Specificity of association in analysis of mortality and inference on causality.

Abstract:

:Specificity of association between putative risk factor and disease under study is important to inference on causality. Nevertheless many studies investigate mortality of a single disease without comparison with a control. Age-standardized proportional mortality ratios make single disease studies into case-control studies and thus demonstrate whether or not associations are disease specific. Comparison of disease-specific with all-cause mortality experiences of whole populations classified by exposure, clearly distinguishes between exposures associated with more death and with earlier/younger death, thereby overcoming an important limitation of the familiar standardized mortality ratio (SMR). Smoking is associated with more death from lung cancer (lifetime cause-specific proportions, never 1%, light 6%, moderate 8% and heavy 12%) and with earlier/younger death from ischaemic heart disease (never 35%, light 34%, moderate 32% and heavy 29%).

journal_name

Int J Epidemiol

authors

West RR

doi

10.1093/ije/20.4.984

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

984-8

issue

4

eissn

0300-5771

issn

1464-3685

journal_volume

20

pub_type

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