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Functional interleukin-2 receptor on a Tac negative human leukaemia T-cell line.

Abstract：

:Cell line PER-423 was derived from the cells of a patient with an immature acute T-lymphoblastic leukaemia and the growth of this human cell line is strictly dependent on interleukin-2 (IL-2). PER-423 cells express the p75 (beta) subunit of the IL-2 receptor (IL-2R beta), while the p55 chain (IL-2R alpha) is not detectable by immunofluorescence. The analysis of the IL-2R revealed that it is of intermediate affinity and the median effective IL-2 concentration for PER-423 cells (EC50 value) was determined to be 1.44 +/- 0.29 nM. Chemical crosslinking studies showed that the receptor consists of one polypeptide of approximately 95 kDa as well as a doublet of 70 kDa and 60 kDa and does not include the IL-2R alpha-chain. The steady-state mRNA level for the p75 subunit was similar to that present in a cell line expressing an IL-2R alpha+ beta+, while only traces for the alpha-chain were detectable. PER-423 cells can be induced to express the alpha-chain of the IL-2R on the cell surface, concomitant with a much reduced EC50 level. Since cell line PER-423 is functionally dependent on IL-2, it provides an ideal model for IL-2 signal transduction studies and for investigations focusing on the requirements for ligand binding vs activation.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Kees UR,Ford J,Peroni SE,Ranford PR

doi

10.1016/0145-2126(93)90141-7

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

51-9

issue

1

eissn

0145-2126

issn

1873-5835

pii

0145-2126(93)90141-7

journal_volume

17

pub_type

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