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Assessment of proteasome concentration and chymotrypsin-like activity in plasma of patients with newly diagnosed multiple myeloma.

Abstract：

:The ubiquitin-proteasome pathway is implicated in the pathogenesis of many haematologic malignancies, including multiple myeloma. Under conditions of rapid cell turnover and growth rate, proteasomes are returned into circulation. The measurement of their levels or activity could offer a new approach to diagnosis, prognosis and monitoring of anticancer treatment in carcinoma patients. We analysed proteasome concentration and chymotrypsin-like (ChT-L) activity in the plasma of 64 patients with a newly diagnosed multiple myeloma and 30 healthy volunteers. The values were found to be significantly higher in the studied patients and advanced disease stages compared to the control group, and decreased significant after chemotherapy. Both proteasome concentration and ChT-L activity correlated with adverse prognostic factors, such as lactate dehydrogenase and β2-macroglobulin. We also showed that proteasome concentration positively correlates with IL-6 level, as opposed to proteasome ChT-L activity. Of note, higher proteasome ChT-L activity, unlike the concentration, was proved to be an indicator of a shorter progression free survival, constituting thereby an important prognostic marker.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Oldziej A,Bolkun L,Galar M,Kalita J,Ostrowska H,Romaniuk W,Kloczko J

doi

10.1016/j.leukres.2014.05.008

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

925-30

issue

8

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(14)00149-0

journal_volume

38

pub_type

杂志文章

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