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PD-1/PD-L1 expression in extra-medullary lesions of multiple myeloma.

Abstract：

:Multiple myeloma patients may develop extraosseous involvement in the course of the disease making prognosis very poor and new drugs clearly needed. The PD-1/PD-L1 axis has emerged as a master immune checkpoint in antitumor responses and recent studies investigated the role of PD-L1 in multiple myeloma cells; no data however are still available about PD-L1 expression in extramedullary localizations. We demonstrate PD-L1 expression in 4/12 cases of extraosseous myeloma suggesting that these lesions represent a specialized microenvironment. We found presence of PD-1+ infiltrating lymphocytes in all observed cases supporting the relevance of PD-1/PD-L1 checkpoint in extramedullary myeloma. We also investigated the correlation in PD1/PD-L1 staining between marrow staining and EMP lesions.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Crescenzi A,Annibali O,Bianchi A,Pagano A,Donati M,Grifoni A,Avvisati G

doi

10.1016/j.leukres.2016.09.008

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

98-101

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(16)30194-1

journal_volume

49

pub_type

杂志文章

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