Nilotinib post-liver transplantation for acute hepatic failure related to imatinib.

abstract：:Dose reductions or interruptions may be required to manage treatment-associated adverse events among patients with myelodysplastic syndromes (MDS) treated with lenalidomide; such modifications are recommended to sustain therapy and maximize treatment duration. The aim of this retrospective case-control study was to de...

journal_title：Leukemia research

authors： DeZern AE,Binder G,Ni Q,McGuire M,Smith BD

更新日期：2017-12-01 00:00:00

abstract：:Despite initial remissions, most patients with Ph chromosome positive (Ph(+)) acute leukemia (AL) become refractory to tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib. This study was designed to determine if targeting the interleukin-3 receptor (IL-3R) with a diphtheria toxin fusion protein (DT(388)IL...

journal_title：Leukemia research

authors： Kim HP,Frankel AE,Hogge DE

更新日期：2010-08-01 00:00:00

abstract：:Hematopoiesis is regulated by several cytokines with pleiotropic activity. Several evidences have clearly demonstrated that these molecules, formerly regarded as specific for the hematopoietic system, also affect certain endothelial cell functions and that hematopoietic factors clearly influence angiogenesis. This rev...

journal_title：Leukemia research

authors： Ribatti D

更新日期：2012-05-01 00:00:00

abstract：:The impact of socioeconomic status (SES) upon childhood cancer outcomes has not been extensively examined. Our objective was to determine the association between SES and event-free survival (EFS) among children with acute lymphoblastic leukemia (ALL) diagnosed in Ontario, Canada from 1995-2011 (N=1541) using Cox propo...

journal_title：Leukemia research

authors： Gupta S,Sutradhar R,Guttmann A,Sung L,Pole JD

更新日期：2014-12-01 00:00:00

abstract：:A primary mitochondrial defect may be pivotal in the pathogenesis of acquired idiopathic sideroblastic anemia (AISA). The mitochondrial respiratory chain is involved in mitochondrial iron uptake and supply of ferrous iron (Fe2+) for heme synthesis. Mitochondrial DNA (mtDNA) comes into play because several subunits of ...

journal_title：Leukemia research

authors： Gattermann N

更新日期：2000-02-01 00:00:00

abstract：:Medullary dyserythropoiesis with reduced production of erythrocytes is an early and consistent feature of myelodysplastic syndromes (MDS). The mechanism underlying the disturbed red cell proliferation and maturation is presently unknown. In order to study the role of erythropoietic growth factors, we determined by rad...

journal_title：Leukemia research

authors： Aul C,Arning M,Runde V,Schneider W

更新日期：1991-01-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) and 25% of adult onset acute lymphoblastic leukemia (ALL) are associated with the expression of Bcr-Abl, a constitutively activated protein tyrosine kinase. Bcr-Abl associated leukemias are characterized by a high degree of chromosomal and genomic instability. It is unclear if the ph...

journal_title：Leukemia research

authors： Brain J,Saksena A,Laneuville P

更新日期：2002-11-01 00:00:00

abstract：:We compared the growth-inhibitory effects and inhibition profile of the SRC family kinases (SFKs) of imatinib, dasatinib, nilotinib and INNO-406. Dasatinib exhibited the strongest potency against BCR-ABL with little selectivity over SFKs. Nilotinib exhibited a weaker affinity than the other inhibitors, but was highly ...

journal_title：Leukemia research

authors： Deguchi Y,Kimura S,Ashihara E,Niwa T,Hodohara K,Fujiyama Y,Maekawa T

更新日期：2008-06-01 00:00:00

abstract：:We established a plasmacytoid dendritic cell (pDC) line (PMDC05) from leukemia cells of pDC leukemia. PMDC05 cells were positive for CD4, CD56, CD33, HLA-DR, CD123 (IL-3Ralpha) and CD86 in the absence of lineage markers. mRNA of TLR1, TLR2, TLR4, TLR7 and TLR9 was clearly expressed and among these TLRs, TLR7 was promi...

journal_title：Leukemia research

authors： Narita M,Watanabe N,Yamahira A,Hashimoto S,Tochiki N,Saitoh A,Kaji M,Nakamura T,Furukawa T,Toba K,Fuse I,Aizawa Y,Takahashi M

更新日期：2009-09-01 00:00:00

abstract：:The surface marker phenotype of lymphocytes derived from 12 patients with B-CLL was compared to that of lymphocytes from 10 patients with an other monoclonal but clinical benign form of B-cell proliferative disorder termed monoclonal B-cell lymphocytosis of undetermined significance (B-MLUS). A panel of well character...

journal_title：Leukemia research

authors： Garcia C,Rosén A,Kimby E,Aguilar-Santelises M,Jondal M,Bjorkholm M,Holm G,Mellstedt H

更新日期：1989-01-01 00:00:00

abstract：:Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients >or=10...

journal_title：Leukemia research

authors： Choi J,Hwang YK,Sung KW,Kim DH,Yoo KH,Jung HL,Koo HH

更新日期：2006-08-01 00:00:00

abstract：:Two AML patients, whose leukemic clonogenic cells totally reacted to the anti-lactofucopentaose III S4-7 monoclonal antibody (MoAb), underwent autologous bone marrow transplantation, in first complete remission, after in-vitro purging with S4-7 MoAb and complement. After ablative chemotherapy (BAVC regimen) and reinfu...

journal_title：Leukemia research

authors： Ferrero D,De Fabritiis P,Amadori S,De Felice L,Gallo E,Meloni G,Pregno P,Pulsoni A,Simone F,Tarella C

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Better risk-stratification of patients with chronic lymphocytic leukemia (CLL) and identification of subsets of ultra-high-risk (HR)-CLL patients are crucial in the contemporary era of an expanded therapeutic armamentarium for CLL. METHODS:A multivariate patient similarity network and clustering was applied...

journal_title：Leukemia research

authors： Turcsanyi P,Kriegova E,Kudelka M,Radvansky M,Kruzova L,Urbanova R,Schneiderova P,Urbankova H,Papajik T

更新日期：2019-04-01 00:00:00

abstract：:This prospective phase II clinical trial evaluated the effects of single-dose mitoxantrone (36 mg/m2 on day 1) in combination with continuous infusion intermediate-dose cytarabine plus etoposide in 25 patients with refractory or early relapsed acute myeloid leukemia (AML). We compared the results of our current study ...

journal_title：Leukemia research

authors： Lee SS,Lee JH,Lee JH,Kim DY,Kim SH,Lim SN,Lee YS,Seol M,Ryu SG,Kang YA,Jang S,Park CJ,Chi HS,Yun SC,Lee KH

更新日期：2009-04-01 00:00:00

abstract：:We investigated the possible influence of recombinant (r) sIL-6R on the growth of three IL-6 non-responsive or weakly IL-6 responsive long-term myeloma cell lines. The three cell lines chosen for the study (U266, L363 and Fravel) all expressed gp130 but differed in their expression of IL-6R and IL-6. mRNA analysis by ...

journal_title：Leukemia research

authors： Diamant M,Hansen MB,Rieneck K,Svenson M,Yasukawa K,Bendtzen K

更新日期：1996-04-01 00:00:00

abstract：:Adult T-cell leukemia (ATL) is an aggressive malignancy of peripheral T cells infected with human T-cell leukemia virus type 1 (HTLV-1). The prognosis of patients with aggressive ATL remains poor because ATL cells acquire resistance to conventional cytotoxic agents. Therefore, development of novel agents is urgently n...

journal_title：Leukemia research

authors： Sasaki R,Ito S,Asahi M,Ishida Y

更新日期：2015-12-01 00:00:00

abstract：:The methylation inhibitor decitabine (DAC) has great therapeutic value for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, DAC monotherapy is associated with relatively low rates of overall response and complete remission. Previous studies have shown promising results for combination treatmen...

journal_title：Leukemia research

authors： Geng S,Yao H,Weng J,Tong J,Huang X,Wu P,Deng C,Li M,Lu Z,Du X

更新日期：2016-05-01 00:00:00

abstract：:Exogenous expression of the transcription factor Scl (Tal1) in WEHI-3B D+ myelomonocytic leukemia cells interferes with their capacity to respond to all-trans retinoic acid (ATRA) induced differentiation; combination of ATRA with LiCl, however, circumvents the inhibition of differentiation produced by Scl. To gain inf...

journal_title：Leukemia research

authors： Rice AM,Holtz KM,Karp J,Rollins S,Sartorelli AC

更新日期：2004-11-01 00:00:00

abstract：:A prospective case-control study of the aetiologic factors involved in the production of lymphoid malignancies has been conducted within a defined geographical area covering six health districts in the Yorkshire Region. Among the aspects investigated were past medical events, occupations and certain social factors. A ...

journal_title：Leukemia research

authors： Bernard SM,Cartwright RA,Bird CC,Richards ID,Lauder I,Roberts BE

更新日期：1984-01-01 00:00:00

abstract：:The importance of IL-18, although clearly established in solid tumors, has not been fully elucidated in human hematopoietic neoplasms. Here we examined the mRNA and protein for IL-18 in eight human hematopoietic cell lines representing different lineages and neoplasms including leukemia, lymphoma and others. Our resul...

journal_title：Leukemia research

authors： Zhang B,Ma XT,Zheng GG,Li G,Rao Q,Wu KF

更新日期：2003-09-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Leukemia research

authors： Zengwang,Zhou HJ,Li A,Zhang JL

更新日期：2009-02-20 00:00:00

abstract：:Analgesic use has been implicated in the chemoprevention of a number of solid tumors, but to date no previous research has focused on the role of analgesics in the etiology of multiple myeloma (MM). We conducted a hospital-based case-control study of 117 patients with primary, incident MM and 483 age and residence mat...

journal_title：Leukemia research

authors： Moysich KB,Bonner MR,Beehler GP,Marshall JR,Menezes RJ,Baker JA,Weiss JR,Chanan-Khan A

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Chronic Myeloid Leukemia (CML) is characterized by the overproduction of BCR-ABL, a tyrosine kinase with constitutive activity, in which the majority of CML patients have e13a2 or e14a2 transcripts. Reckoned the possible associations between the hematologic and molecular features of the disease, a profound u...

journal_title：Leukemia research

authors： Ghalesardi OK,Khosravi A,Azizi E,Ahmadi SE,Hajifathali A,Bonakchi H,Shahidi M

更新日期：2021-01-19 00:00:00

abstract：:Pycnogenol, rich of many phytochemicals of medical value, is a commercialized nutrient supplement extracted from the bark of European coastal pine. In this study, we investigated the anti-tumor effects of Pycnogenol on HL-60, U937 and K562 human leukemia cell lines. We found that Pycnogenol inhibited cell proliferatio...

journal_title：Leukemia research

authors： Huang WW,Yang JS,Lin CF,Ho WJ,Lee MR

更新日期：2005-06-01 00:00:00

abstract：:Glycosylation of cytokines appears to be responsible for several differences in their activity, and focusing on G-CSF, several divergences between the non-glycosylated G-CSF, Filgrastim, and the glycosylated G-CSF, Lenograstim, have been reported. To verify the role of G-CSF glycosylation in mediating these difference...

journal_title：Leukemia research

authors： Mattii L,Battolla B,Azzarà A,D'Urso G,Montali U,Petrini M

更新日期：2011-02-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) may be underreported in cancer registries such as the Netherlands Cancer Registry (NCR). Analysis of Dutch medical claims can complement NCR data on MDS and CMML. We analyzed data on 3681 MDS patients and 235 CMML patients aged ≥18 years with i...

journal_title：Leukemia research

authors： Dinmohamed AG,van Norden Y,Visser O,Posthuma EF,Huijgens PC,Sonneveld P,van de Loosdrecht AA,Jongen-Lavrencic M

更新日期：2015-02-01 00:00:00

abstract：:The incidence of B cell chronic lymphocytic leukemia (B-CLL) is lower in Asian countries, including India, when compared with Western countries. The bcl-2 gene rearrangement was restricted to the 5' region and seen in only one of the 20 Indian patients analyzed. The incidence remains similar to that reported from West...

journal_title：Leukemia research

authors： Parikh PM,Desai S,Naresh KN,Shakuntaka B,Laxminarayan K,Nair CN,Ladanyi M,Soman CS,Advani SH,Chaganti RS

更新日期：1996-09-01 00:00:00

abstract：:A rare case of a 46-year-old man who underwent myelodysplastic syndrome, acute monocytic leukemia with FLT3-ITD mutation and splenic disruption following orthotopic liver transplantation is reported. The study of this case may be helpful to understand both the pathogenesis of acute leukemia and new complication of liv...

journal_title：Leukemia research

authors： Zhang GS,Dai CW,Peng HL,Xu YX,Pei MF

更新日期：2006-07-01 00:00:00

abstract：:Acute monocytic leukemia (M5) is a subtype of acute myeloid leukemia (AML) with two distinct morphologic subcategories, M5a and M5b. We compared the immunophenotype, cytogenetics and clinical outcome of AML M5 with non-M5 AML and also compared M5a with M5b. One hundred and twelve M5 (76 M5a, 36 M5b) and 726 non-M5 cas...

journal_title：Leukemia research

authors： Villeneuve P,Kim DT,Xu W,Brandwein J,Chang H

更新日期：2008-02-01 00:00:00

abstract：:We have isolated an M-CSF-like membrane-associated growth factor from human leukemic J6-1 cells that can enhance the growth and colony formation of J6-1 cells in vitro. Indirect evidence suggests that this membrane-associated M-CSF-like growth factor may do so by stimulating a corresponding receptor co-expressed on th...

journal_title：Leukemia research

authors： Wu KF,Rao Q,Zheng GG,He ZH,Ying HG,Song YH,Chen BD

更新日期：1998-01-01 00:00:00