Abstract：
:The serum levels of interleukin 6 (IL6) are known to be elevated in two diseases of the elderly age, myelodysplastic syndrome (MDS) and multiple myeloma (MM). Authors suppose that one of the possible causes of this elevation could be a difference between these patients and healthy subjects in the frequency of polymorphic variants of the genes regulating IL6 levels. Scarce and contradictory comparative data are available for MM and to our best knowledge this is the first study on IL6 promoter and IL6 receptor (IL6R) polymorphism in MDS. Therefore we determined the Asp358Ala polymorphism of the IL6 receptor gene and the -174 G>C promoter polymorphism of the IL6 gene in blood samples of 102 MDS and 100 MM patients and 99 age- and sex-matched hospitalized controls had been tested for this purpose as well. There was no significant difference between patients with either disease and controls regarding IL6 promoter/L-6R. Authors therefore assume other mechanisms causing high IL6 levels are not related to either of these polymorphisms. Moreover authors consider important to propose a hypothesis how elements of signal transduction in iron metabolism might be involved in the development of MM and MDS in elderly age.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Aladzsity I,Kovács M,Semsei A,Falus A,Szilágyi A,Karádi I,Varga G,Füst G,Várkonyi Jdoi
10.1016/j.leukres.2009.03.009subject
Has Abstractpub_date
2009-11-01 00:00:00pages
1570-3issue
11eissn
0145-2126issn
1873-5835pii
S0145-2126(09)00117-9journal_volume
33pub_type
杂志文章abstract：:Activating mutations of Fms-like tyrosine kinase 3 (Flt3) are the most common genetic abnormalities found in acute myeloid leukemia (AML) and represent potential therapeutic targets. The novel Flt3 inhibitor KRN383 inhibited the autophosphorylation of Flt3 bearing internal tandem duplications (ITDs) and the Asp835Tyr ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.02.028
更新日期：2006-12-01 00:00:00
abstract：:Forty patients with high risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) preceded by MDS were treated with intensive induction and consolidation chemotherapy in a prospective multicenter pilot study. They were given two cycles of cytarabine 100 mg/m with 12-h intervals on days 1-7 and idarubicin 12...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0145-2126(96)00116-6
更新日期：1997-02-01 00:00:00
abstract：:Flow cytometry is commonly used to establish the diagnosis of chronic lymphocytic leukemia (CLL). A defined combination of antibodies discriminates between normal B cells and CLL cells (coexpression of CD5, CD19, and CD23). The receptor tyrosine-like orphan receptor one (ROR1) is an embryonic glycoprotein involved in ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2011.04.006
更新日期：2011-10-01 00:00:00
abstract：:Appropriate treatment for nonreactive thrombocytosis resulting from a myeloproliferative disorder (MPD) is surrounded by controversy. Although few doubt the association of thrombocytosis with increased risk for life-threatening events such as thrombosis or hemorrhage, or the association between clonal myeloproliferati...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2004.10.002
更新日期：2005-05-01 00:00:00
abstract：:We have previously shown that forced expression of the transcription factor Scl in WEHI-3B D(+) cells prevents ATRA-induced cell differentiation. We now find that the overexpression of Rbtn2 also interferes with induction of differentiation by ATRA. Addition of LiCl to ATRA treatment restored the capacity of both Scl-...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2003.08.011
更新日期：2004-04-01 00:00:00
abstract：:A total of 854 patients with anti-HTLV-I antibody positive ATL, newly diagnosed from 1983 to 1987, were analyzed for prognostic factors. There were 466 males and 388 females with a mean age of 57.1. Of these 269 (31.5%) were alive with a median follow-up time of 14 months from diagnosis, while 585 (65.5%) were dead wi...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90087-a
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Better risk-stratification of patients with chronic lymphocytic leukemia (CLL) and identification of subsets of ultra-high-risk (HR)-CLL patients are crucial in the contemporary era of an expanded therapeutic armamentarium for CLL. METHODS:A multivariate patient similarity network and clustering was applied...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2019.02.005
更新日期：2019-04-01 00:00:00
abstract：:Leukemic blasts of two patients with acute leukemia exhibited similar characteristics. They were heterogeneous in size with a diameter of 14-30 microns in smears and unclassifiable by morphological, cytochemical, immunophenotypic and ultrastructural examinations. Cytogenetic examinations of both revealed a near-tetrap...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90087-6
更新日期：1994-07-01 00:00:00
abstract：:N-Propyl-N-nitrosourea (PNU) was proved to be a strong leukemogen, which induces myelogenous leukemia or thymic lymphoma in rats. BUF/Mna rats and F344 rats were the strain most susceptible to thymic lymphomagenic activity of PNU. In addition, F1 rats between BUF/Mna and WKY rats were also susceptible to PNU-lymphomag...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(88)90091-4
更新日期：1988-01-01 00:00:00
abstract：:We have studied the survival of clonogenic neoplastic cells of a murine pre-B-lymphoma (BCl-1) of the spleen in culture. We have found quantitative deficiencies such as reduced surface adherence of stromal cells and impaired CFU-F (colony forming units-fibroblast) and pre-CFU-F colony and layer formation in stromal cu...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90088-3
更新日期：1993-07-01 00:00:00
abstract：OBJECTIVES:Follicular lymphoma (FL) is generally considered an indolent disorder but a significant subset of patients shows a worse outcome. Aim of this study was to validate the FLIPI score in an independent series of follicular lymphoma patients and to correlate prognostic categories with the period of diagnosis and ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.07.006
更新日期：2006-03-01 00:00:00
abstract：:Ectopic expression of LMO2 occurs in approximately 45% of T-lineage acute lymphoblastic leukemias (T-ALL), sometimes in association with chromosomal translocations. Recently, a lymphoproliferative disorder developed in two participants in a gene therapy trial due to LMO2 activation via integration of the retroviral ve...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2004.05.013
更新日期：2005-01-01 00:00:00
abstract：:This study investigated radioresistance mechanisms in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100. AML-2/DX100 also showed resistance to radiation. AML-2/DX100 characterized by down-regulated catalase expression was supersensitive to exogenous hydrogen peroxide whereas they increased defense mec...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.11.006
更新日期：2007-09-01 00:00:00
abstract：:We analyzed the biological activity of HA14-1, a small organic compound inhibitor of Bcl-2, against established leukaemia cell lines and blasts from acute myeloid leukaemia (AML) patients. HA14-1 had a potent killing activity against the leukaemia cell line that expressed endogenous or ectopic Bcl-2. This activity was...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.11.010
更新日期：2007-06-01 00:00:00
abstract：:Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in folate metabolism and DNA methylation. Studies on MTHFR polymorphism in leukemia have largely focused on the protective role of MTHFR polymorphism in acute lymphoblastic leukemia (ALL). We evaluated the C677T and A1298C polymorphisms using the TaqMan...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.10.016
更新日期：2007-09-01 00:00:00
abstract：:K-562 is described as a pluripotent leukemic cell line which expresses a diversity of hematopoietic cell differentiation antigens. With the use of monoclonal antibodies (MoAb), we show that the expression of these antigens is either "modulated", i.e. they are not expressed in early logarithmic growth but are expressed...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90181-0
更新日期：1987-01-01 00:00:00
abstract：:The development of risk-adapted therapy has improved the treatment results of acute lymphoblastic leukemia (ALL) especially in children. However, more accurate risk classifiers are warranted. In this study we aimed at defining a prognostic classifier based on DNA copy number alterations of adolescent and young adult (...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2010.02.031
更新日期：2010-11-01 00:00:00
abstract：:Although there has been much progress in the treatment of acute lymphoblastic leukemia (ALL), decreased sensitivity to chemotherapy remains a significant issue. Recent studies have shown how interactions with the bone marrow microenvironment can protect ALL cells from chemotherapy and allow for the persistence of the ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.01.030
更新日期：2017-05-01 00:00:00
abstract：:The impact of socioeconomic status (SES) upon childhood cancer outcomes has not been extensively examined. Our objective was to determine the association between SES and event-free survival (EFS) among children with acute lymphoblastic leukemia (ALL) diagnosed in Ontario, Canada from 1995-2011 (N=1541) using Cox propo...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.leukres.2014.08.017
更新日期：2014-12-01 00:00:00
abstract：:Pro-apoptotic signalling upon toll-like receptor (TLR) stimulation in myeloid cells is normally antagonized by the simultaneous activation of anti-apoptotic pathways. We have previously reported that IFN-alpha can sensitize human monocytes to apoptosis induction by lipopolysaccharide (LPS). Based on these results we i...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.05.001
更新日期：2007-12-01 00:00:00
abstract：:Aberrant expression of tumor suppressor genes WT 1, RB 1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML 1, MLL-AF 4, E2A-PBX 1, SIL-TAL 1 were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblasti...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.04.006
更新日期：2005-11-01 00:00:00
abstract：:Ml cells were labeled in vitro with [3H]thymidine and injected into the peritoneal cavity of syngeneic mice. After several days the peritoneal cells were harvested and [3H]labeled cells were determined by autoradiography. The inoculated isotope-labeled Ml cells differentiated in the peritoneal cavity and lipopolysacch...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(82)90050-9
更新日期：1982-01-01 00:00:00
abstract：:HSP90 is a multi-client chaperone involved in regulating a large array of cellular processes and is commonly overexpressed in many different cancer types including hematological malignancies. Inhibition of HSP90 holds promise for targeting multiple molecular abnormalities and is therefore an attractive target for hete...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.03.016
更新日期：2015-06-01 00:00:00
abstract：:Chromosomal changes are necessary in determining the classification, prognosis and using the appropriate therapeutic regimen in acute leukemia. Isochromosomes are uncommon chromosome aberations in childhood acute lymphoblastic leukemia (ALL) and the effect of i(9q) is not well established. We present an 8-year-old mal...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.02.018
更新日期：2006-11-01 00:00:00
abstract：:Many patients with multiple myeloma (MM) are elderly (aged >65 years) or unfit, and therefore ineligible for stem-cell transplantation. The novel agents thalidomide, bortezomib, and lenalidomide have shown improved outcomes in these patients. This article discusses the role of continuous therapy in improving patient o...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/S0145-2126(12)70005-X
更新日期：2012-11-01 00:00:00
abstract：:The basis of intrinsic resistance of blasts from patients with acute non-lymphocytic leukemia (ANLL) to methotrexate was studied. MTX polyglutamate formation was measured in blast cells from 19 patients with ANLL and in 7 pediatric patients with acute lymphocytic leukemia (ALL), after in vitro incubation for 24 h with...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90189-z
更新日期：1991-01-01 00:00:00
abstract：:Outcome of adult acute lymphoblastic leukemia (ALL) with central nervous system (CNS) involvement is not clearly defined. We studied 104 patients presenting with CNS involvement at diagnosis among 1493 patients (7%) included into the LALA trials, and 109 patients presenting CNS disease at the time of first relapse amo...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2008.04.011
更新日期：2008-11-01 00:00:00
abstract：:Pyothorax-associated lymphoma (PAL) is a representative form of diffuse large B-cell lymphoma associated with chronic inflammation, in which the Epstein-Barr virus (EBV) genome is consistently detectable in the lymphoma cells of all PAL cases. Cell lines and animal models would be useful for understanding better this ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.07.033
更新日期：2013-11-01 00:00:00
abstract：:Recombinant TNF was capable of inducing differentiation of human leukemic ML-1 cells in the monocytic pathway. Recombinant interleukin 6 did not have the activity but it could significantly increase the activity of recombinant TNF. Both of these molecules were found to play a similar role in PWM-induced conditioned me...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(90)90010-7
更新日期：1990-01-01 00:00:00
abstract：:This retrospective study of the thrombocythemia Italian registry (RIT) documented that 71 (30.6%) out of 232 ET patients experienced 88 cardiovascular adverse events (CV-AEs) during anagrelide treatment (522 pt-y). The rate of CV-AEs was: 24.1% for palpitations, 4.3% for angina, 3.5% for arterial hypertension, 3.0% fo...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2011.06.030
更新日期：2011-12-01 00:00:00
