Abstract:
BACKGROUND:Most HIV infections originate from individuals who are undiagnosed and unaware of their infection. Estimation of this quantity from surveillance data is hard because there is incomplete knowledge about (i) the time between infection and diagnosis (TI) for the general population, and (ii) the time between immigration and diagnosis for foreign-born persons. METHODS:We developed a new statistical method for estimating the incidence of HIV-1 and the number of undiagnosed people living with HIV (PLHIV), based on dynamic modelling of heterogeneous HIV-1 surveillance data. The methods consist of a Bayesian non-linear mixed effects model using multiple biomarkers to estimate TI of HIV-1-positive individuals, and a novel incidence estimator which distinguishes between endogenous and exogenous infections by modelling explicitly the probability that a foreign-born person was infected either before or after immigration. The incidence estimator allows for direct calculation of the number of undiagnosed persons. The new methodology is illustrated combining heterogeneous surveillance data from Sweden between 2003 and 2015. RESULTS:A leave-one-out cross-validation study showed that the multiple-biomarker model was more accurate than single biomarkers (mean absolute error 1.01 vs ≥1.95). We estimate that 816 [95% credible interval (CI) 775-865] PLHIV were undiagnosed in 2015, representing a proportion of 10.8% (95% CI 10.3-11.4%) of all PLHIV. CONCLUSIONS:The proposed methodology will enhance the utility of standard surveillance data streams and will be useful to monitor progress towards and compliance with the 90-90-90 UNAIDS target.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Giardina F,Romero-Severson EO,Axelsson M,Svedhem V,Leitner T,Britton T,Albert Jdoi
10.1093/ije/dyz100subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1795-1803issue
6eissn
0300-5771issn
1464-3685pii
5487755journal_volume
48pub_type
杂志文章abstract::Social inequities and their relation to health form a topic of growing concern in the Netherlands. The present investigation on educational level and mortality was carried out in a cohort of men born in 1932, examined for military service in 1950/1951 and for whom vital statistics could be obtained. In the group of 78...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.2.374
更新日期:1990-06-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.2.259
更新日期:1996-04-01 00:00:00
abstract::Mortalities from selected causes from 1973 to 1982 among Koreans, Chinese, and Americans residing in Japan were compared with those of Japanese. In the Korean population, besides the well-documented excess in mortalities from liver cancer, lung cancer, liver cirrhosis and male tuberculosis, a rather prominent elevatio...
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更新日期:1987-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-06-01 00:00:00
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更新日期:1978-03-01 00:00:00
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