Abstract:
:KN-62, an inhibitor of the calmodulin-dependent protein kinases (CaMKs), enhances the terminal differentiation of retinoic acid sensitive human myeloid leukemia cell lines. In an effort to identify additional CaMK inhibitors that exhibit more potent activity in triggering leukemia cell differentiation, we synthesized 45 analogues of KN-62 and determined their ability to induce HL-60 cell differentiation. Sixteen of these novel analogues exhibited significant differentiation-inducing activity, and one analogue, AS-004, was five times more potent than KN-62 in inhibiting proliferation and inducing differentiation of HL-60 cells. Such KN-62 analogues and/or related compounds may prove useful in treating promyelocytic leukemia.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Schuler AD,Si J,Mueller L,Simon JA,Collins SJdoi
10.1016/j.leukres.2006.07.022subject
Has Abstractpub_date
2007-05-01 00:00:00pages
683-9issue
5eissn
0145-2126issn
1873-5835pii
S0145-2126(06)00282-7journal_volume
31pub_type
杂志文章abstract::Predisposition to lymphomagenesis is a well-known phenomenon of ataxia-telangiectasia, a recessive disorder caused by germline inactivation of ATM. ATM encodes a protein implicated in the repair of radiation induced double-strand breaks. Biallelic ATM inactivation was described also in sporadic lymphoid malignancies, ...
journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 信件
doi:10.1016/j.leukres.2005.11.025
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(82)90098-4
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2012.12.003
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.08.023
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2018.11.018
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
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abstract::Despite high rates of hematologic and cytogenetic responses to imatinib therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of Ph-positive leukemia. The high frequency of BCR-ABL mutations and amplifications represents the high degree of heterogeneity in patients wi...
journal_title:Leukemia research
pub_type: 杂志文章,评审
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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abstract::The oral bacterium, Aggregatibacter actinomycetemcomitans, produces a leukotoxin (LtxA) that is specific for white blood cells (WBCs) from humans and Old World primates by interacting with lymphocyte function antigen-1 (LFA-1) on susceptible cells. To determine if LtxA could be used as a therapeutic agent for the trea...
journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
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abstract::Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration wit...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.11.018
更新日期:2007-07-01 00:00:00
abstract::This study was aimed to illustrate the significance of minimal residual disease (MRD) assessment on day 22 in childhood acute lymphoblastic leukemia. MRD were measured on day 22, day 36, week 12, month 6 and month 12 by four-color flow cytometry. The 5-year cumulative incidence of relapse was significantly different f...
journal_title:Leukemia research
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