ABL1 protein expression, decreased proliferation, and arrested cell cycle progression between G1 and S. These findings strongly suggest that miR-30a acts as a tumor suppressor by downregulating ABL1 and BCR-ABL1 expression. Upregulation of miR-30a in hematopoietic cells may have therapeutic efficacy against CML.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Liu Y,Song Y,Ma W,Zheng W,Yin H

doi

10.1016/j.leukres.2012.12.003

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

349-56

issue

3

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(12)00474-2

journal_volume

37

pub_type

杂志文章

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