Abstract:
BACKGROUND:The significance of persistent or recurrent respiratory infections in adult life for the development of chronic obstructive pulmonary disease (COPD) is still to a large extent unknown. A few clinical and experimental animal studies suggest that peripheral airways diseases may be due to the cumulative effects of recurrent respiratory infections over an extended period. METHODS:C. pneumoniae-specific IgG and IgA antibody levels were determined in two elderly groups of male patients with COPD and in control subjects without the disease. The first group (N = 36) consisted of patients who were hospitalized due to an acute exacerbation of COPD. The second group of patients (N = 54) and the controls (N = 321) were participants in a community survey on respiratory diseases in the elderly. The criteria for seropositivity were defined as an IgG titre of >=16. RESULTS:89% of the hospitalized patients (group I) and 66% of the non-hospitalized patients (Group II) were IgA seropositive as compared to 55% of the controls. Derived from the logistic regression analysis, the odds ratio (OR) WAS 7.4 (95% CI : 2.1-25.7) between group I and the controls and 1.5 (0.7-2.9) between group II and controls. Furthermore, the difference in the age-adjusted geometric mean titres (GMT) of lgA antibodies between the group I and the controls was significant (53.0 for the patients versus 19.1 for the controls). On the contrary, no significant differences between the patients and the controls were found either in the proportion of IgG-seropositive or in the GMT of IgG antibodies. Two of the 29 patients with an exacerbation of COPD, for whom paired sera were available, showed an antibody response suggesting a current acute or reactivated chlamydial infection. CONCLUSIONS:The results showed that C. pneumoniae lgA antibodies are found more frequently and in higher concentrations in COPD patients than in disease-free controls. The finding may indicate a chronic C. pneumoniae infection in these patients. The association persisted after controlling for the potential confounding effect of smoking.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
von Hertzen L,Isoaho R,Leinonen M,Koskinen R,Laippala P,Töyrylä M,Kivelä SL,Saikku Pdoi
10.1093/ije/25.3.658subject
Has Abstractpub_date
1996-06-01 00:00:00pages
658-64issue
3eissn
0300-5771issn
1464-3685journal_volume
25pub_type
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