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Imatinib mesylate (IM)-induced growth inhibition is associated with production of spliced osteocalcin-mRNA in cell lines.

Abstract：

:It has been suggested that imatinib mesylate (IM) influences osteogenesis and bone turnover in treated patients. Here we show that the inhibitory effect of IM on cell multiplication is associated with an increased proportion of spliced osteocalcin (OCNs) in leukemia (HL-60) and osteosarcoma cells (MG-63, U-2 OS), despite a lower mRNA synthesis rate. In mouse osteoblastic MC3T3-E1 cells only OCNs is present, independently of treatment. As the stimulatory effect of IM on OCNs is also observed upon treatment with vitamin D, common regulatory processes may be considered.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Wihlidal P,Karlic H,Pfeilstöcker M,Klaushofer K,Varga F

doi

10.1016/j.leukres.2007.07.020

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

437-43

issue

3

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(07)00300-1

journal_volume

32

pub_type

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