Decreased blood flow to rat bone marrow, bone, spleen, and liver in acute leukemia.

abstract：:Leukemia-prone AKR mice were exposed twice a week to a 6 mT, 12 Hz or 460 Hz pulsed magnetic field for 30 min. If we take into account the five consecutive generations of mice, the above exposure actually took place in utero and, or during their life span. There was no difference in the incidence of leukemia or in the...

journal_title：Leukemia research

authors： Bellossi A

更新日期：1991-01-01 00:00:00

abstract：:Magnetic resonance provides a non-invasive tool for monitoring normal and leukemic bone marrow. Measurements of the T1 relaxation times are elevated in acute myelogenous leukemia. However, interpatient variability diminishes the usefulness of MR measurements for diagnosing leukemia. In following the time course of ind...

journal_title：Leukemia research

authors： Henkelman RM,Messner H,Poon PY,Hinks RS,Stewart C,Curtis J,Minden M,Baker M

更新日期：1988-01-01 00:00:00

abstract：:Replication of the Friend spleen focus forming virus (SFFV) in C3H/HeJ or C57BL/6J mouse continuous bone marrow cultures is associated with an increased cumulative production of pluripotential/hematopoietic stem cells (CFUs), granulocyte-macrophage progenitor cells (GM-CFUc), and total granulocytes, compared to uninfe...

journal_title：Leukemia research

authors： Greenberger JS,Eckner RJ,Sakakeeny MA,Cohen GI

更新日期：1983-01-01 00:00:00

abstract：:Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisti...

journal_title：Leukemia research

authors： Metzler M,Bruch J,Stachel D,Langer T,Borkhardt A,Harbott J,Rascher W,Holter W

更新日期：2007-04-01 00:00:00

abstract：:Resistance to chronic myeloid leukemia (CML) drug STI571 has been associated with point mutations in the kinase domain of BCR-ABL. For example, the mutation T315I (g. 68721C>T) and, to a lesser extent, Y253F (g. 58796A>T) appear in a significant proportion of patients resistant to treatment. Mutations appear intimatel...

journal_title：Leukemia research

authors： Liu WH,Makrigiorgos GM

更新日期：2003-11-01 00:00:00

abstract：:Peripheral neuropathy (PN), with neuropathic pain as main symptom, represents the dose-limiting toxicity of the proteasome inhibitor bortezomib. Aim of this study was to compare the incidence, risk factors, severity and outcome of PN and neuropathic pain in patient treated with bortezomib up-front or at relapse. We st...

journal_title：Leukemia research

authors： Corso A,Mangiacavalli S,Varettoni M,Pascutto C,Zappasodi P,Lazzarino M

更新日期：2010-04-01 00:00:00

abstract：:We retrospectively assessed morphologic and cytogenetic responses to 5-azacytidine and decitabine in a cohort of 42 adult therapy-related myelodysplastic syndromes (tMDS) patients treated at Memorial Sloan-Kettering Cancer Center and in 2 industry-sponsored decitabine trials (D0007 and DACO-020). The overall response ...

journal_title：Leukemia research

authors： Klimek VM,Dolezal EK,Tees MT,Devlin SM,Stein K,Romero A,Nimer SD

更新日期：2012-09-01 00:00:00

abstract：:To study the role of SDF-1/CXCR4 axis in MDS, the expression of SDF-1 and CXCR4, VEGF, MVD and apoptosis were measured in MDS. The results showed that the expression of SDF-1 of the low-grade MDS is higher than that of the high-grade MDS and the control. The high-grade MDS had a significantly higher CXCR4 expression o...

journal_title：Leukemia research

authors： Zhang Y,Zhao H,Zhao D,Sun L,Zhi Y,Wu X,Huang W,Da W

更新日期：2012-03-01 00:00:00

abstract：:The WHO classification of hematological malignancies includes 5q-syndrome as a separate category within myelodysplastic syndromes (MDS). Clinically, patients with 5q-syndrome have a milder disease than patients with other MDS. The basis for this difference is not known. Identifying 5q-syndrome can be difficult because...

journal_title：Leukemia research

authors： Washington LT,Jilani I,Estey E,Albitar M

更新日期：2002-10-01 00:00:00

abstract：:The onset of acute myeloid leukemia following ionizing radiation or alkylating agent exposure is antedated months to years by the development of 'preleukemia', or secondary myelodysplastic syndrome (sMDS). Mitochondrial abnormalities induced by chloramphenicol and clonal deletions of mitochondrial DNA (mt DNA) in the ...

journal_title：Leukemia research

authors： Hatfill SJ,La Cock CJ,Laubscher R,Downing TG,Kirby R

更新日期：1993-11-01 00:00:00

abstract：:We compared the efficacy and toxicity of BEAM (BCNU, etoposide, cytarabine and melphalan) and BuCyE (busulfan, cyclophosphamide and etoposide), given prior to autologous stem cell transplantation (ASCT), in 65 patients with non-Hodgkin's lymphoma. Of these 65 patients, 43 received BEAM and 22 received BuCyE. Their age...

journal_title：Leukemia research

authors： Kim JE,Lee DH,Yoo C,Kim S,Kim SW,Lee JS,Park CJ,Huh J,Suh C

更新日期：2011-02-01 00:00:00

abstract：:Mononuclear cells from a bone marrow infiltrated by plasmacytoma cells were examined by electron microscopy. An analysis was performed according to different cytoarchitectural forms of the endoplasmic reticulum (ER). Six types of plasma cells could be distinguished. The bone marrow cells were treated with an anti-idio...

journal_title：Leukemia research

authors： Renau-Piqueras J,Wetter O,Miragall F,Brandhorst D,Martinez-Ramon A

更新日期：1984-01-01 00:00:00

abstract：:Increasing evidence suggest that epigenetic mechanisms (e.g. histone modification by histone deacetylases) play a major role in the pathogenesis of Hodgkin's lymphoma (HL). We treated HL cell lines with the histone deacetylase inhibitor vorinostat and investigated the gene expression profile of these cells by using DN...

journal_title：Leukemia research

authors： Kewitz S,Bernig T,Staege MS

更新日期：2012-06-01 00:00:00

abstract：:Treatment failure of patients with acute myelogenous leukemia (AML) is frequently due to the development of multidrug resistance phenotype blasts. We have expressed a fusion protein consisting of human granulocyte-macrophage colony stimulating factor (GMCSF) fused to the N-terminus of a lectin-deficient ricin toxin B ...

journal_title：Leukemia research

authors： Burbage C,Tagge EP,Harris B,Hall P,Fu T,Willingham MC,Frankel AE

更新日期：1997-07-01 00:00:00

abstract：:We evaluated the effect of SCF on myeloid differentiation by correlating clonogenic potential (as CFU-GM), bone marrow (BM) plasma SCF levels and CD34/c-kit expression in 57 MDS samples. There was a significant correlation between low SCF levels and 'leukemic' in vitro growth, the number of clusters and the colony/clu...

journal_title：Leukemia research

authors： Cortelezzi A,Cattaneo C,Cristiani S,Sarina B,Pomati M,Silvestris I,Ibatici A,Maiolo AT

更新日期：1999-03-01 00:00:00

abstract：:We have previously shown that heparin and heparan sulfate stimulate the growth of human erythroleukemia cells in vitro in the presence of serum or plasma. To determine whether heparin and other glycosaminoglycans (GAGs) are involved in the growth of leukemia cells, effects of GAGs on the growth of three leukemia cell ...

journal_title：Leukemia research

authors： Maurer AM,Han ZC,Dhermy D,Brière J

更新日期：1994-11-01 00:00:00

abstract：:Murine erythroleukemia (MEL) cells undergo erythroid differentiation in vitro when treated with hexamethylene bisacetamide (HMBA). To identify genes involved in the commitment of MEL cells to differentiate, we screened a cDNA library constructed from HMBA-induced cells by differential hybridization and isolated GTPase...

journal_title：Leukemia research

authors： Vanegas N,García-Sacristán A,López-Fernández LA,Párraga M,del Mazo J,Hernández P,Schvartzman JB,Krimer DB

更新日期：2003-07-01 00:00:00

abstract：:We wish to demonstrate new evidence for the in vivo production of interleukin-3 (IL-3). Syngeneic murine splenocytes were transplanted into lethally irradiated mice. The spleen cells in these transplant mice spontaneously produced IL-3 in cultures, and IL-3-like activity was detected in the serum. Chronological change...

journal_title：Leukemia research

authors： Hirokawa M,Takatsu H,Chubachi A,Kudo K,Takahashi T,Yoshida K,Miura AB

更新日期：1989-01-01 00:00:00

abstract：:Incorporation of ABL-targeted oral tyrosine kinase inhibitors (TKIs) into frontline therapeutic regimens has improved outcomes for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). However, patients with persistent minimal residual disease (MRD) exhibit increased risk of relapse. Co...

journal_title：Leukemia research

authors： King AC,Pappacena JJ,Tallman MS,Park JH,Geyer MB

更新日期：2019-04-01 00:00:00

abstract：:We report on the clinico-biological characteristics of 20 cases of gammadelta T cell large granular lymphocyte (LGL) leukemia. All the data were compared to that of 196 cases with alphabeta T cell subtype, which represents the majority of T cell LGL leukemias. Clinical findings were quite similar in the two groups reg...

journal_title：Leukemia research

authors： Bourgault-Rouxel AS,Loughran TP Jr,Zambello R,Epling-Burnette PK,Semenzato G,Donadieu J,Amiot L,Fest T,Lamy T

更新日期：2008-01-01 00:00:00

abstract：:MEK/ERK signal pathway was required for the differentiation of granulocytes, megakaryocytes and erythrocytes. Recently, MEK/ERK cascade was reported to be involved in all-trans retinoic acid (ATRA) induced differentiation in acute promyelocytic leukemia (APL) cells. However, the upstream and downstream molecules of ME...

journal_title：Leukemia research

authors： Weng XQ,Sheng Y,Ge DZ,Wu J,Shi L,Cai X

更新日期：2016-06-01 00:00:00

abstract：:The genes for the CDK4/6-inhibitors p16INK4A/MTS1 and p15INK4B/MTS2 are frequently deleted in hematological malignancies. A new member of this family of CDK4/6 inhibitors is p18. In order to assess p18 growth-suppressor gene alterations in hematological neoplasms, we investigated 31 lymphoma and leukemia cell lines by...

journal_title：Leukemia research

authors： Siebert R,Willers CP,Fosså A,Kloke O,Nowrousian MR,Seeber S,Opalka B

更新日期：1996-02-01 00:00:00

abstract：:Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxicity in human acute promyelocytic leukemia NB4 cells by early disturbance in mitochondrial function and oxidative stres...

journal_title：Leukemia research

authors： García-Pérez AI,Galeano E,Nieto E,Estañ MC,Sancho P

更新日期：2014-07-01 00:00:00

abstract：:The expression and release of adhesion molecules by acute myelogenous leukemia (AML) blasts was investigated in vitro. For most patients AML blasts expressed relatively low levels of membrane-bound L-selectin and Intercellular adhesion molecule 1 (ICAM-1), but their soluble forms were detected in the supernatants for ...

journal_title：Leukemia research

authors： Bruserud O,Ulvestad E

更新日期：1999-02-01 00:00:00

abstract：:As sensitization of leukemia cells with granulocyte colony-stimulating factor (G-CSF) can enhance the cytotoxicity of chemotherapy in myeloid malignancies, a pilot study was conducted in order to evaluate the effect of G-CSF priming combined with low-dose chemotherapy in patients with higher risk myelodysplastic syndr...

journal_title：Leukemia research

authors： Wang FX,Zhang WG,He AL,Cao XM,Chen YX,Zhao WH,Yang Y,Wang JL,Zhang PY,Gu LF

更新日期：2016-09-01 00:00:00

abstract：:The acid phosphatase (AP), beta-glucuronidase (BG), and alpha-naphthyl-acetate esterase (ANAE) distribution and the morphology of stage 0 B-CLL lymphocytes were studied. The results were compared with the same hydrolase equipment and morphology of normal B-cell populations showing the B-CLL-like phenotype, and thus re...

journal_title：Leukemia research

authors： Palestro G,Novero D,Godio L,Micca FB,Resegotti L,Stramignon A

更新日期：1987-01-01 00:00:00

abstract：:The term "refractory anemia" was used in 1937 by Cornelius Parker Rhoads to describe patients whose anemia did not improve after treatment with liver extract or iron salts, and this term has been used to denote patients with certain subtypes of myelodysplastic syndromes (MDS) since the 1976 and 1982 French-American-Br...

journal_title：Leukemia research

authors： Steensma DP

更新日期：2016-12-01 00:00:00

abstract：:Human lymphocyte antigen-G (HLA-G) is an immunosuppressive molecule that induces functional silencing of immune component cells and can be responsible for immunosuppression in patients with multiple myeloma (MM). Immune dysfunction is an important feature of MM and leads to infections as well as may promote disease pr...

journal_title：Leukemia research

authors： Wlasiuk P,Stec A,Piechnik A,Kaminska W,Dmoszynska A,Ksiazek A,Giannopoulos K

更新日期：2012-07-01 00:00:00

abstract：:Pericardial effusion is a rare but potentially life-threatening complication of chronic myelomonocytic leukemia. A case of a 70-year-old female with CMML is reported, who developed a severe pericardial effusion after an initially stable course of disease. She underwent pericardiocentesis and subsequent intracardial in...

journal_title：Leukemia research

authors： Strupp C,Germing U,Trommer I,Gattermann N,Aul C

更新日期：2000-12-01 00:00:00

abstract：:Normal human monocytes express Fas and are susceptible to Fas ligand (FasL)-induced apoptosis. Because the myeloid leukemia cell lines HL-60 and THP-1 can be differentiated into functional monocytes and macrophages, we studied their expression of Fas and Fas ligand (FasL) to determine whether there were differentiatio...

journal_title：Leukemia research

authors： Bremner TA,Chatterjee D,Han Z,Tsan MF,Wyche JH

更新日期：1999-10-01 00:00:00