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Telomerase gene screening and telomere overhang detection in Chinese patients with myelodysplastic syndrome.

Abstract：

BACKGROUND:Telomerase disfunction leads to short telometric overhangs, potentially resulting in chromosome instability. AIMS:To better understand the role of overhang length in the progression of myelodysplastic syndrome (MDS). METHODS:Bone marrow samples of 62 Chinese MDS patients were screened for TERT and TERC gene variants. Overhangs length was investigated. RESULTS:No mutation was identified. MDS patients had shorter overhangs compared to controls. Abnormal karyotype ones had shorter overhang compared to normal. Telomeric overhang length decreased as IPSS/WPSS value increased. CONCLUSIONS:Overhang changes in accordance with IPSS/WPSS in MDS. Short overhang may be an independent factor for poor prognosis in MDS.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Yan S,Han B,Li H,Wu Y,Zhou D,Zhao Y

doi

10.1016/j.leukres.2013.06.011

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

1359-62

issue

10

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(13)00197-5

journal_volume

37

pub_type

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