Abstract:
BACKGROUND:Little is known on racial differences in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this retrospective study is to compare characteristics, prognostic factors and outcomes of Asian and Western patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). METHODS:Patient-level data was collected from 8 centers. All patients were diagnosed with DLBCL and treated with R-CHOP. Patients were divided into Asian and Western, according to the country of report. Comparisons and univariate/multivariate survival analyses were performed. RESULTS:712 patients, 455 Asian and 257 Western patients were included. Westerners were more likely to present with elevated LDH (64% vs. 48%, p<0.01) and advanced stage (58% vs. 49%, p<0.01). After a median follow-up of 36 months, there was no difference in progression-free (PFS; p=0.33) or overall survival (OS; p=0.69). There were no PFS or OS differences between races when evaluating separately each age-adjusted International Prognostic Index category. In the multivariate analyses, performance status and stage were associated with PFS and OS in both races. CONCLUSIONS:There are no differences in prognostic factors, PFS and OS between Asian and Western patients with DLBCL treated with R-CHOP.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Castillo JJ,Sinclair N,Beltrán BE,Song MK,Ilic I,Leppa S,Nurmi H,Seki R,Uccella S,Li JM,Treaba DO,Stachurski D,Butera JNdoi
10.1016/j.leukres.2013.01.002subject
Has Abstractpub_date
2013-04-01 00:00:00pages
386-91issue
4eissn
0145-2126issn
1873-5835pii
S0145-2126(13)00006-4journal_volume
37pub_type
杂志文章abstract::We evaluated the cytotoxicity of dimethylsphingosine (DMS) against four human leukemia cell lines: two acute (HL60 and a multi-drug resistance MDR-positive derivative HL60-dox) and two blast crisis chronic myelogenous leukemias (JFP1, from a treatment refractory patient and K562), and against blasts isolated from 11 l...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00129-1
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.08.018
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abstract::Forty patients with high risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) preceded by MDS were treated with intensive induction and consolidation chemotherapy in a prospective multicenter pilot study. They were given two cycles of cytarabine 100 mg/m with 12-h intervals on days 1-7 and idarubicin 12...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章,多中心研究
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abstract::When exposed to the anthracycline doxorubicin, K562 cells undergo differentiation which is characterized by arrested cell division, an increased mean cell diameter, and the production of hemoglobin. The influence of expression of p28, a low-molecular weight stress protein, on the differentiation of K562 cells was exam...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(00)00095-3
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abstract::The glycosylation of beta-hexosaminidase was investigated in the transformed cell-line, CCRF/CEM, derived from a human acute lymphoblastic leukaemia, and comparisons were made with enzyme from normal human skin fibroblasts. A series of studies including neuraminidase sensitivity, lectin chromatography, Biogel P4 chrom...
journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.leukres.2006.10.014
更新日期:2007-04-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.07.025
更新日期:2007-05-01 00:00:00
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journal_title:Leukemia research
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pub_type: 临床试验,杂志文章
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journal_title:Leukemia research
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doi:10.1016/0145-2126(84)90110-3
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journal_title:Leukemia research
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更新日期:2013-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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pub_type: 杂志文章
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