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Clinical relevance of hypogammaglobulinemia, clinical and biologic variables on the infection risk and outcome of patients with stage A chronic lymphocytic leukemia.

Abstract：

:The prognostic effect of hypogammaglobulinemia (HGG), clinical and biologic characteristics on the infection risk and outcome has been retrospectively analyzed in 899 patients with stage A chronic lymphocytic leukemia (CLL). Low levels of IgG were recorded in 19.9% of patients at presentation, low levels of IgM and/or IgA in 10.4% and an additional 20% of patients developed HGG during the course of the disease. Before the start of any treatment, 160 (12.9%) patients experienced at least one grade ≥3 infection requiring a systemic anti-infective treatment and/or hospitalization. While IgG levels at diagnosis were not associated with an increased risk of grade ≥3 infection or with an adverse outcome, a significantly increased rate of grade ≥3 infections was recorded in patients with unmutated IGHV (p=0.011) and unfavorable FISH aberrations (p=0.009). Late onset HGG, more frequently recorded in patients with Rai stage I-II (p=0.001) and unmutated IGHV (p=0.001), was also associated with a higher rate of severe infections (p=0.002). These data indicate that, stage A patients with clinical and biologic characteristics of a more aggressive disease develop more frequently late onset HGG, grade ≥3 infections and require a closer clinical monitoring.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Mauro FR,Morabito F,Vincelli ID,Petrucci L,Campanelli M,Salaroli A,Uccello G,Petrungaro A,Ronco F,Raponi S,Nanni M,Neri A,Ferrarini M,Guarini AR,Foà R,Gentile M

doi

10.1016/j.leukres.2017.02.011

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

65-71

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(17)30067-X

journal_volume

57

pub_type

杂志文章

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