Abstract:
:Our previous studies have demonstrated that a previously unrecognized role of CFTR in hematopoiesis and acute leukemia. Here, we show that CFTR inhibitor CFTR-inh172 possesses ability to inhibit human T-cell acute lymphoblastic leukemia cells. In detail, CFTR-inh172 inhibited cell proliferation, promoted apoptosis and arrested the cell cycle in human T-cell acute lymphoblastic leukemia cell CCRF-CEM, JURKAT and MOLT-4. Furthermore, transcriptome analysis reveals that CFTR-inh172 induces significant alteration of gene expression related to apoptosis and proliferation. These findings demonstrate the potential of CFTR inhibitor CFTR-inh172 in human T-cell acute lymphoblastic leukemia treatment.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Liu M,Liao H,Chen Y,Lin Z,Liu Y,Zhang X,Chan HC,Sun Hdoi
10.1016/j.leukres.2019.106225subject
Has Abstractpub_date
2019-11-01 00:00:00pages
106225eissn
0145-2126issn
1873-5835pii
S0145-2126(19)30170-5journal_volume
86pub_type
杂志文章abstract::Up to 30% of patients with acute myeloid leukemia (AML) and abnormal cytogenetics have persistent cytogenetic abnormalities (pCytAbnl) at morphologic complete remission (mCR). We hypothesized that the prognostic significance of pCytAbnl in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) i...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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abstract::In this study, the expression and functional characterization of currents through the CFTR (cystic fibrosis transmembrane regulator) and ORCC (outwardly rectifying chloride channels) were determined in wild-type K562 chronic human leukemia cells (K562-WT) and in its resistant counterpart, the vincristine resistant cel...
journal_title:Leukemia research
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2003.12.001
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journal_title:Leukemia research
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doi:10.1016/s0145-2126(96)00062-8
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journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/0145-2126(83)90042-5
更新日期:1983-01-01 00:00:00
abstract::We investigated the role of Src family kinases (SFKs) in the regulation of STAT activation in myeloid leukemia cells. Two of 6 AML cell lines displayed constitutive STAT5 activation, whereas four cell lines had constitutive SFK activity. Treatment with the SFK inhibitors suppressed STAT5 activation and decreased viabi...
journal_title:Leukemia research
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doi:10.1016/j.leukres.2007.11.032
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journal_title:Leukemia research
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doi:10.1016/s0145-2126(03)00216-9
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journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/s0145-2126(00)00078-3
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90090-0
更新日期:1984-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2008.12.013
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journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2014.02.008
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abstract::Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells. Ongoing protein synthase does not seem to be required for the initial induction of IL-8 gene expression. However, the rate of transient induction kinetics was modulated by cyclohexim...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)00151-y
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.02.013
更新日期:2007-02-01 00:00:00
abstract::The aim of this study was to evaluate effect of c-KIT mutations on RUNX1/RUNX1T1 fusion transcript expression in patients with t(8;21)-positive AML. Fifty patients diagnosed with t(8;21)-positive AML for recent 10 years were enrolled. Patients with c-KIT mutations tended to achieve a greater than 3-log reduction in RU...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.02.010
更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00026-7
更新日期:2002-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(97)00011-8
更新日期:1997-10-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(00)00053-9
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.12.021
更新日期:2014-03-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.05.023
更新日期:2017-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.04.003
更新日期:2014-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2010.06.003
更新日期:2010-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/0145-2126(90)90002-q
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90107-8
更新日期:1983-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.leukres.2013.01.004
更新日期:2013-06-01 00:00:00
abstract::Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisti...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.05.020
更新日期:2007-04-01 00:00:00
abstract::The myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic malignancies characterized by ineffective hematopoiesis, progressive bone marrow (BM) failure, cytogenetic and molecular abnormalities, and variable risk of progression to acute myeloid leukemia (AML). The BM microenvironment in MDS plays ...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2015.06.017
更新日期:2015-10-01 00:00:00