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Loss of heterozygosity and heterogeneity of its appearance and persisting in the course of acute myeloid leukemia and myelodysplastic syndromes.

Abstract：

:Screening for loss of heterozygosity (LOH) of the panel of 18 highly polymorphic microsatellite markers, especially from the region 11p15, was carried out on 154 samples from 26 patients with acute myeloid leukemia and eight with myelodysplastic syndromes (MDS). LOH was detected at the majority (72%) of the loci tested: 47% of informative patients displayed LOH for at least one of the microsatellite locus from the region 11p15 and 23.5% of patients displayed LOH among the other markers tested within the study. A longitudinal follow-up of patients showed a remarkable heterogeneity of LOH appearance and its persistance during the course of the disease suggesting an intratumor clonal heterogeneity, or alternatively, presence of LOH in more than one cell clone. The data revealed two regions of high loss of one allele in 11p15.5, defined by markers D11S1363 and D11S1338, indicating that LOH at the subtelomeric region of the short arm of chromosome 11 is a much common event in hematological malignancies than it was previously reported.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Krsková-Honzátková L,Cermák J,Sajdová J,Starý J,Sedlácek P,Sieglová Z

doi

10.1016/s0145-2126(00)00086-2

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

45-53

issue

1

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(00)00086-2

journal_volume

25

pub_type

杂志文章

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