Abstract：
BACKGROUND:During pregnancy, woman and fetus exchange small quantities of cells, and their persistence at later times is termed microchimerism. Microchimerism is known to substantially impact on women's later health. This study examined the survival of women according to male microchimerism status. METHODS:Male microchimerism presence, measured as Y chromosome in peripheral blood samples, was determined in 272 women from the large Danish Diet, Cancer and Health cohort when aged 50-64 years during 1993-97. Women were followed up for cause-specific death in national Danish registers until the end of 2009. Survival was analysed using Cox regression. RESULTS:A total of 190 women (70%) were male microchimerism positive. During follow-up 21 women died, of whom 11 (52%) were male microchimerism positive at enrolment and 10 were negative. Of the 21 deaths, 13 (62%) were due to cancer and 5 (24%) were due to cardiovascular disease. Male microchimerism presence was associated with a reduced hazard ratio of all-cause mortality of 0.42 (95% CI 0.17-1.03). The hazard ratio of death from cancer and cardiovascular disease was 0.24 (95% CI 0.08-0.79) and 1.66 (95% CI 0.18-15.48), respectively, among male microchimerism positive compared with negative women. CONCLUSIONS:Although the biological mechanisms are not precisely known, male microchimerism presence in peripheral blood of women is associated with substantially improved survival in women. The results also indicate that the association with male microchimerism may vary between different causes of death.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Kamper-Jørgensen M,Hjalgrim H,Andersen AM,Gadi VK,Tjønneland Adoi
10.1093/ije/dyt230subject
Has Abstractpub_date
2014-02-01 00:00:00pages
168-73issue
1eissn
0300-5771issn
1464-3685pii
dyt230journal_volume
43pub_type
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