当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study.

Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study.

Abstract：

:We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 cases) and 84% of follicular lymphomas (36 of 43 cases). Eighty-seven percent of t(14;18)-positive cases and 57% of t(14;18)-negative cases expressed bcl-2. FISH assays detected twice as many t(14;18)-positive follicular lymphomas as PCR assays. Overall, study findings support the use of FISH assays to detect t(14;18) in archival tumor samples for epidemiologic studies of NHL subtypes.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Chang CM,Schroeder JC,Huang WY,Dunphy CH,Baric RS,Olshan AF,Dorsey KC,Dent GA,Cerhan JR,Lynch CF,Rothman N,Cantor KP,Blair A

doi

10.1016/j.leukres.2009.05.007

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

190-5

issue

2

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(09)00260-4

journal_volume

34

pub_type

杂志文章

相关文献

LEUKEMIA RESEARCH文献大全
  • Serum erythropoietin concentrations in patients with myelodysplastic syndromes.

    abstract：:Medullary dyserythropoiesis with reduced production of erythrocytes is an early and consistent feature of myelodysplastic syndromes (MDS). The mechanism underlying the disturbed red cell proliferation and maturation is presently unknown. In order to study the role of erythropoietic growth factors, we determined by rad...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(91)90025-o

    authors： Aul C,Arning M,Runde V,Schneider W

    更新日期：1991-01-01 00:00:00

  • Myelodysplastic syndrome with transformation to acute monocytic leukemia with FLT3-ITD mutation following orthotopic liver transplantation.

    abstract：:A rare case of a 46-year-old man who underwent myelodysplastic syndrome, acute monocytic leukemia with FLT3-ITD mutation and splenic disruption following orthotopic liver transplantation is reported. The study of this case may be helpful to understand both the pathogenesis of acute leukemia and new complication of liv...

    journal_title：Leukemia research

    pub_type： 信件

    doi：10.1016/j.leukres.2005.11.025

    authors： Zhang GS,Dai CW,Peng HL,Xu YX,Pei MF

    更新日期：2006-07-01 00:00:00

  • Low plasma stem cell factor levels correlate with in vitro leukemic growth in myelodysplastic syndromes.

    abstract：:We evaluated the effect of SCF on myeloid differentiation by correlating clonogenic potential (as CFU-GM), bone marrow (BM) plasma SCF levels and CD34/c-kit expression in 57 MDS samples. There was a significant correlation between low SCF levels and 'leukemic' in vitro growth, the number of clusters and the colony/clu...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(98)00175-1

    authors： Cortelezzi A,Cattaneo C,Cristiani S,Sarina B,Pomati M,Silvestris I,Ibatici A,Maiolo AT

    更新日期：1999-03-01 00:00:00

  • Continuous intravenous infusion of high dose recombinant interleukin 2 for advanced lymphomas--a phase II study.

    abstract：:The prognosis of patients with advanced refractory lymphoma remains poor. We have carried out a Phase II study of continuous high dose intravenous recombinant interleukin 2 alone without LAK cells in this group of patients. Eight patients have so far been treated, 4 with non-Hodgkins lymphoma and 4 with Hodgkins disea...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0145-2126(91)90053-v

    authors： Lim SH,Worman CP,Callaghan T,Jewell A,Smith MP,Goldstone AH

    更新日期：1991-01-01 00:00:00

  • Flow cytometric assessment of three different methods for the measurement of in vitro apoptosis.

    abstract：:Chlorambucil-induced apoptosis was assessed by three different flow cytometric methods in B-cell chronic lymphocytic leukaemia (B-CLL) cells cultured in vitro and the results were compared with those derived from the morphological assessment of the same samples. Spontaneous apoptosis was consistently observed in the c...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(98)00013-7

    authors： Pepper C,Thomas A,Tucker H,Hoy T,Bentley P

    更新日期：1998-05-01 00:00:00

  • A pilot study of allogeneic cellular therapy for patients with advanced hematologic malignancies.

    abstract：:Allogeneic hematopoietic stem cell transplantation provides curative therapy for some patients with advanced hematologic malignancies. Disease response after allogeneic transplant is, at least in part, mediated by donor immune cells. In this report we describe a cellular therapy using haploidentical peripheral blood s...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.leukres.2008.05.015

    authors： Medina DJ,Gharibo M,Savage P,Cohler A,Kuriyan M,Balsara B,Anand M,Schaar D,Krimmel T,Saggiomo K,Manago J,Talty L,Dudek L,Grospe S,Rubin A,Strair RK

    更新日期：2008-12-01 00:00:00

  • Survival in acute myeloblastic leukemia is not prolonged by remission maintenance or early reinduction chemotherapy. The Toronto Leukemia Study Group.

    abstract：:A role for post-induction chemotherapy for adult patients with acute myeloblastic leukemia in remission has not been established. We have studied 125 patients with acute myeloblastic leukemia in complete remission to determine the effect on survival of remission maintenance therapy and of early reinduction therapy giv...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0145-2126(88)90136-1

    authors：

    更新日期：1988-01-01 00:00:00

  • Temporary blast reduction after immunoglobulin administration for congenital cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement.

    abstract：:Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisti...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2006.05.020

    authors： Metzler M,Bruch J,Stachel D,Langer T,Borkhardt A,Harbott J,Rascher W,Holter W

    更新日期：2007-04-01 00:00:00

  • Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production.

    abstract：:Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration wit...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2006.11.018

    authors： Sancho P,Galeano E,Nieto E,Delgado MD,García-Pérez AI

    更新日期：2007-07-01 00:00:00

  • Malignant hematopoietic cell lines: in vitro models for the study of Waldenström's macroglobulinemia.

    abstract：:Model cell lines are essential tools for investigating the biology and therapeutics of cancer. Approximately 1500 human hematopoietic neoplastic cell lines have been described, covering most major disease entities. Waldenström's macroglobulinemia (WM) is a rare incurable hematological neoplasm from which only three ce...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.leukres.2008.04.016

    authors： Drexler HG,MacLeod RA

    更新日期：2008-11-01 00:00:00

  • Subcellular distribution and profiles of prosomes (proteasomes-MCP) during differentiation of human lymphoblastic cell line.

    abstract：:The human lymphoblastoid leukemic cell line (CCRF-CEM) was induced to differentiate with phorbol 12-myristate 13-acetate (PMA). During differentiation, assessed by monitoring the cluster of differentiation (CD) profile, the prosome (proteasomes, multi-catalytic proteinase) distribution and composition were studied by ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(97)00091-x

    authors： Baz A,Henry L,Chateau MT,Scherrer K,Bureau JP

    更新日期：1997-11-01 00:00:00

  • Clinicopathological features and prognostic factors of Japanese patients with "peripheral T-cell lymphoma, unspecified" diagnosed according to the WHO classification.

    abstract：:Clinicopathological features of 36 patients, male: 58.3%; median: 68 years, with "peripheral T-cell lymphoma, unspecified" diagnosed by the WHO criteria were reviewed. Majority (69.4%) had stage IV disease with frequent involvements into bone marrow, spleen, liver, and skin. According to the IPI, 72.2% were categorize...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2004.04.016

    authors： Kojima H,Hasegawa Y,Suzukawa K,Mukai HY,Kaneko S,Kobayashi T,Kamoshita M,Shinagawa A,Komeno T,Komatsu T,Mitsuhashi S,Kawachi Y,Yamashita Y,Mori N,Nagasawa T

    更新日期：2004-12-01 00:00:00

  • Effects of the combination of decitabine and homoharringtonine in SKM-1 and Kg-1a cells.

    abstract：:The methylation inhibitor decitabine (DAC) has great therapeutic value for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, DAC monotherapy is associated with relatively low rates of overall response and complete remission. Previous studies have shown promising results for combination treatmen...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2016.02.002

    authors： Geng S,Yao H,Weng J,Tong J,Huang X,Wu P,Deng C,Li M,Lu Z,Du X

    更新日期：2016-05-01 00:00:00

  • Incidence and prognostic relevance of CD34 expression in acute myeloblastic leukemia: analysis of 141 cases.

    abstract：:In 141 adult patients with diagnosis of acute myeloid leukemia the overall expression and intensity of expression of CD34 antigen on leukemic cells was investigated. Myeloid blasts were tested by applying direct immunofluorescence staining using anti-CD34 fluorescein monoclonal antibody in flow cytometry. CD34 antigen...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(97)00015-5

    authors： Raspadori D,Lauria F,Ventura MA,Rondelli D,Visani G,de Vivo A,Tura S

    更新日期：1997-07-01 00:00:00

  • The role of thiotepa in autologous bone marrow transplantation for acute leukemia.

    abstract：:Post-transplant leukemic relapse remains the major problem following autologous bone marrow transplantation (ABMT). One possible approach to reducing the relapse rate is to intensify pre-transplant conditioning. Thiotepa (TTP) is an alkylating agent that has been used mainly in breast and ovarian cancer with 20-50% re...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0145-2126(98)00102-7

    authors： Nagler A,Finlander R,Or R,Naparstek E,Varadi G,Slavin S

    更新日期：1998-11-01 00:00:00

  • Non-Hodgkin's lymphoma: case control epidemiological study in Yorkshire.

    abstract：:This paper reports the results of a case control study of non-Hodgkin's lymphoma in the Yorkshire Health Region. In all, 437 cases and 724 controls were interviewed. Risk factors associated with past skin conditions, family history of cancer and infectious mononucleosis, aspects of social life and contact with wood du...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(98)80012-x

    authors： Cartwright RA,McKinney PA,O'Brien C,Richards ID,Roberts B,Lauder I,Darwin CM,Bernard SM,Bird CC

    更新日期：1988-01-01 00:00:00

  • A leukemic plasmacytoid dendritic cell line, PMDC05, with the ability to secrete IFN-alpha by stimulation via Toll-like receptors and present antigens to naïve T cells.

    abstract：:We established a plasmacytoid dendritic cell (pDC) line (PMDC05) from leukemia cells of pDC leukemia. PMDC05 cells were positive for CD4, CD56, CD33, HLA-DR, CD123 (IL-3Ralpha) and CD86 in the absence of lineage markers. mRNA of TLR1, TLR2, TLR4, TLR7 and TLR9 was clearly expressed and among these TLRs, TLR7 was promi...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.03.047

    authors： Narita M,Watanabe N,Yamahira A,Hashimoto S,Tochiki N,Saitoh A,Kaji M,Nakamura T,Furukawa T,Toba K,Fuse I,Aizawa Y,Takahashi M

    更新日期：2009-09-01 00:00:00

  • Immunocytochemical investigation of normal and chronic lymphocytic leukaemia lymphocytes reveals unexpectedly frequent reactivity with some myelomonocytic associated antibodies.

    abstract：:Information about the expression of some myelomonocytic markers in lymphocytes of patients with B-CLL is scarce. We studied the CD13, CD14, CD11c and CD68 surface antigens in 42 controls and in 38 patients with B-CLL to detect their possible reactivity. Eighty-nine percent of B-CLL expressed very strongly the CD14 ant...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(92)90177-9

    authors： Woessner S,Florensa L,Besses C,Vilà RM,Gallés C,Palou L,Sabrafen JS

    更新日期：1992-01-01 00:00:00

  • Low lymphocyte-to-monocyte ratio predicts unfavorable prognosis in non-germinal center type diffuse large B-cell lymphoma.

    abstract：:The peripheral blood lymphocyte to monocyte ratio (LMR) at diagnosis has been used to predict survival in diffuse large B-cell lymphoma (DLBCL) patients, but its prognostic significance with respect to different cell-of-origin (COO) subtypes remains unknown. We retrospectively analyzed 168 de novo DLBCL patients in th...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2014.03.013

    authors： Wei X,Huang F,Wei Y,Jing H,Xie M,Hao X,Feng R

    更新日期：2014-06-01 00:00:00

  • Establishment and characterization of a subclone (U-937-AG) from a permanent human monocyte cell line.

    abstract：:The human cell line U-937 has many features suggestive of the monocyte. It may be stimulated in vitro to develop attributes of an activated macrophage with increased phagocytosis and enhanced Fc receptor expression. We describe the establishment of a subclone designated U-937 AG through the use of a mutagenic agent. T...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(84)90084-5

    authors： Peacock TE,Kay NE,Ascensao JL,Kaplan ME

    更新日期：1984-01-01 00:00:00

  • Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP.

    abstract：BACKGROUND:Little is known on racial differences in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this retrospective study is to compare characteristics, prognostic factors and outcomes of Asian and Western patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and pred...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.01.002

    authors： Castillo JJ,Sinclair N,Beltrán BE,Song MK,Ilic I,Leppa S,Nurmi H,Seki R,Uccella S,Li JM,Treaba DO,Stachurski D,Butera JN

    更新日期：2013-04-01 00:00:00

  • Constitutional trisomy 8 and myelodysplasia: report of a case and review of the literature.

    abstract：:A diagnosis of myelodysplastic syndrome was made in an 18-year-old patient with Warkany syndrome due to constitutional trisomy 8 mosaicism. The possible causal role of this particular chromosome constitution with respect to myelodysplasia and embryonal childhood tumors is discussed. ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00050-x

    authors： Zollino M,Genuardi M,Bajer J,Tornesello A,Mastrangelo S,Zampino G,Mastrangelo R,Neri G

    更新日期：1995-10-01 00:00:00

  • Coexistence of independent myelodysplastic and Philadelphia chromosome positive clones in a patient treated with hydroxyurea.

    abstract：:We report a patient with Philadelphia chromosome positive (Ph +ve) chronic myelogenous leukemia (CML), treated with hydroxyurea alone, who upon disease progression developed an additional Ph - ve clone containing chromosomal abnormalities typical of myelodysplastic syndrome (MDS). Retrospective analysis of a cryoprese...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(01)00140-0

    authors： Flamm MJ,Murty VV,Rao PH,Nichols GL

    更新日期：2002-04-01 00:00:00

  • Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization.

    abstract：:Dimethyl sulfoxide (DMSO) is a widely used prototypical chemical inducer of cell differentiation. In the present study, the effects of DMSO on susceptibility of human myeloid leukemia U937 cells towards ligation of distinct death receptors (DRs) were investigated. DMSO sensitized cells towards induction of apoptosis b...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.05.016

    authors： Vondrácek J,Soucek K,Sheard MA,Chramostová K,Andrysík Z,Hofmanová J,Kozubík A

    更新日期：2006-01-01 00:00:00

  • Phase II study of low-dose topotecan in myelodysplastic syndromes: a Hoosier Oncology Group (HOG) study.

    abstract：:Topotecan has demonstrable activity in high-risk MDS and CMMoL. However, the significant toxicity of topotecan administered at a dose of 2mg/m2 i.v. daily for 5 days as a continuous infusion limits its use in older patients. Therefore, we studied topotecan 1.5mg/m2 per day i.v. over 2 h for three consecutive days in 2...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0145-2126(03)00181-4

    authors： Vaena DA,Walker P,Pennington K,Stephens A,Stender MJ,Yiannoutsos CT,Young C,Stoner C,Cripe LD,Hoosier Oncology Group.

    更新日期：2004-01-01 00:00:00

  • Submicroscopic deletions in an acute myeloid leukemia case with a four-way t(8;11;16;21).

    abstract：:The t(8;21)(q22;q22) rearrangement is observed in about 15% of acute myelocitic leukemia (AML) cases, while variant t(8;21) translocations are detected in 6-10% of AML patients positive for the 5'RUNX1/3'CBFA2T1 fusion gene. We report a detailed molecular cytogenetic analysis of a four-way variant t(8;11;16;21)(q22;q1...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2004.12.018

    authors： Albano F,Specchia G,Anelli L,Liso A,Zagaria A,Santoro A,Mirto S,Liso V,Rocchi M

    更新日期：2005-07-01 00:00:00

  • Metabolism of chylomicron-like emulsions in patients with Hodgkin's and with non-Hodgkin's lymphoma.

    abstract：BACKGROUND:Chylomicrons carry in the bloodstream dietary fats absorbed the intestine for storage in the body tissues such as adipose and muscle. The two-step chylomicron metabolism consists in lipolysis by lipoprotein lipase on vessel walls and hepatic uptake of triglyceride-depleted remnants. Chylomicron metabolism is...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(02)00087-5

    authors： Gonçalves RP,Hungria VT,Chiattone CS,Pozzi DB,Maranhão RC

    更新日期：2003-02-01 00:00:00

  • A role for mitochondrial DNA in the pathogenesis of radiation-induced myelodysplasia and secondary leukemia.

    abstract：:The onset of acute myeloid leukemia following ionizing radiation or alkylating agent exposure is antedated months to years by the development of 'preleukemia', or secondary myelodysplastic syndrome (sMDS). Mitochondrial abnormalities induced by chloramphenicol and clonal deletions of mitochondrial DNA (mt DNA) in the ...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/0145-2126(93)90036-k

    authors： Hatfill SJ,La Cock CJ,Laubscher R,Downing TG,Kirby R

    更新日期：1993-11-01 00:00:00

  • Metachronous and synchronous presentation of acute myeloid leukemia and lung cancer.

    abstract：:Smoking is associated with both acute myeloid leukemia (AML) and lung cancer. We therefore searched our database for concomitant presentation of AML and lung cancer. Among 775 AML cases and 5225 lung cancer cases presenting to Roswell Park Cancer Institute between the years January 1992 and May 2008 we found 12 (1.5% ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2008.12.016

    authors： Varadarajan R,Ford L,Sait SN,Block AW,Barcos M,Wallace PK,Ramnath N,Wang ES,Wetzler M

    更新日期：2009-09-01 00:00:00

  • Fatal hyperleukocytic syndrome in a patient with chronic myelomonocytic leukemia.

    abstract：:A 53-year-old male patient was admitted to our hospital with painful splenomegaly. He was diagnosed as having chronic myelomonocytic leukemia (CMML) with leukocytosis, monocytosis, increased lysozyme concentrations in serum und urine, and lack of the Philadelphia chromosome. The clinical course of the disease was char...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(96)00117-8

    authors： Aul C,Gattermann N,Germing U,Südhoff T,Hollmig KA,Heyll A

    更新日期：1997-03-01 00:00:00