Survival in acute myeloblastic leukemia is not prolonged by remission maintenance or early reinduction chemotherapy. The Toronto Leukemia Study Group.

Abstract:

:A role for post-induction chemotherapy for adult patients with acute myeloblastic leukemia in remission has not been established. We have studied 125 patients with acute myeloblastic leukemia in complete remission to determine the effect on survival of remission maintenance therapy and of early reinduction therapy given at the time of predicted imminent relapse. Following remission induction with 6-thioguanine, cytosine arabinoside and daunorubicin (TAD), all patients received consolidation therapy with these same three drugs. Forty-three patients were randomized to arm A, continuing chemotherapy; 40 patients were randomized to arm B, no further chemotherapy until morphological relapse; and 42 patients were randomized to arm C, no further chemotherapy until an increase in myeloblast associated antigens was detected in bone marrow by means of antimyeloblast heteroantisera. The median durations of complete remission, age adjusted, for the three groups are not significantly different: 15.7 months for group A, 16.2 months for group B and 14.1 months for group C. The age adjusted median survivals for the three groups are also not significantly different: 17.6 months for group A, 21.8 months for group B and 18.8 months for group C. Quality of life was determined to be superior for patients having no further maintenance therapy (arms B and C). We conclude that our patients receiving induction and consolidation therapy with TAD did not benefit from remission maintenance or early reinduction chemotherapy, and had an improved quality of life if no maintenance therapy was given.

journal_name

Leuk Res

journal_title

Leukemia research

authors

doi

10.1016/0145-2126(88)90136-1

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

195-200

issue

3

eissn

0145-2126

issn

1873-5835

journal_volume

12

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.1016/s0145-2126(99)00119-8

    authors: Sasai Y,Horiike S,Misawa S,Kaneko H,Kobayashi M,Fujii H,Kashima K,Taniwaki M

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    authors: Ghoshal Gupta S,Baumann H,Wetzler M

    更新日期:2008-07-01 00:00:00

  • SMYD2 is highly expressed in pediatric acute lymphoblastic leukemia and constitutes a bad prognostic factor.

    abstract::Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although several clinical characteristics can be associated with worse prognosis, more robust biological markers still remains uncovered. SMYD2, a member of SMYD protein family, regulates the activity of several proteins through methylation. I...

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    更新日期:2014-04-01 00:00:00

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  • 3q26/EVI1 rearrangement in myelodysplastic/myeloproliferative neoplasms: An early event associated with a poor prognosis.

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    更新日期:2018-02-01 00:00:00

  • Less apoptosis in patients with 5q-syndrome than in patients with refractory anemia.

    abstract::The WHO classification of hematological malignancies includes 5q-syndrome as a separate category within myelodysplastic syndromes (MDS). Clinically, patients with 5q-syndrome have a milder disease than patients with other MDS. The basis for this difference is not known. Identifying 5q-syndrome can be difficult because...

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    更新日期:2002-10-01 00:00:00

  • Difference in effects of interferon-alpha and interferon-gamma on the induction of differentiation of retinoic acid-treated acute myeloid leukemia cells in primary culture.

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    doi:10.1016/0145-2126(90)90072-h

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    更新日期:1990-01-01 00:00:00

  • Balance of NF-kappaB and p38 MAPK is a determinant of radiosensitivity of the AML-2 and its doxorubicin-resistant cell lines.

    abstract::This study investigated radioresistance mechanisms in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100. AML-2/DX100 also showed resistance to radiation. AML-2/DX100 characterized by down-regulated catalase expression was supersensitive to exogenous hydrogen peroxide whereas they increased defense mec...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/j.leukres.2006.11.006

    authors: Choi CH,Xu H,Bark H,Lee TB,Yun J,Kang SI,Oh YK

    更新日期:2007-09-01 00:00:00

  • Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/j.leukres.2005.07.015

    authors: Inomata M,Takahashi S,Harigae H,Kameoka J,Kaku M,Sasaki T

    更新日期:2006-06-01 00:00:00

  • Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/j.leukres.2012.03.018

    authors: Pullarkat V,Sehgal A,Li L,Meng Z,Lin A,Forman S,Bhatia R

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  • Myelodysplastic syndrome associated with Griscelli syndrome.

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    journal_title:Leukemia research

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    doi:10.1016/s0145-2126(98)00075-7

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    pub_type: 杂志文章,评审

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    doi:10.1016/0145-2126(92)90114-m

    authors: Marks DC,Belov L,Davey MW,Davey RA,Kidman AD

    更新日期:1992-12-01 00:00:00

  • Induction of cytidine deaminase in HL-60 myeloid leukemic cells by 5-aza-2'-deoxycytidine.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(90)90067-j

    authors: Momparler RL,Laliberté J

    更新日期:1990-01-01 00:00:00

  • Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/s0145-2126(00)00130-2

    authors: Hofmann WK,Miller CW,Tsukasaki K,Tavor S,Ikezoe T,Hoelzer D,Takeuchi S,Koeffler HP

    更新日期:2001-04-01 00:00:00

  • The Dana Farber consortium protocol (DFCP) vs. classic Hyper-CVAD for treatment of acute lymphoblastic leukemia in patients

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    journal_title:Leukemia research

    pub_type: 杂志文章

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  • Smoking as a contributing factor for development of polycythemia vera and related neoplasms.

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    journal_title:Leukemia research

    pub_type: 杂志文章,评审

    doi:10.1016/j.leukres.2015.09.002

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    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.leukres.2020.106367

    authors: Talati C,Goldberg AD,Przespolewski A,Chan O,Ali NA,Kim J,Famulare C,Sallman D,Padron E,Kuykendall A,Lancet JE,Wang E,Tallman MS,Komrokji R,Sweet K

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  • A role for mitochondrial DNA in the pathogenesis of radiation-induced myelodysplasia and secondary leukemia.

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    pub_type: 杂志文章,评审

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    authors: Hatfill SJ,La Cock CJ,Laubscher R,Downing TG,Kirby R

    更新日期:1993-11-01 00:00:00

  • From sideroblastic anemia to the role of mitochondrial DNA mutations in myelodysplastic syndromes.

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    journal_title:Leukemia research

    pub_type: 杂志文章,评审

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  • Aetiologic factors in lymphoid malignancies: a case-control epidemiological study.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(84)90016-x

    authors: Bernard SM,Cartwright RA,Bird CC,Richards ID,Lauder I,Roberts BE

    更新日期:1984-01-01 00:00:00

  • Constitutional trisomy 8 and myelodysplasia: report of a case and review of the literature.

    abstract::A diagnosis of myelodysplastic syndrome was made in an 18-year-old patient with Warkany syndrome due to constitutional trisomy 8 mosaicism. The possible causal role of this particular chromosome constitution with respect to myelodysplasia and embryonal childhood tumors is discussed. ...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(95)00050-x

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    更新日期:1995-10-01 00:00:00

  • Prototypical HTLV-I/II infection is rare in LGL leukemia.

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    journal_title:Leukemia research

    pub_type: 杂志文章

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    更新日期:1994-06-01 00:00:00

  • Candidate gene mutation analysis in idiopathic acquired sideroblastic anemia (refractory anemia with ringed sideroblasts).

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  • A phase I and pharmacodynamic study of sequential topotecan and etoposide in patients with relapsed or refractory acute myelogenous and lymphoblastic leukemia.

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    journal_title:Leukemia research

    pub_type: 临床试验,杂志文章

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  • Clinical features of MDS.

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

    doi:10.1016/j.leukres.2008.11.023

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    更新日期:2009-05-01 00:00:00

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(86)90235-3

    authors: Brown G,Bunce CM,Johnson GD,Lord JM

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  • S-phase DNA content and aneuploidy of immunophenotypic defined subpopulations in acute myeloid leukemia determined by multi-parameter flow cytometry.

    abstract::One of the major limitations of DNA flow cytometry (FCM) in hematologic malignancies is the lack of information about the proliferation activity of subpopulations of the heterogeneous bone marrow (BM) compartment. We studied the S-phase DNA content of immunophenotypically defined BM subpopulations (CD2+; CD19+; CD2/CD...

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    pub_type: 杂志文章

    doi:10.1016/0145-2126(91)90467-8

    authors: Brons P,Pennings A,Haanen C,Wessels H,Boezeman J

    更新日期:1991-01-01 00:00:00