当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Long-term follow-up of intensive ara-C-based chemotherapy followed by bone marrow transplantation for adult acute lymphoblastic leukemia: impact of induction Ara-C dose and post-remission therapy.

Long-term follow-up of intensive ara-C-based chemotherapy followed by bone marrow transplantation for adult acute lymphoblastic leukemia: impact of induction Ara-C dose and post-remission therapy.

Abstract：

:We report single institution outcome of brief, intensive ara-C-based chemotherapy using bone marrow transplantation as primary intensification for untreated adult patients with acute lymphoblastic leukemia (ALL). Overall disease-free and overall survival were inferior to those reported with prolonged chemotherapy modeled on pediatric protocols. Survival and disease-free survival were superior for patients receiving allogeneic BMT compared with chemopurged autologous transplant or maintenance chemotherapy (patients ineligible for or declining BMT). In multivariate analysis, non-L2-FAB, higher ara-C dose, absence of CNS disease, non-Ph1+ karyotype, allogeneic BMT, T cell phenotype, and younger age were associated with improved disease-free survival. Autologous BMT was not superior to chemotherapy, and appears unlikely to provide adequate curative treatment for most adult ALL patients if not followed by maintenance.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Sotomayor EM,Piantadosi S,Miller CB,Karp JE,Jones RJ,Rowley SD,Kaufmann SH,Braine H,Burke PJ,Gore SD

doi

10.1016/s0145-2126(01)00175-8

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

461-71

issue

5

eissn

0145-2126

issn

1873-5835

pii

S0145212601001758

journal_volume

26

pub_type

杂志文章

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