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Leukemic blast and natural killer cell P-glycoprotein function and inhibition in a clinical trial of zosuquidar infusion in acute myeloid leukemia.

Abstract：

:A bioassay was developed to assess P-glycoprotein (P-gp) function of peripheral blood natural killer (NK) cells and AML blasts during zosuquidar infusion. Cells were incubated with the fluorescent dye DiOC(2)(3) in the presence and absence of zosuquidar, and dye accumulation measured by flow cytometry. The assay performance was assessed using NK cells and the P-gp-positive K562/R7 cell line, and then utilized to determine the function of P-gp and its inhibition by zosuquidar in AML blasts and NK cells from patients enrolled in a Phase I trial. The assay of zosuquidar-inhibitable accumulation of DiOC(2) is robust and reproducible.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Marcelletti JF,Multani PS,Lancet JE,Baer MR,Sikic BI

doi

10.1016/j.leukres.2008.09.020

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

769-74

issue

6

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(08)00427-X

journal_volume

33

pub_type

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