High Th1/Th2 ratio in patients with multiple myeloma.

abstract：:We investigated the transcript levels of genes STAT1, STAT3, STAT5A and STAT5B in the diagnostic samples of childhood ALL patients and compared them to those of healthy controls in order to characterize STAT gene expression in childhood ALL. As compared to controls, ALL patients exhibit markedly decreased transcript l...

journal_title：Leukemia research

authors： Adamaki M,Tsotra M,Vlahopoulos S,Zampogiannis A,Papavassiliou AG,Moschovi M

更新日期：2015-09-11 00:00:00

abstract：:We compared the growth-inhibitory effects and inhibition profile of the SRC family kinases (SFKs) of imatinib, dasatinib, nilotinib and INNO-406. Dasatinib exhibited the strongest potency against BCR-ABL with little selectivity over SFKs. Nilotinib exhibited a weaker affinity than the other inhibitors, but was highly ...

journal_title：Leukemia research

authors： Deguchi Y,Kimura S,Ashihara E,Niwa T,Hodohara K,Fujiyama Y,Maekawa T

更新日期：2008-06-01 00:00:00

abstract：:Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxicity in human acute promyelocytic leukemia NB4 cells by early disturbance in mitochondrial function and oxidative stres...

journal_title：Leukemia research

authors： García-Pérez AI,Galeano E,Nieto E,Estañ MC,Sancho P

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Current results regarding treatment outcomes in acute myeloid leukemia (AML) point to significant differences between low- and middle-income countries (LMIC) and high-income countries (HIC). Excluding well-known socioeconomic issues, genetic markers important for prognosis have not been properly incorporated...

journal_title：Leukemia research

authors： Benicio MTL,Ribeiro AFT,Américo AD,Furtado FM,Glória AB,Lima AS,Santos SM,Xavier SG,Lucena-Araujo AR,Fagundes EM,Rego EM

更新日期：2017-09-01 00:00:00

abstract：:GNAS1 gene is located at the long arm of chromosome 20 (q13.32). GNAS1 gene deletion has never been investigated in MDS. A GNAS1 activating mutation (R201) was recently found in MDS. We applied FISH and DHPLC plus sequencing to investigate GNAS1 gene in MDS cases with and without del(20q) at karyotype. ...

journal_title：Leukemia research

authors： Di Giacomo D,Lema Fernandez AG,Pierini T,Crescenzi B,Brandimarte L,Matteucci C,Testoni N,Mecucci C

更新日期：2014-07-01 00:00:00

abstract：:The peripheral blood lymphocyte to monocyte ratio (LMR) at diagnosis has been used to predict survival in diffuse large B-cell lymphoma (DLBCL) patients, but its prognostic significance with respect to different cell-of-origin (COO) subtypes remains unknown. We retrospectively analyzed 168 de novo DLBCL patients in th...

journal_title：Leukemia research

authors： Wei X,Huang F,Wei Y,Jing H,Xie M,Hao X,Feng R

更新日期：2014-06-01 00:00:00

abstract：:CFW/D mice injected neonatally with a type B retrovirus, (DMBA-LV), rapidly develop thymic lymphomas. The present study examined simultaneously the karyotype and the expression of surface antigens on thymocytes from DMBA-LV treated mice at 28, 35 and 42 days of age during the development of lymphomas, and of cells fro...

journal_title：Leukemia research

authors： Mueller RE,Ball JK,Chan FP

更新日期：1989-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is rare in Asians living in Asia and possibly in US Asians. In contrast, CLL is the most common leukemia in whites. The basis for this ethnic and geographic variation is unknown. We compared average annual age-adjusted incidence rates (AAIR) of CLL diagnosed from 1972 to 1995 among L...

journal_title：Leukemia research

authors： Gale RP,Cozen W,Goodman MT,Wang FF,Bernstein L

更新日期：2000-08-01 00:00:00

abstract：:Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p<0.001) and do...

journal_title：Leukemia research

authors： Lönnerholm G,Thörn I,Sundström C,Frost BM,Abrahamsson J,Behrendtz M,Heldrup J,Jacobsson S,Li A,Olofsson T,Porwit A,Söderhäll S,Larsson R,Forestier E

更新日期：2009-01-01 00:00:00

abstract：:Despite the evolution of effective frontline treatment strategies, many patients with myeloma inevitably relapse. Treatment can be complicated by the interplay of disease-, treatment-, and patient-related factors. Unfortunately, many patients eventually develop disease that is refractory to lenalidomide and bortezomib...

journal_title：Leukemia research

authors： Mark TM,Coleman M,Niesvizky R

更新日期：2014-05-01 00:00:00

abstract：:Compound 48 (C48) is a novel dual ligand for peroxisome proliferator-activated receptor alpha and gamma (PPAR alpha/gamma). Culture of imatinib-sensitive and -resistant CML cell lines with C48 resulted in a strong growth inhibition which associated with G0/G1 cell cycle arrest. However, it showed no obvious toxicity t...

journal_title：Leukemia research

authors： Bertz J,Zang C,Liu H,Wächter M,Possinger K,Koeffler HP,Elstner E

更新日期：2009-05-01 00:00:00

abstract：:The Philadelphia (Ph1) chromosome is a specific structural abnormality in which the abl oncogene is activated due to the formation of the novel chimeric gene, bcr/abl. To investigate the clinicopathological role of bcr/abl in Ph1-positive chronic myelogenous leukaemia (CML), we studied the clonal origin of haematopoie...

journal_title：Leukemia research

authors： Sadamura S,Umemura T,Takahira H,Hirata J,Nishimura J,Nawata H

更新日期：1992-01-01 00:00:00

abstract：:Smoking may be associated with accelerated erythropoiesis, leukocytosis and thrombocytosis, which are also hallmarks in patients with polycythemia vera, essential thrombocythemia and early stages of myelofibrosis (MPNs). The JAK-STAT and NF-κB signaling pathways are activated in both smokers and in patients with MPNs....

journal_title：Leukemia research

authors： Hasselbalch HC

更新日期：2015-09-09 00:00:00

abstract：:Septins are proteins associated with crucial steps in cell division and cellular integrity. In humans, 14 septin genes have been identified, of which five (SEPT2, SEPT5, SEPT6, SEPT9, and SEPT11) are known to participate in reciprocal translocations with the MLL gene in myeloid neoplasias. We have recently shown a sig...

journal_title：Leukemia research

authors： Santos J,Cerveira N,Bizarro S,Ribeiro FR,Correia C,Torres L,Lisboa S,Vieira J,Mariz JM,Norton L,Snijder S,Mellink CH,Buijs A,Shih LY,Strehl S,Micci F,Heim S,Teixeira MR

更新日期：2010-05-01 00:00:00

abstract：:The simultaneous occurrence of two specific acquired chromosomal abnormalities in chronic or acute leukaemias is rare. Inherited chromosomal abnormalities are also rare events in the general population. In chronic myeloid leukaemia (CML), characterised by the t(9;22)(q34;q11), the inv(16)(p13q22) has been described as...

journal_title：Leukemia research

authors： Silva PM,Lourenço GJ,Bognone RA,Delamain MT,Pinto-Junior W,Lima CS

更新日期：2006-01-01 00:00:00

abstract：:Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. We report here that OPN gene is transactivated by Tax protein of human T-cell leukemia virus type 1 (HTLV-1). Northern blot showed enhanced OPN gene expression in cells stably expressing Tax....

journal_title：Leukemia research

authors： Zhang J,Yamada O,Matsushita Y,Chagan-Yasutan H,Hattori T

更新日期：2010-06-01 00:00:00

abstract：:Feulgen-DNA cytophotometry and 3H-thymidine autoradiography were used to evaluate therapeutic cytapheresis effects on cell cycle distributions of peripheral blood leukemic cells in 15 acute leukemia, 5 CML and 8 CLL patients and of bone marrow erythroblasts in 18 PV patients. Both individual cytapheresis procedures an...

journal_title：Leukemia research

authors： Kotelnikov VM,Kasatkina VV,Dultsina SM,Sarytcheva TG,Kalinin NN,Kovaleva LG,Poljanskaja AM,Isajev VG,Khoroshko ND,Lishmanova NG

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...

journal_title：Leukemia research

authors： He H,Fu W,Jiang H,Du J,Zhou L,Zhang C,Xi H,Li R,Hou J

更新日期：2015-05-01 00:00:00

abstract：:The expression of various proto-oncogenes in primary culture of lymphocytes from peripheral blood of bovine with chronic lymphocytic leukemia (CLL) was studied. Cellular proto-oncogenes encode proteins that propagate growth, differentiation or apoptosis signals from cell membrane to nucleus. The proliferation and diff...

journal_title：Leukemia research

authors： Kalvelyte AV,Pabrezaite LC

更新日期：1998-02-01 00:00:00

abstract：:We studied 98 female patients in remission (2-240 months) from childhood ALL to determine the clonality status of their hematopoiesis. Thirty-one (31.6%) were heterozygous at the PGK locus for the BstX1 endonuclease restriction site, permitting X-linked clonality assays to be performed. Two patients were in relapse at...

journal_title：Leukemia research

authors： Busque L,Ilaria R Jr,Tantravahi R,Weinstein H,Gilliland DG

更新日期：1994-02-01 00:00:00

abstract：:Mutations in Janus kinase 2 (JAK2) are implicated in the pathogenesis of Philadelphia-chromosome negative myeloproliferative neoplasms, including primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2V61...

journal_title：Leukemia research

authors： Verstovsek S,Mesa RA,Salama ME,Li L,Pitou C,Nunes FP,Price GL,Giles JL,D'Souza DN,Walgren RA,Prchal JT

更新日期：2017-10-01 00:00:00

abstract：:Hyperdiploid and non-hyperdiploid multiple myeloma represents distinct biological entities characterized by different patterns of genetic changes. We sought to determine whether ploidy category (non-hyperdiploid versus hyperdiploid) remains stable over time from diagnosis to progression. Of the 43 patients studied (39...

journal_title：Leukemia research

authors： Chng WJ,Winkler JM,Greipp PR,Jalal SM,Bergsagel PL,Chesi M,Trendle MC,Ahmann GJ,Henderson K,Blood E,Oken MM,Hulbert A,Van Wier SA,Santana-Dávila R,Kyle RA,Gertz MA,Lacy MQ,Dispenzieri A,Fonseca R

更新日期：2006-03-01 00:00:00

abstract：:Normal human peripheral blood polymorphonuclear leukocytes (PMNs) and cells from a human acute promyelocytic leukemia line (HL-60) were tested for cytotoxic potential against two human glioma and one normal fibroblast line. Both the PMNs and HL-60 exhibited significant cytotoxicity against the tumor targets while spar...

journal_title：Leukemia research

authors： Buessow SC,Gillespie GY,Mahaley MS

更新日期：1984-01-01 00:00:00

abstract：:Little information is available about the risk factors and means to improve the survival rate of acute leukemia in a rare but often fatal complication after liver transplantation (LT). We report the development of AML-M2 in one of the 764 patients who underwent liver transplantation at our center, and review the liter...

journal_title：Leukemia research

authors： Jiang N,Li H,Wang GS,Zhang J,Zhang JF,Yi SH,Yang Y,Cai CJ,Lu MQ,Chen GH

更新日期：2009-10-01 00:00:00

abstract：:In a recent phase I study, a combination of gemcitabine at 10 mg/(m(2)min) for 12 h and mitoxantrone 12 mg/m(2) daily for 3 days, achieved a complete remission (CR) in 3 of 12 (25%) patients with refractory leukemia. A pilot assessment of this regimen was conducted to determine its tolerability in patients with refrac...

journal_title：Leukemia research

authors： Apostolidou E,Estey E,Cortes J,Garcia-Manero G,Faderl S,Thomas D,Tsimberidou A,Kantarjian H,Giles FJ

更新日期：2003-04-01 00:00:00

abstract：:FLT3 is a receptor tyrosine kinase involved in the survival of hematopoietic stem cells, and mutations of FLT3 have been reported to be of prognostic significance. This is the first study of FLT3 mutations in pediatric non-promyelocytic AML patients that received the same treatment scheme in single institute. FLT3 int...

journal_title：Leukemia research

authors： Kang HJ,Hong SH,Kim IH,Park BK,Han KS,Cho HI,Shin HY,Ahn HS

更新日期：2005-06-01 00:00:00

abstract：:Rearrangements in MLL (MLL-r) are common within very young children with leukemia and affect the prognosis and treatment. Previous studies have suggested the use of the NG2 molecule as a marker for MLL-r but these studies were performed using a small number of infants. We analyzed 148 patients (all less than 24 months...

journal_title：Leukemia research

authors： Emerenciano M,Renaud G,Sant'Ana M,Barbieri C,Passetti F,Pombo-de-Oliveira MS,Brazilian Collaborative Study Group of Infant Acute Leukemia.

更新日期：2011-08-01 00:00:00

abstract：:Although abnormalities in granulopoiesis detected by means of bone marrow cytology, culture and kinetic studies have provided prognostic data in preleukemic states and oligoblastic leukemias, this information cannot be applied to individual cases. In order to determine the indications for treatment and the form it sho...

journal_title：Leukemia research

authors： Karsdorf A,Dresch C,Metral J,Najean Y

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are associated with increases in janus kinase 2 (JAK2) signaling, often resulting from the JAK2 V617F mutation. LY2784544 (gandotinib) is a potent, selective, small-molecule inhibitor of JAK2 that has potential dose-dependent selectivit...

journal_title：Leukemia research

authors： Berdeja J,Palandri F,Baer MR,Quick D,Kiladjian JJ,Martinelli G,Verma A,Hamid O,Walgren R,Pitou C,Li PL,Gerds AT

更新日期：2018-08-01 00:00:00

abstract：:The monoclonal antibody AGF2.3 identifies a nuclear envelope protein expressed at high levels in most transformed cell lines and weakly expressed in or absent from normal tissues and primary cell cultures. Here we report that expression of AGF2.3 antigen relates to the maturation status of cells. When HL60 cells were ...

journal_title：Leukemia research

authors： Brown G,Bunce CM,Johnson GD,Lord JM

更新日期：1986-01-01 00:00:00