当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > A leukemic plasmacytoid dendritic cell line, PMDC05, with the ability to secrete IFN-alpha by stimulation via Toll-like receptors and present antigens to naïve T cells.

A leukemic plasmacytoid dendritic cell line, PMDC05, with the ability to secrete IFN-alpha by stimulation via Toll-like receptors and present antigens to naïve T cells.

Abstract：

:We established a plasmacytoid dendritic cell (pDC) line (PMDC05) from leukemia cells of pDC leukemia. PMDC05 cells were positive for CD4, CD56, CD33, HLA-DR, CD123 (IL-3Ralpha) and CD86 in the absence of lineage markers. mRNA of TLR1, TLR2, TLR4, TLR7 and TLR9 was clearly expressed and among these TLRs, TLR7 was prominent. Production of IFN-alpha and IL-12 in PMDC05 was enhanced by the stimulation with CpG-A and LPS, respectively. PMDC05 possessed a considerable antigen presenting ability, which was enhanced by culturing with IL3, influenza virus or LPS. PMDC05 could be a useful tool for investigating the pathophysiology of pDCL.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Narita M,Watanabe N,Yamahira A,Hashimoto S,Tochiki N,Saitoh A,Kaji M,Nakamura T,Furukawa T,Toba K,Fuse I,Aizawa Y,Takahashi M

doi

10.1016/j.leukres.2009.03.047

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

1224-32

issue

9

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(09)00161-1

journal_volume

33

pub_type

杂志文章

相关文献

LEUKEMIA RESEARCH文献大全
  • Dephosphorylation of specific proteins in HL-60 cells by 1 alpha, 25-dihydroxyvitamin D3: possible involvement of cAMP-dependent protein kinase.

    abstract：:Changes of phosphoprotein patterns in HL-60 cells were studied during short exposures to 1 alpha, 25-dihydroxyvitamin D3 [1,25(OH)2D3]. One hundred nanometers 1,25(OH)2D3 dephosphorylated at least three proteins in 6 h: phosphoproteins with molecular weights of 82 kD (pp82), 33 kD (pp33), and 31 kD (pp31). Phosphoryla...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(91)90169-t

    authors： Ueda T,Sawada H,Okuda T,Yumoto Y,Kato Y,Ogawa K,Tashima M,Yoshida Y,Okuma M

    更新日期：1991-01-01 00:00:00

  • FcRIII (CD16) expression on neutrophils from chronic myeloid leukemia. A flow cytometric study.

    abstract：:FcRIII (CD16) expression on neutrophils from 17 patients with chronic myeloid leukemia (CML) was studied by flow cytometry using monoclonal antibodies. A variable proportion of CD16-negative neutrophils were found both in CML patients in chronic phase (3 out of 8 patients) and in CML patients in hematological remissio...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(92)90120-v

    authors： Carulli G,Gianfaldoni ML,Azzara A,Papineschi F,Vanacore R,Minnucci S,Testi R,Ambrogi F

    更新日期：1992-12-01 00:00:00

  • Angiogenic activity of classical hematopoietic cytokines.

    abstract：:Hematopoiesis is regulated by several cytokines with pleiotropic activity. Several evidences have clearly demonstrated that these molecules, formerly regarded as specific for the hematopoietic system, also affect certain endothelial cell functions and that hematopoietic factors clearly influence angiogenesis. This rev...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.leukres.2012.02.003

    authors： Ribatti D

    更新日期：2012-05-01 00:00:00

  • The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML).

    abstract：:We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (≥ 4 versus ≤ 1) wa...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2014.06.018

    authors： Elliot K,Tooze JA,Geller R,Powell BL,Pardee TS,Ritchie E,Kennedy L,Callahan KE,Klepin HD

    更新日期：2014-10-01 00:00:00

  • Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias.

    abstract：:Over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), playing a role in leukemogenesis while decreased expression of PU.1 induces AML in mice model. Therefore, we speculated that there is an inverse relationship between these two factors. To clarify this, we measured the expression level of Fl...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.07.015

    authors： Inomata M,Takahashi S,Harigae H,Kameoka J,Kaku M,Sasaki T

    更新日期：2006-06-01 00:00:00

  • The anti-angiogenesis agent, AG-013736, has minimal activity in elderly patients with poor prognosis acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

    abstract：:AG-013736 is an oral anti-angiogenesis agent with activity against a variety of receptor tyrosine kinases, including VEGFR-1, VEGFR-2, VEGFR-3, c-kit, and PDGFR-beta. A phase 2 study was conducted in patients with poor prognosis AML or MDS. Twelve patients (six AML; six MDS) were treated with AG-013736 at a dose of 10...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.10.024

    authors： Giles FJ,Bellamy WT,Estrov Z,O'Brien SM,Verstovsek S,Ravandi F,Beran M,Bycott P,Pithavala Y,Steinfeldt H,Reich SD,List AF,Yee KW

    更新日期：2006-07-01 00:00:00

  • FISH analysis in addition to G-band karyotyping: utility in evaluation of myelodysplastic syndromes?

    abstract：:Cytogenetic analysis provides important diagnostic and prognostic information for patients with myelodysplastic syndromes (MDS). Prior studies, mostly comprised of small sample sizes, have reported conflicting results while evaluating the usefulness of FISH in addition to G-band karyotyping in MDS. In the current stud...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.09.013

    authors： Yang W,Stotler B,Sevilla DW,Emmons FN,Murty VV,Alobeid B,Bhagat G

    更新日期：2010-04-01 00:00:00

  • c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D.

    abstract：:1,25-Dihydroxyvitamin D3 (1,25D) induces differentiation of myeloid leukemia cells, but resistant cells are also encountered. We studied the mechanistic basis for the resistance in a model system using enhancers of 1,25D, the antioxidant carnosic acid and a kinase inhibitor SB202190. Knock-down (KD) of JNK2p54 unexpec...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.03.003

    authors： Chen-Deutsch X,Garay E,Zhang J,Harrison JS,Studzinski GP

    更新日期：2009-10-01 00:00:00

  • Biochemical and immunological characteristics of ferritin from HL-60, U-937 and K-562 cell lines: implications for haemopoietic regulation.

    abstract：:It has been suggested that acidic isoferritins play a major role in the regulation of human granulocyte-macrophage (CFU-GM) proliferation. Such regulatory isoferritins are said to occur in some human tissues including both leukaemic and normal leucocytes, and certain established cell lines. They are glycosylated and b...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(84)90065-1

    authors： Wyllie F,Jacobs A,Waradanukul K,Worwood M,Wagstaff M

    更新日期：1984-01-01 00:00:00

  • A coordinated proto-oncogene expression characterizes MCF 247 murine leukemia virus-induced T-cell lymphomas irrespectively of proviral insertion affecting myc loci.

    abstract：:Proto-oncogene transcriptional activation was analyzed in a group of MCF 247 MuLv-induced T-cell lymphomas to identify transformation-specific gene activations and determine whether the proviral insertion near a myc gene could promote a peculiar mechanism of transformation through a differential proto-oncogene express...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(90)90007-v

    authors： Boiocchi M,Dolcetti R,Maestro R,Feriotto G,Rizzo S,De Re V,Sonego F

    更新日期：1990-01-01 00:00:00

  • CD105 and placental growth factor--potent prognostic factors in childhood acute lymphoblastic leukaemia.

    abstract：:The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Research protocol was based on detection of RNA and protein expressions in bone marrow blasts using quantitative PCR and immunocytoche...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.03.017

    authors： Sujka-Kordowska P,Malinska A,Ostalska-Nowicka D,Zabel M,Nowicki M

    更新日期：2012-07-01 00:00:00

  • Adult T-cell leukemia: a report on two white patients.

    abstract：:Two white European males are reported with adult T-cell leukemia (ATL), a disease first described in Japan, but recently also in the U.K. and U.S.A. Both patients presented with lymphadenopathy, but without a mediastinal mass. In addition, one patient had skin infiltrates and the other had hepatosplenomegaly. Morpholo...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(83)90055-3

    authors： Tricot GJ,Broeckaert-Van Orshoven A,den Ottolander GJ,de Wolf-Peeters C,Meyer CJ,Verwilghen RL,Jansen J

    更新日期：1983-01-01 00:00:00

  • Mouse monoclonal antibodies direct phagocytosis of tumor cells by human monocytes.

    abstract：:Human peripheral blood monocytes were found to be capable of phagocytizing human B-non Hodgkin's lymphoma (NHL) cells coated with mouse monoclonal antibodies (MoAbs). The MoAbs used recognized idiotypic determinants on the surface immunoglobulin (Ig) of the tumor cells. MoAbs of IgG1 and IgG2a subclass were equally ef...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(86)90344-9

    authors： Calafat J,Janssen H,Hekman A

    更新日期：1986-01-01 00:00:00

  • Levels of CAF7 (CD98) expression correlate with the complete remission duration in childhood acute leukemia.

    abstract：:The levels of expression of the activation antigen CD98 were studied by mAB CAF7 in 51 newly diagnosed consecutive cases of childhood acute lymphoblastic leukemia aged from 1 to 13 years. The mean follow-up was 8 months. A wide range of CAF7 expression was observed, the highest mean fluorescence intensity exceeding th...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00114-x

    authors： Taskov H,Pashov A,ffmitrova E,Yordanova M,Serbinova M

    更新日期：1996-01-01 00:00:00

  • Combination of all-trans retinoic acid and lithium chloride surmounts a retinoid differentiation block induced by expression of Scl and Rbtn2 transcription factors in myeloid leukemia cells.

    abstract：:We have previously shown that forced expression of the transcription factor Scl in WEHI-3B D(+) cells prevents ATRA-induced cell differentiation. We now find that the overexpression of Rbtn2 also interferes with induction of differentiation by ATRA. Addition of LiCl to ATRA treatment restored the capacity of both Scl-...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2003.08.011

    authors： Rice AM,Li J,Sartorelli AC

    更新日期：2004-04-01 00:00:00

  • Variations in incidence of childhood leukaemia in South East Scotland (1970-1984).

    abstract：:Concern has been expressed recently about apparent increases in the incidence of leukaemia amongst young people living in certain geographical areas. We analysed the incidence of childhood leukaemia in South-East Scotland (excluding North-East Fife) from 1970 to 1984. There was a significant geographical variation in ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(86)90091-3

    authors： Gerrard M,Eden OB,Stiller CA

    更新日期：1986-01-01 00:00:00

  • The reproducibility of acute lymphoblastic leukemia phenotype determinations: evaluation of monoclonal antibody and conventional hematopoietic markers.

    abstract：:Peripheral blood and/or bone marrow lymphoblasts from 25 patients with acute lymphoblastic leukemia (ALL) were tested with a panel of monoclonal antibodies (MoAbs) and conventional hematopoietic markers by three different laboratories. The results were analysed to evaluate the reproducibility of ALL phenotype determin...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(86)90083-4

    authors： Sobol RE,Mick R,LeBien TW,Ozer H,Minowada J,Anderson K,Ellison RR,Cuttner J,Morrison A,Richards F 2nd

    更新日期：1986-01-01 00:00:00

  • Allogeneic marrow transplantation for acute leukemia in relapse.

    abstract：:The results of allogeneic marrow transplantation in 75 patients with acute lymphoblastic leukemia and 63 patients with acute non-lymphoblastic leukemia in relapse are reviewed. The effects of various chemotherapeutic regimens added to the basic regimen of cyclophosphamide (Cy) 60 mg/kg given on each of two successive ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(82)90101-1

    authors： Badger C,Buckner CD,Thomas ED,Clift RA,Sanders JE,Stewart PS,Storb R,Sullivan KM,Shulman H,Flournoy N

    更新日期：1982-01-01 00:00:00

  • Imatinib-resistant K562 cells are more sensitive to celecoxib, a selective COX-2 inhibitor: role of COX-2 and MDR-1.

    abstract：:Selective inhibition of the BCR/ABL tyrosine kinase by imatinib (STI571, Glivec/Gleevec) is the therapeutic strategy in patients with chronic myelogenous leukemia (CML). Despite significant hematologic and cytogenetic responses with imatinib, mainly due to the mutations in the Abl kinase domain, resistance occurs in p...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2007.11.007

    authors： Arunasree KM,Roy KR,Anilkumar K,Aparna A,Reddy GV,Reddanna P

    更新日期：2008-06-01 00:00:00

  • Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial.

    abstract：:A national cooperative group trial was conducted in 153 patients with chronic myelogenous leukemia (CML) in chronic phase treated with oral pulse busulfan to determine if oral vitamin A can increase the time to blast crisis and enhance survival of patients. Patients diagnosed within 1 year and in the chronic phase of ...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/0145-2126(95)00032-j

    authors： Meyskens FL Jr,Kopecky KJ,Appelbaum FR,Balcerzak SP,Samlowski W,Hynes H

    更新日期：1995-09-01 00:00:00

  • The role of platelet-derived growth factor on human pluripotent progenitor (CFU-GEMM) growth in vitro.

    abstract：:The effect of serum on the proliferation of human bone marrow pluripotent progenitor cells (CFU-GEMM), was compared to that of fresh frozen plasma (FFP). Serum significantly increased the number of mixed erythroid-granulocytic-megakaryocytic colonies (CFU-GEMM) and erythrocytic bursts (BFU-E) in this assay system (p l...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(85)90062-1

    authors： Michalevicz R,Francis GE,Price GM,Hoffbrand AV

    更新日期：1985-01-01 00:00:00

  • Combination of erythropoietin and thalidomide for the treatment of anemia in patients with myelodysplastic syndromes.

    abstract：:We investigated the therapeutic activity of recombinant erythropoietin (r-EPO) in association with thalidomide in 30 patients with myelodysplastic syndromes (MDS), previously treated with r-EPO (n.15, group A) or thalidomide (n.15, group B) as single agents, respectively, without any significant benefit on their anemi...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.08.020

    authors： Musto P,Falcone A,Sanpaolo G,Bodenizza C

    更新日期：2006-04-01 00:00:00

  • Good riddance to the term "refractory anemia" in myelodysplastic syndromes.

    abstract：:The term "refractory anemia" was used in 1937 by Cornelius Parker Rhoads to describe patients whose anemia did not improve after treatment with liver extract or iron salts, and this term has been used to denote patients with certain subtypes of myelodysplastic syndromes (MDS) since the 1976 and 1982 French-American-Br...

    journal_title：Leukemia research

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.leukres.2016.10.007

    authors： Steensma DP

    更新日期：2016-12-01 00:00:00

  • Pluripoietin effects on CFU-S lineage determination: possible mechanisms.

    abstract：:Regulation of pluripotent stem cell (CFU-S) proliferation kinetics by humoral factors is now well documented. However, the mechanism of choice of CFU-S differentiation pathways is still a controversial issue. We suggest that long-range humoral factors (pluripoietins) are capable of preferentially channelling CFU-S tow...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(84)90041-9

    authors： Frindel E,Vendrely C

    更新日期：1984-01-01 00:00:00

  • Synergy of FLT3 inhibitors and the small molecule inhibitor of LIM kinase1/2 CEL_Amide in FLT3-ITD mutated Acute Myeloblastic Leukemia (AML) cells.

    abstract：:Patients with FLT3-ITD mutated (FLT3-ITD+) Acute Myeloid Leukemia (AML), have frequently relapsed or refractory disease and FLT3-ITD+ inhibitors have limited efficacy. Rho kinases (ROCK) are constitutively activated by FLT3-ITD+ in AML via PI3 kinase and Rho GTPase. Upon activation by ROCK, LIM kinases (LIMK) inactiva...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2020.106490

    authors： Djamai H,Berrou J,Dupont M,Kaci A,Ehlert JE,Weber H,Baruchel A,Paublant F,Prudent R,Gardin C,Dombret H,Braun T

    更新日期：2020-12-13 00:00:00

  • Isolation of a novel chronic lymphocytic leukemic (CLL) cell line and development of an in vivo mouse model of CLL.

    abstract：:Leukemic cell lines have become important tools for studies of disease providing a monoclonal cell population that can be extensively expanded in vitro while preserving leukemic cellular characteristics. However, studies of chronic lymphocytic leukemia (CLL) have been impeded in part by the lack of continuous human ce...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2015.10.008

    authors： Kellner J,Wierda W,Shpall E,Keating M,McNiece I

    更新日期：2016-01-01 00:00:00

  • Immunotherapy in adult acute leukemia.

    abstract：:The treatment of acute myeloid leukemia (AML) did not evolve profoundly in the last decades. Some improvement has been made for acute lymphoblastic leukemia (ALL). Emerging new treatment modalities, such as immunotherapy, are now beginning to be available for acute leukemia, mostly for patients suffering from ALL. Thi...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.leukres.2017.06.011

    authors： Blum S,Martins F,Lübbert M

    更新日期：2017-09-01 00:00:00

  • Comparison of in vitro and in vivo effects of vincristine and vindesine on leukemic cells from patients with chronic granulocytic leukemia in blast crisis.

    abstract：:We employed a liquid culture system to examine the in vitro effects of vincristine and vindesine on cellular incorporation of 35SO4 into leukemic cells obtained from 5 patients with chronic granulocytic leukemia in blast crisis. The per cent of 35SO4 into drug-treated as compared to saline-treated leukemic cells was c...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(84)90062-6

    authors： Theodorakis ME,Goldberg J

    更新日期：1984-01-01 00:00:00

  • Reciprocal alterations of GMP reductase and IMP dehydrogenase activities during differentiation in HL-60 leukemia cells.

    abstract：:The study was undertaken to elucidate the regulatory roles of GMP reductase (GMPR) and IMP dehydrogenase (IMPDH) on purine interconversion during differentiation. Treatment of HL-60 cells with retinoic acid (1 microM) induced granulocytic differentiation which was accompanied with a 2.4-fold increase in GMPR and 55% d...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(92)90002-o

    authors： Nakamura H,Natsumeda Y,Nagai M,Takahara J,Irino S,Weber G

    更新日期：1992-06-01 00:00:00

  • Serum levels of helper factors (IL-1 alpha, IL-1 beta and IL-6), T-cell products (sCD4 and sCD8), sIL-2R and beta 2-microglobulin in patients with B-CLL and benign B lymphocytosis.

    abstract：:Chronic B-lymphocytic leukemia (B-CLL) cells may be regulated by immune functions. In an attempt to analyze such functions, helper factors (IL-1 alpha, IL-1 beta and IL-6), T-cell products (sCD4 and sCD8) and sIL-2R and beta 2-microglobulin were measured in serum of patients at different stages of the disease. Patient...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(92)90009-v

    authors： Aguilar-Santelises M,Loftenius A,Ljungh C,Svenson SB,Andersson B,Mellstedt H,Jondal M

    更新日期：1992-06-01 00:00:00