Analysis of clonality at the level of progenitors in chronic myelogenous leukaemia using the polymerase chain reaction.

abstract：:FcRIII (CD16) expression on neutrophils from 17 patients with chronic myeloid leukemia (CML) was studied by flow cytometry using monoclonal antibodies. A variable proportion of CD16-negative neutrophils were found both in CML patients in chronic phase (3 out of 8 patients) and in CML patients in hematological remissio...

journal_title：Leukemia research

authors： Carulli G,Gianfaldoni ML,Azzara A,Papineschi F,Vanacore R,Minnucci S,Testi R,Ambrogi F

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders, with very different prognosis in given individuals; age and comorbidities are emerging as relevant patient-related factors influencing clinical outcome in MDS. Our aim was to evaluate the impact of age, comorbidities and disease s...

journal_title：Leukemia research

authors： Balleari E,Salvetti C,Del Corso L,Filiberti R,Bacigalupo A,Bellodi A,Beltrami G,Bergamaschi M,Berisso G,Calzamiglia T,Carella AM,Cavalleri M,Da Col A,Favorini S,Forni GL,Goretti R,Miglino M,Mitscheuning L,Molinari E,

更新日期：2015-08-01 00:00:00

abstract：:Fifty-three patients with Ph positive chronic myeloid leukaemia in blastic phase were studied. Additional abnormalities were found in 29 (55%) patients and were more common in myeloid (64%) than lymphoid (45%) blast crisis. The most frequent were +Ph (32%), +8 (28%), +19 (19%), +20 (9%) and +21 (9%). i(17q) (9%) was a...

journal_title：Leukemia research

authors： Nanjangud G,Kadam PR,Saikia T,Bhisey AN,Kumar A,Gopal R,Chopra H,Nair CN,Advani SH

更新日期：1994-05-01 00:00:00

abstract：:Acute myeloid leukemia is an aggressive disease that arises from clonal expansion of malignant hematopoietic precursor cells of the bone marrow. Deletions on the long arm of chromosome 9 (del(9q)) are observed in 2% of acute myeloid leukemia patients. Our deletion analysis in a cohort of 31 del(9q) acute myeloid leuke...

journal_title：Leukemia research

authors： Naarmann-de Vries IS,Sackmann Y,Klein F,Ostareck-Lederer A,Ostareck DH,Jost E,Ehninger G,Brümmendorf TH,Marx G,Röllig C,Thiede C,Crysandt M

更新日期：2019-01-01 00:00:00

abstract：:Infant leukemia cells with 46XY,t(11; 17)(q23; p13) karyotype and a hybrid pre B myeloid phenotype (HLA-DR, (Ia), B4 and My7-positive and CALLA and T11-negative) and immunoglobulin heavy chain gene rearrangement were maintained in long-term culture for over 10 months. The in-vitro survival and growth of the leukemia c...

journal_title：Leukemia research

authors： Umiel T,Friedman S,Zaizov R,Cohen IJ,Gozes Y,Epstein N,Kobiler D,Zipori D

更新日期：1986-01-01 00:00:00

abstract：:We report a patient with Philadelphia chromosome positive (Ph +ve) chronic myelogenous leukemia (CML), treated with hydroxyurea alone, who upon disease progression developed an additional Ph - ve clone containing chromosomal abnormalities typical of myelodysplastic syndrome (MDS). Retrospective analysis of a cryoprese...

journal_title：Leukemia research

authors： Flamm MJ,Murty VV,Rao PH,Nichols GL

更新日期：2002-04-01 00:00:00

abstract：:The oral bacterium, Aggregatibacter actinomycetemcomitans, produces a leukotoxin (LtxA) that is specific for white blood cells (WBCs) from humans and Old World primates by interacting with lymphocyte function antigen-1 (LFA-1) on susceptible cells. To determine if LtxA could be used as a therapeutic agent for the trea...

journal_title：Leukemia research

authors： Kachlany SC,Schwartz AB,Balashova NV,Hioe CE,Tuen M,Le A,Kaur M,Mei Y,Rao J

更新日期：2010-06-01 00:00:00

abstract：:Expression of p14(ARF) and p16(INK4a) tumor suppressor genes was investigated in 109 patients with chronic myeloid leukemia (CML). The p14(ARF) and p16(INK4a) mRNA levels were significantly low in patients in chronic phase (CP) at presentation and high in patients treated with interferon-alpha (IFN-alpha), especially ...

journal_title：Leukemia research

authors： Cividin M,Ayrault O,Sorel N,Séité P,Brizard F,Blanchet O,Mahon FX,Guilhot F,Larsen C,Chomel JC,Brizard A

更新日期：2006-10-01 00:00:00

abstract：:In order to investigate the clinical significance of IgG subclass levels in adult patients treated for acute lymphocytic (ALL) or myelogenous leukemias (AML), patients were tested before and in regular intervals during and after chemotherapy. Ten patients treated for acute lymphocytic leukemia had normal total IgG and...

journal_title：Leukemia research

authors： Gause A,Schmitz G,von Kalle AK,Lathan B,Diehl V,Pfreundschuh M

更新日期：1992-01-01 00:00:00

abstract：:Thrombohaemorrhagic complications are major clinical problems in the classical chronic Ph-negative myeloproliferative disorders (CMPDs), polycytaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF), contributing significantly to morbidity and mortality. Pathophysiologically these disorder...

journal_title：Leukemia research

authors： Hasselbalch HC,Riley CH

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Chromosomal aberrations at the ETV6 gene locus on 12p13.2 are common in bone marrow samples involved by blastic plasmacytoid dendritic cell neoplasm (BPDCN). However, their pathogenic role, incidence in cutaneous BPDCN lesions, and clinical significance have not been assessed systematically. RESULTS:The stu...

journal_title：Leukemia research

authors： Tang Z,Li Y,Wang W,Yin CC,Tang G,Aung PP,Hu S,Lu X,Toruner GA,Medeiros LJ,Khoury JD

更新日期：2018-10-01 00:00:00

abstract：:Preclinical data suggest that all-trans retinoic acid (ATRA) synergizing with granulocyte colony stimulating factor (G-CSF), can improve the effectiveness of chemotherapy in acute myeloid leukemia (AML). Fludarabine 15 mg/m(2) is the minimum dose able to optimize intensification with fludarabine-arabinosylcytosine reg...

journal_title：Leukemia research

authors： Montillo M,Ricci F,Tedeschi A,Cafro AM,Nosari AM,Nichelatti M,Marbello L,Morra E

更新日期：2009-08-01 00:00:00

abstract：:We report the case of an elderly patient affected by Philadelphia positive Acute Lymphoblastic Leukaemia (Ph(+) ALL) who developed meningeal leukaemia during imatinib monotherapy, despite bone marrow molecular remission. Aggressive central nervous system (CNS)-directed therapy in combination with continued imatinib tr...

journal_title：Leukemia research

authors： Mele G,Pinna S,Melpignano A,Romano A,Brocca MC,Coppi MR,Quarta G

更新日期：2007-10-01 00:00:00

abstract：:In order to establish diagnostic criteria for hypocellular acute leukemia (HL), we have reviewed 32 cases selected on the basis of hypothetical 40% or less cellularity, by focusing on morphology, immunophenotype, karyotype and response to low dose Ara-C (LDAC) regimen and compared them with 40 cases of myelodysplastic...

journal_title：Leukemia research

authors： Nagai K,Kohno T,Chen YX,Tsushima H,Mori H,Nakamura H,Jinnai I,Matsuo T,Kuriyama K,Tomonaga M,Bennett JM

更新日期：1996-07-01 00:00:00

abstract：:The chemicals 6-mercaptopurine (6-MP) and methotrexate (MTX) are the cornerstones in the maintenance treatment of acute lymphoblastic leukemia. The intracellular metabolism of 6-MP to 6-thioguanosine nucleotides (TGN) via 6-thioinosine 5'-monophosphate (TIMP) is crucial for its cytotoxic effect. MTX inhibits purine de...

journal_title：Leukemia research

authors： Liliemark J,Pettersson B,Peterson C

更新日期：1992-01-01 00:00:00

abstract：:It has been suggested that acidic isoferritins play a major role in the regulation of human granulocyte-macrophage (CFU-GM) proliferation. Such regulatory isoferritins are said to occur in some human tissues including both leukaemic and normal leucocytes, and certain established cell lines. They are glycosylated and b...

journal_title：Leukemia research

authors： Wyllie F,Jacobs A,Waradanukul K,Worwood M,Wagstaff M

更新日期：1984-01-01 00:00:00

abstract：:Nasal-type natural killer/T-cell (NK/T-cell) lymphomas are subtypes of non-Hodgkin's lymphoma (NHL), which are typically more clinically aggressive. There is, however relatively little understanding of nasal-type NK/T-cell lymphoma molecular pathogenesis. Thus, in this study we applied RNA sequencing to systematically...

journal_title：Leukemia research

authors： Zhang X,Zhao L,Li X,Wang X,Li L,Fu X,Sun Z,Li Z,Nan F,Chang Y,Zhang M

更新日期：2015-12-01 00:00:00

abstract：:The serum levels of interleukin 6 (IL6) are known to be elevated in two diseases of the elderly age, myelodysplastic syndrome (MDS) and multiple myeloma (MM). Authors suppose that one of the possible causes of this elevation could be a difference between these patients and healthy subjects in the frequency of polymorp...

journal_title：Leukemia research

authors： Aladzsity I,Kovács M,Semsei A,Falus A,Szilágyi A,Karádi I,Varga G,Füst G,Várkonyi J

更新日期：2009-11-01 00:00:00

abstract：:The prognosis of patients with advanced refractory lymphoma remains poor. We have carried out a Phase II study of continuous high dose intravenous recombinant interleukin 2 alone without LAK cells in this group of patients. Eight patients have so far been treated, 4 with non-Hodgkins lymphoma and 4 with Hodgkins disea...

journal_title：Leukemia research

authors： Lim SH,Worman CP,Callaghan T,Jewell A,Smith MP,Goldstone AH

更新日期：1991-01-01 00:00:00

abstract：:In-vitro infection of normal human lymphocytes with HTLV-I (human T-cell lymphotropic retrovirus type I) has been carried out to study the target cell specificity and the kinetics of infection. Cord blood (CBL) and adult peripheral blood lymphocytes (PBL) have been co-cultivated with irradiated HTLV-I donor cells (MT2...

journal_title：Leukemia research

authors： Del Mistro A,De Rossi A,Aldovini A,Salmi R,Chieco-Bianchi L

更新日期：1986-01-01 00:00:00

abstract：:We report a unique case of de novo acute promyelocytic leukemia (APL) with cryptic 15;17 rearrangements. Cytogenetically, structural rearrangements of the 6p23 region has been reported mainly in secondary leukemia. This patient had a karyotype of 46, XY, del(6)(p23) and no additional chromosomal abnormalities. Molecul...

journal_title：Leukemia research

authors： Nakase K,Wakita Y,Minamikawa K,Yamaguchi T,Shiku H

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:Jumping translocations are rare cytogenetic aberrations in haematological malignancies, the pathogenesis of which remains to be fully characterised. We investigated the mechanism of formation of jumping translocations in a case of adult common acute lymphoblastic leukaemia (ALL) positive for the Ph tran...

journal_title：Leukemia research

authors： Wan TS,Ma SK,Chow EY,Li YH,Lin SY,Chan LC

更新日期：2004-10-01 00:00:00

abstract：:In previous studies, HL60 AML cells treated with tumor necrosis factor-alpha (TNF), interferon-gamma (IFN), and lipopolysaccharides (LPS) displayed decreased growth and viability, enhanced monocytic pathway differentiation and endogenous TNF release. Endogenous TNF release by LPS/TNF/IFN treated HL60 cells was postula...

journal_title：Leukemia research

authors： Treon SP,Anand B,Ulevitch R,Broitman SA

更新日期：1994-01-01 00:00:00

abstract：:Bi-specific anti-CD33 x anti-CD64 antibodies (BsAb) mediated more potent and longer-lasting inhibition of proliferation of human leukemia cell lines and primary acute myeloid leukemia (AML) samples compared to mono-specific anti-CD33 mAb. There were no differences between these two antibodies in cellular internalizati...

journal_title：Leukemia research

authors： Balaian L,Ball ED

更新日期：2004-08-01 00:00:00

abstract：:Two white European males are reported with adult T-cell leukemia (ATL), a disease first described in Japan, but recently also in the U.K. and U.S.A. Both patients presented with lymphadenopathy, but without a mediastinal mass. In addition, one patient had skin infiltrates and the other had hepatosplenomegaly. Morpholo...

journal_title：Leukemia research

authors： Tricot GJ,Broeckaert-Van Orshoven A,den Ottolander GJ,de Wolf-Peeters C,Meyer CJ,Verwilghen RL,Jansen J

更新日期：1983-01-01 00:00:00

abstract：:Stromal cells from pediatric myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) associated with MDS (MDS-AML) present high expression of leukemia inhibitor factor (LIF). We demonstrated using mitogen-activated protein kinase (MAPK) inhibitors that in stromal cells from pediatric MDS and MDS-AML, p38MAPK ...

journal_title：Leukemia research

authors： da Costa SV,Roela RA,Junqueira MS,Arantes C,Brentani MM

更新日期：2010-04-01 00:00:00

abstract：:Aberrant promoter methylation may contribute to the hematopoietic disturbances in myelodysplastic syndromes (MDS). To explore a possible mechanism, we therefore analyzed expression of DNA methyltransferase (DNMT) subtypes kinetics and aberrant promoter methylation of key regulatory genes during MDS hematopoiesis. An i...

journal_title：Leukemia research

authors： Hopfer O,Komor M,Koehler IS,Freitag C,Schulze M,Hoelzer D,Thiel E,Hofmann WK

更新日期：2009-03-01 00:00:00

abstract：:Secondary acute lymphoblastic leukemia (s-ALL) is rare and poorly defined and data regarding outcomes post-transplant are lacking. Here, we report a detailed analysis of s-ALL at our Institution. Among 211 eligible patients with ALL from 2006 to 2017, 30 (14%) were defined as s-ALL and the remaining as primary ALL (p-...

journal_title：Leukemia research

authors： Ferraro F,Gao F,Stockerl-Goldstein K,Westervelt P,DiPersio JF,Ghobadi A

更新日期：2018-09-01 00:00:00

abstract：:The hotspot c.7541_7542delCT NOTCH1 mutation has been proven to have a negative clinical impact in chronic lymphocytic leukemia (CLL). However, an optimal method for its detection has not yet been specified. The aim of our study was to examine the presence of the NOTCH1 mutation in CLL using three commonly used molecu...

journal_title：Leukemia research

authors： Vavrova E,Kantorova B,Vonkova B,Kabathova J,Skuhrova-Francova H,Diviskova E,Letocha O,Kotaskova J,Brychtova Y,Doubek M,Mayer J,Pospisilova S

更新日期：2017-09-01 00:00:00

abstract：:We evaluated the efficacy of FISH to detect chromosome anomalies in the evaluation of young (<60 years) patients with AML. Patients were enrolled in E1900, an ECOG clinical trial for AML. The protocol was designed to collect bone marrow or blood for both cytogenetic and FISH studies at study entry (diagnosis). FISH fo...

journal_title：Leukemia research

authors： Vance GH,Kim H,Hicks GA,Cherry AM,Higgins R,Hulshizer RL,Tallman MS,Fernandez HF,Dewald GW

更新日期：2007-05-01 00:00:00