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Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia.

Abstract：

:This study focuses on the effect of chemotherapy on endocrinopathies and the metabolic syndrome in adult survivors of childhood acute myeloid leukemia (AML). Endocrine function and metabolic syndrome were evaluated in 12 AML survivors, treated with chemotherapy, and in 9 survivors of myeloid leukemias treated with stem cell transplantation (SCT), after a median follow-up time of 20 years (range 9-31). In survivors treated with chemotherapy, no endocrinopathies or metabolic syndrome were present, although AMH and Inhibin B levels tended to be lower than in controls. In SCT survivors, pituitary deficiencies and metabolic syndrome were more frequent.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Blijdorp K,van Waas M,van der Lely AJ,Pieters R,van den Heuvel-Eibrink M,Neggers S

doi

10.1016/j.leukres.2012.12.008

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

367-71

issue

4

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(12)00479-1

journal_volume

37

pub_type

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