Abstract:
BACKGROUND:It is unclear when in the life course do social inequalities in inflammation emerge. We examined whether the association between socioeconomic position (SEP) and C-reactive protein (CRP) is determined at conception, in childhood, adolescence or adulthood in 1484 participants from the population-based Cardiovascular Risk in Young Finns Study.
METHODS:Five variants of the CRP gene were used to investigate whether SEP differences in CRP levels are determined at conception. SEP and serum CRP were assessed in childhood (age 3-9), adolescence (age 12-18) and in adulthood (age 24-39). SEP was measured using parental education and occupational status in childhood and adolescence, and participants' own education and occupational status in adulthood. Participants with CRP > 10 mg/l were excluded.
RESULTS:All CRP gene variants were associated with circulating CRP concentrations in childhood, but there were no differences in the distribution of these variants by SEP. No strong evidence was found of associations between parental SEP and CRP. A graded association between higher SEP and lower CRP was observed in adulthood for education (P = 0.0005) but not for occupational status. Trajectories that led to high educational achievement both in the participants and their parents were associated with lower (P journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
abstract::Data from the Seven Countries Study are analysed to examine the relationship between the observed incidence of Coronary Heart Disease in the second 5-year period of follow-up and the major entry risk factors and their changes over the first 5 years. The analysis, using the Multiple Logistic Function model, shows that ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/10.1.31
更新日期:1981-03-01 00:00:00
abstract::A generalized least squares regression approach is proposed for the analysis of data arising from experimental studies involving cluster randomization and non-experimental studies in which the major treatment factor corresponds to a characteristic which applies at the cluster level. This approach is more flexible than...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.2.322
更新日期:1985-06-01 00:00:00
abstract::A multidisciplinary approach to research has been one of the hallmarks of Walter Holland's outstanding career in medical research. Studies arising from evaluation of the Cancer Research Campaign's health education programme for the early detection of cutaneous malignant melanoma were reviewed at Walter's Festschrift b...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.supplement_1.s39
更新日期:1995-01-01 00:00:00
abstract::We undertook a case-control study to investigate the association between chemicals in maternal drinking water consumed during pregnancy and congenital heart disease in the offspring. Two hundred and seventy affected children and 665 healthy children were enrolled in the study. Information on contaminant levels in mate...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.3.589
更新日期:1988-09-01 00:00:00
abstract::The Rochester Epidemiology Project (REP) medical records-linkage system was established in 1966 to capture health care information for the entire population of Olmsted County, MN, USA. The REP includes a dynamic cohort of 502 820 unique individuals who resided in Olmsted County at some point between 1966 and 2010, and...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys195
更新日期:2012-12-01 00:00:00
abstract::The European Prospective Investigation of Cancer (EPIC) is a 10-country collaborative study in which EPIC-Norfolk is one of the UK centres. EPIC-Norfolk examined 25 639 men and women resident in East Anglia (aged 40-79 years), between 1993 and 1997. The EPIC collaboration was set up to examine the dietary determinants...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt086
更新日期:2014-08-01 00:00:00
abstract::There has been a general decline in mortality from ischaemic heart disease (IHD) in Finland since the beginning of the 1970s. An intensified preventive programme was started in the province of North Karelia in 1972. Between 1974 and 1979 the decline in IHD mortality in North Karelian men was steeper than that in the r...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:Background:Maternal short stature has been observed to increase the risk of preterm birth; however, the aetiology behind this phenomenon is unknown. We investigated whether preeclampsia, an obstetric complication that often leads to preterm delivery and is reported to have an inverse association with women's height, me...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/dyx107
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Perception of control over one's environment, particularly when faced with an ambiguous situation, has been identified as a critical cognitive process involved in worry and generalized anxiety disorder (GAD). Similarly, it is thought that individuals with lower cognitive skills feel less in control, and do n...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dym063
更新日期:2007-08-01 00:00:00
abstract::Cirrhosis mortality death rates in Ontario for ages 20 and over declined from a high of 9.3 per 100,000 in 1911 to a low of 5.6 per 100,000 in 1919 (p less than 0.001) and after a 17-year period of relative stability, rose steadily to a high of 19.7 per 100,000 in 1975 (p less than 0.0001) and then declined to 13.3 pe...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.1.199
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Most HIV infections originate from individuals who are undiagnosed and unaware of their infection. Estimation of this quantity from surveillance data is hard because there is incomplete knowledge about (i) the time between infection and diagnosis (TI) for the general population, and (ii) the time between imm...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyz100
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:To examine educational gradients in overall and cause-specific mortality among elderly married men and women and their spouses. METHODS:Using the census-based Israel Longitudinal Mortality Study (1983-92), 13 573 married men and 6563 married women were identified who were aged 70-89 years at baseline. Cox p...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyi185
更新日期:2005-12-01 00:00:00
abstract:Background:It is known that perchlorate, nitrate and thiocyanate have the property of inhibiting sodium iodide symporter. Animal studies have suggested that these compounds, especially perchlorate, might also interfere with insulin secretion. However, the association between their exposure and diabetes risk is largely ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx188
更新日期:2017-12-01 00:00:00
abstract::Birth-cohort analysis is of particular importance for gastric cancer since migrant studies have indicated that early life experiences play a dominant role in the occurrence of the disease. However, none of the birth-cohort analyses conducted in various countries have provided information on variation in the birth-coho...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.2.252
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:The incidence of hepatitis C (HCV) infection among injecting drug users (IDUs) in Dublin is particularly high by international standards. The most robust predictor of an IDU's HCV status is his or her total number of lifetime injecting episodes. It has been proposed that participation in specific unsafe inje...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh347
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Increases in measles antibodies without rash-illnesses have been documented in previously vaccinated children exposed to measles cases. The phenomenon has been incompletely evaluated in young unvaccinated infants with immunity of maternal origin. METHODS:Monthly cohorts of newborns were prospectively random...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ije/28.1.147
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Infant mortality rates vary substantially among municipalities in the State of Ceará, from 14 to 193 per 1000 live births. Identification of the determinants of these differences can be of particular importance to infant health policy and programmes in Brazil where local governments play a pivotal role in pr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/28.2.267
更新日期:1999-04-01 00:00:00
abstract::The reliability of casual blood pressures for reflecting blood pressure status and predicting cardiovascular sequelae of hypertension was examined in the Framingham cohort of 5209 men and women followed for 18 years. Blood pressures were more variable in persons with higher levels. After controlling for pressure level...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/5.4.327
更新日期:1976-12-01 00:00:00
abstract::A matched case-control study among cervical cancer patients in Denmark was conducted to evaluate the possible influence of radiation therapy on leukaemia risk. Among 25718 women treated between 1943-1977, 27 cases of leukaemia occurred one or more years after diagnosis. Four controls were matched to each case on age, ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.3.363
更新日期:1985-09-01 00:00:00
abstract::Mortalities from selected causes from 1973 to 1982 among Koreans, Chinese, and Americans residing in Japan were compared with those of Japanese. In the Korean population, besides the well-documented excess in mortalities from liver cancer, lung cancer, liver cirrhosis and male tuberculosis, a rather prominent elevatio...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.3.415
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Endometriosis has been associated with a higher risk of cutaneous melanoma, but the mechanisms underlying this association are unknown.Some constitutional factors known to influence melanoma risk have been associated with endometriosis in some retrospective studies. However, prospective data are scarce, and ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt235
更新日期:2014-02-01 00:00:00
abstract::The distribution of death certification rates from various cancers or groups of cancers in broad Italian geographical areas (north/centre/south) was analysed. In both sexes, total cancer mortality was considerably elevated in the north of the country compared to southern regions (around 70% for males and 30% for femal...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.4.538
更新日期:1985-12-01 00:00:00
abstract::In recent years a strong case has been made in support of a viral aetiology for at least some primary hepatocellular carcinoma (PHC) in areas of low incidence. By pooling routinely collected cancer registration and infection data, study of the relationship between hepatitis B virus (HBV) infection and the incidence of...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.1.60
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:The role of trigger factors in acute cardiovascular events has been much studied in the past few years. A recent study analysed changes in the rates of cardiac emergencies in Bavaria (Germany) during the last Football World Cup. The authors reported a 2.7-fold increase in the incidence of cardiac emergencies...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyq007
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Sub-Saharan Africa (SSA) has the highest burden of HIV in the world and a rising prevalence of cardiometabolic disease; however, the interrelationship between HIV, antiretroviral therapy (ART) and cardiometabolic traits is not well described in SSA populations. METHODS:We conducted a systematic review and m...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyt198
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The majority of tuberculosis (TB) cases in low-incidence countries occur in migrants. Only few studies have assessed the long-term TB risk in migrants after immigration, and datasets have not considered this across a range of diverse migrant groups. This nationwide study aimed to investigate long-term TB ris...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa063
更新日期:2020-06-01 00:00:00
abstract::In the Hérault region of France, vineyards cover an area of 128,000 hectares (60% of agricultural land) and involve more than 93% of farms. A vine-growing exposure matrix was built for assessing pesticide exposure. It is based on information obtained from a survey among 85 vine-growers who lived in Hérault and who had...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.supplement_2.s36
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Identifying mild cognitive impairment (MCI) in midlife could improve early identification of Alzheimer's disease (AD). Also, AD is highly heritable, but the heritability of MCI has not been established. We estimated prevalence rates, association with premorbid general cognitive ability (GCA) and heritability...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt242
更新日期:2014-04-01 00:00:00
abstract:BACKGOUND:The term 'joint modelling' is used in the statistical literature to refer to methods for simultaneously analysing longitudinal measurement outcomes, also called repeated measurement data, and time-to-event outcomes, also called survival data. A typical example from nephrology is a study in which the data from...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/dyu262
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Two recent much cited publications have raised the concern that risk associated with cigarette smoking has so far been underestimated. In this study we wish to determine whether excess all-cause mortality associated with smoking has increased during the last 20-30 years in a study population representative o...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.6.1214
更新日期:1997-12-01 00:00:00