Quality of life of patients with acute myeloid leukaemia.

abstract：:Based on Bcl-X(L) overexpression studies we identified type I and type II follicular lymphoma cell lines in response to TRAIL. We demonstrate here that either amount of caspase-8 activation or Bid cleavage could not define the dependence on mitochondria. Furthermore, an inhibitor of NF-kappaB, PDTC, enabled TRAIL to a...

journal_title：Leukemia research

authors： Nuutinen U,Simelius N,Ropponen A,Eeva J,Mättö M,Eray M,Pellinen R,Wahlfors J,Pelkonen J

更新日期：2009-06-01 00:00:00

abstract：:An acute promyelocytic leukemia in the rat (BNML) has been used in model studies on pathogenesis and therapy of human acute myeloid leukemia. The blood supply to bone marrow during BNML development has hitherto not been examined, even though in general, blood flow to hematopoietic tissues might affect drug treatment a...

journal_title：Leukemia research

authors： Iversen PO,Thing-Mortensen B,Nicolaysen G,Benestad HB

更新日期：1993-08-01 00:00:00

abstract：:N-Propyl-N-nitrosourea (PNU) was proved to be a strong leukemogen, which induces myelogenous leukemia or thymic lymphoma in rats. BUF/Mna rats and F344 rats were the strain most susceptible to thymic lymphomagenic activity of PNU. In addition, F1 rats between BUF/Mna and WKY rats were also susceptible to PNU-lymphomag...

journal_title：Leukemia research

authors： Ogiu T,Utsumi KR,Fukami H,Matsuyama M

更新日期：1988-01-01 00:00:00

abstract：:The aim of this study was to evaluate effect of c-KIT mutations on RUNX1/RUNX1T1 fusion transcript expression in patients with t(8;21)-positive AML. Fifty patients diagnosed with t(8;21)-positive AML for recent 10 years were enrolled. Patients with c-KIT mutations tended to achieve a greater than 3-log reduction in RU...

journal_title：Leukemia research

authors： Park SH,Chi HS,Cho YU,Jang S,Park CJ

更新日期：2013-07-01 00:00:00

abstract：:Hyaluronan (HA) modulates multidrug resistance (MDR) as well as cell migration. Tiam1 is involved in cytoskeleton reorganization during tumor invasion. In this report we show the relationship among HA, Tiam1, migration and MDR in murine lymphoma cell lines. We observed that MDR cells presented higher migratory capacit...

journal_title：Leukemia research

authors： Cordo-Russo RI,Alaniz LD,Saccodossi N,Lompardía S,Blanco G,Alvarez E,García MG,Hajos SE

更新日期：2010-11-01 00:00:00

abstract：:Exogenous expression of the transcription factor Scl (Tal1) in WEHI-3B D+ myelomonocytic leukemia cells interferes with their capacity to respond to all-trans retinoic acid (ATRA) induced differentiation; combination of ATRA with LiCl, however, circumvents the inhibition of differentiation produced by Scl. To gain inf...

journal_title：Leukemia research

authors： Rice AM,Holtz KM,Karp J,Rollins S,Sartorelli AC

更新日期：2004-11-01 00:00:00

abstract：:Introduction of the maturation index (MI) as a measure for the degree of maturation improved the subtyping of acute myeloid leukemia (AML). A comparison is made here between the MI and the results of surface marker analysis with a panel of monoclonal antibodies (McAb) in the immunofluorescence technique. The McAb appl...

journal_title：Leukemia research

authors： van Rhenen DJ,van der Reijden HJ,van't Veer MB,Engelfriet CP,von dem Borne AE,Langenhuijsen MM

更新日期：1983-01-01 00:00:00

abstract：:Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisti...

journal_title：Leukemia research

authors： Metzler M,Bruch J,Stachel D,Langer T,Borkhardt A,Harbott J,Rascher W,Holter W

更新日期：2007-04-01 00:00:00

abstract：:Heterogeneity for 5'nucleotidase has been demonstrated in chronic lymphocytic leukemia [12]. The enzyme is not detectable in the lymphocytes from the majority of patients with this disorder, but normal and even supranormal levels are found in some cases [17]. In the present studies, the properties of this ecto-nucleot...

journal_title：Leukemia research

authors： Conklyn MJ,Silber R

更新日期：1982-01-01 00:00:00

abstract：:The K562 leukemia cell line has been extensively used in studies of erythroid differentiation but it has been less well appreciated that treatment of K562 cells with the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) leads to loss of their erythroid properties and to acquisition of several megakaryoblastoi...

journal_title：Leukemia research

authors： Alitalo R

更新日期：1990-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is frequently treated with induction and consolidation chemotherapy. Consolidation chemotherapy can be delivered on an ambulatory basis, requiring some patients to travel long distances for treatment at specialized centers. We developed a shared care model where patients receive consolidat...

journal_title：Leukemia research

authors： Hershenfeld SA,Maki K,Rothfels L,Murray CS,Nixon S,Schimmer AD,Doherty MC

更新日期：2017-08-01 00:00:00

abstract：:Incorporation of ABL-targeted oral tyrosine kinase inhibitors (TKIs) into frontline therapeutic regimens has improved outcomes for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). However, patients with persistent minimal residual disease (MRD) exhibit increased risk of relapse. Co...

journal_title：Leukemia research

authors： King AC,Pappacena JJ,Tallman MS,Park JH,Geyer MB

更新日期：2019-04-01 00:00:00

abstract：:Pro-apoptotic signalling upon toll-like receptor (TLR) stimulation in myeloid cells is normally antagonized by the simultaneous activation of anti-apoptotic pathways. We have previously reported that IFN-alpha can sensitize human monocytes to apoptosis induction by lipopolysaccharide (LPS). Based on these results we i...

journal_title：Leukemia research

authors： Lehner M,Bailo M,Stachel D,Roesler W,Parolini O,Holter W

更新日期：2007-12-01 00:00:00

abstract：:Incidence and outcomes of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are not well established at the population level, especially since the widespread use of immunophenotyping. We studied the epidemiology of CLL in Manitoba (Canada) by combining data from a centralized flow cytometry facility and th...

journal_title：Leukemia research

authors： Seftel MD,Demers AA,Banerji V,Gibson SB,Morales C,Musto G,Pitz MW,Johnston JB

更新日期：2009-11-01 00:00:00

abstract：:Clofarabine (CLO), a purine nucleoside analog with promising efficacy in acute myeloid leukemia (AML), inhibits the ribonucleotidereductase, p53R2. We have shown that p53R2 mRNA is up-regulated by decitabine (DEC), another drug with promising activity in AML. We developed a pharmacodynamic model to characterize the in...

journal_title：Leukemia research

authors： Thudium KE,Ghoshal S,Fetterly GJ,Haese JP,Karpf AR,Wetzler M

更新日期：2012-11-01 00:00:00

abstract：:K-562 is described as a pluripotent leukemic cell line which expresses a diversity of hematopoietic cell differentiation antigens. With the use of monoclonal antibodies (MoAb), we show that the expression of these antigens is either "modulated", i.e. they are not expressed in early logarithmic growth but are expressed...

journal_title：Leukemia research

authors： Ichiki AT,Lozzio CB,Bamberger EG,Lucas PB,Wust CJ,Fuhr JE

更新日期：1987-01-01 00:00:00

abstract：:Gain-of-function mutations in the proto-oncogene c-kit that induce constitutive kinase activity of its product, KIT protein, are characteristic of human mast cell disease and are believed to play a central role in mast cell leukemia oncogenesis, proliferation and survival. Nuclear overexpression of the Wnt effector be...

journal_title：Leukemia research

authors： Kajiguchi T,Lee S,Lee MJ,Trepel JB,Neckers L

更新日期：2008-05-01 00:00:00

abstract：:In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MD...

journal_title：Leukemia research

authors： Yasunami T,Wang YH,Tsuji K,Takanashi M,Yamada Y,Motoji T

更新日期：2007-04-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is a widely used prototypical chemical inducer of cell differentiation. In the present study, the effects of DMSO on susceptibility of human myeloid leukemia U937 cells towards ligation of distinct death receptors (DRs) were investigated. DMSO sensitized cells towards induction of apoptosis b...

journal_title：Leukemia research

authors： Vondrácek J,Soucek K,Sheard MA,Chramostová K,Andrysík Z,Hofmanová J,Kozubík A

更新日期：2006-01-01 00:00:00

abstract：:We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic protein tyrosine kinase...

journal_title：Leukemia research

authors： Ghoshal Gupta S,Baumann H,Wetzler M

更新日期：2008-07-01 00:00:00

abstract：:Acute monocytic leukemia (M5) is a subtype of acute myeloid leukemia (AML) with two distinct morphologic subcategories, M5a and M5b. We compared the immunophenotype, cytogenetics and clinical outcome of AML M5 with non-M5 AML and also compared M5a with M5b. One hundred and twelve M5 (76 M5a, 36 M5b) and 726 non-M5 cas...

journal_title：Leukemia research

authors： Villeneuve P,Kim DT,Xu W,Brandwein J,Chang H

更新日期：2008-02-01 00:00:00

abstract：:Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-kappaB), which is a target molecule of these kin...

journal_title：Leukemia research

authors： Takahashi S,Harigae H,Ishii KK,Inomata M,Fujiwara T,Yokoyama H,Ishizawa K,Kameoka J,Licht JD,Sasaki T,Kaku M

更新日期：2005-08-01 00:00:00

abstract：:CD13/aminopeptidase-N, an enzyme expressed by myeloid cells, may be important in the regulation and signalling pathways that control myeloid growth and differentiation. In this study we have used the myeloid leukaemic cell line HL60, and its ability to differentiate when induced by all-trans-retinoic acid (ATRA), to s...

journal_title：Leukemia research

authors： Razak K,Allen PD,Kelsey SM,Gutteridge CN,Newland AC

更新日期：1994-08-01 00:00:00

abstract：:GNAS1 gene is located at the long arm of chromosome 20 (q13.32). GNAS1 gene deletion has never been investigated in MDS. A GNAS1 activating mutation (R201) was recently found in MDS. We applied FISH and DHPLC plus sequencing to investigate GNAS1 gene in MDS cases with and without del(20q) at karyotype. ...

journal_title：Leukemia research

authors： Di Giacomo D,Lema Fernandez AG,Pierini T,Crescenzi B,Brandimarte L,Matteucci C,Testoni N,Mecucci C

更新日期：2014-07-01 00:00:00

abstract：:The purpose of this study was to determine the sensitivity to merocyanine 540 (MC 540)-mediated photolysis of normal human hematopoietic progenitor cells and four leukemia cell lines (Daudi, Raji, K562 and HL-60). Late erythroid progenitors were the most sensitive normal cells. Early erythroid progenitors were of inte...

journal_title：Leukemia research

authors： Sieber F,Stuart RK,Rowley SD,Sharkis SJ,Sensenbrenner LL

更新日期：1987-01-01 00:00:00

abstract：:The surface marker phenotype of lymphocytes derived from 12 patients with B-CLL was compared to that of lymphocytes from 10 patients with an other monoclonal but clinical benign form of B-cell proliferative disorder termed monoclonal B-cell lymphocytosis of undetermined significance (B-MLUS). A panel of well character...

journal_title：Leukemia research

authors： Garcia C,Rosén A,Kimby E,Aguilar-Santelises M,Jondal M,Bjorkholm M,Holm G,Mellstedt H

更新日期：1989-01-01 00:00:00

abstract：:Useful prognostic markers for patients with diffuse large B cell lymphoma (DLBCL) have been reported. To identify which biomarker best predicts the prognosis of patients with DLBCL, we performed a retrospective study that included 319 DLBCL patients who had received rituximab, cyclophosphamide, doxorubicin, vincristin...

journal_title：Leukemia research

authors： Miyashita K,Tomita N,Taguri M,Suzuki T,Ishiyama Y,Ishii Y,Nakajima Y,Numata A,Hattori Y,Yamamoto W,Miyazaki T,Tachibana T,Takasaki H,Matsumoto K,Hashimoto C,Takemura S,Yamazaki E,Fujimaki K,Sakai R,Motomura S,Ishi

更新日期：2015-08-29 00:00:00

abstract：:Although biological and clinical features differ between B-lineage acute lymphoblastic leukemia (ALL) and T-lineage ALL (T-ALL), there have been few reports that focused on the prognosis for T-ALL in adults, primarily due to its rarity. Here, we studied the long-term outcomes and prognostic factors specific for adult ...

journal_title：Leukemia research

authors： Yanada M,Jinnai I,Takeuchi J,Ueda T,Miyawaki S,Tsuzuki M,Hatta Y,Usui N,Wada H,Morii T,Matsuda M,Kiyoi H,Okada M,Honda S,Miyazaki Y,Ohno R,Naoe T

更新日期：2007-07-01 00:00:00

abstract：:We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m(2) q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-r...

journal_title：Leukemia research

authors： Hassanein M,Atenafu EG,Schuh AC,Yee KW,Minden MD,Schimmer AD,Gupta V,Brandwein JM

更新日期：2013-05-01 00:00:00

abstract：:Some peripheral blood clonogenic T-cells from patients with T-cell malignancies can generate colonies in methylcellulose in the absence of added growth factors or mitogen stimulation (T-CFCs). T-CFC from these patients were also able to form colonies in semi-solid media in the presence of added growth factors (T-CFCi)...

journal_title：Leukemia research

authors： Georgoulias V,Auclair H,Jasmin C

更新日期：1984-01-01 00:00:00