Abstract:
:A matched case-control study among cervical cancer patients in Denmark was conducted to evaluate the possible influence of radiation therapy on leukaemia risk. Among 25718 women treated between 1943-1977, 27 cases of leukaemia occurred one or more years after diagnosis. Four controls were matched to each case on age, calendar year of diagnosis and survival without developing a second cancer. Detailed medical records were abstracted, and individual radiation doses to active bone marrow were determined by medical physicists. All leukaemia diagnoses were classified by one haematopathologist. A 2.5-fold risk of radiogenic leukaemia was found, although the excess was not statistically significant (95% Cl = 0.5-12.1). The pattern of risk by dose was somewhat compatible with animal experiments, ie, the risk rose, peaked, and then decreased to near normal levels at the highest dose categories. The average dose to the total bone marrow was 783 rads, and thus a much greater risk of leukaemia was predicted on the basis of estimates from other exposed populations. Assuming that the pelvic bone marrow is essentially destroyed by high-dose radiotherapy and should, perhaps, be disregarded for the purpose of risk estimation, risk coefficients consistent with other studies can be computed. Nonetheless, the very low risk of radiogenic leukaemia found among cervical cancer patients suggests that the induction of leukaemia by radiation is a complex function of dose, and that very high doses may result in a decreased risk, possibly associated with cellular sterilization or other mechanisms.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Storm HH,Boice JD Jrdoi
10.1093/ije/14.3.363subject
Has Abstractpub_date
1985-09-01 00:00:00pages
363-8issue
3eissn
0300-5771issn
1464-3685journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Previous studies on the association between childhood infections and childhood leukaemia have produced inconsistent results, likely due to the recall error/bias of infection data reported by the parents. The current study used a population-based and record-based case-control design to evaluate the associatio...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys113
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Results from some retrospective studies suggest a possible increased risk of glioma and acoustic neuroma in users of mobile phones. METHODS:The relation between mobile phone use and incidence of intracranial central nervous system (CNS) tumours and other cancers was examined in 791,710 middle-aged women in ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt072
更新日期:2013-06-01 00:00:00
abstract:Background:This paper investigates trends in suicide rate, the reasons for and means of suicide and the occupation of deceased, to prioritize suicide prevention activities in India and to highlight the limitations to data quality for surveillance. Methods:Data available in the public domain from the National Crimes Re...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyw113
更新日期:2017-06-01 00:00:00
abstract::Mortality among male employees was studied in a chromium chemical production plant, part of which was rebuilt in 1950-51 and the remainder in 1960, to reduce exposure to chromium bearing dusts. Of 2 101 employees initially employed between 1945 and 1974 and having worked at least 90 days, the vital status of 88% was a...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/8.4.365
更新日期:1979-12-01 00:00:00
abstract::Cirrhosis mortality death rates in Ontario for ages 20 and over declined from a high of 9.3 per 100,000 in 1911 to a low of 5.6 per 100,000 in 1919 (p less than 0.001) and after a 17-year period of relative stability, rose steadily to a high of 19.7 per 100,000 in 1975 (p less than 0.0001) and then declined to 13.3 pe...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.1.199
更新日期:1991-03-01 00:00:00
abstract::A study was made in five rural districts of Kwara State, Nigeria to assess the possible use of 'leopard skin' (Ls) as a rapid diagnostic technique for estimating the endemicity of African onchocerciasis. The findings revealed that there is a positive association between the percentage of subjects with skin microfilari...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.4.590
更新日期:1987-12-01 00:00:00
abstract:Background:The Obstetrics and Periodontal Therapy (OPT) study, a randomized controlled trial, reported no effect of periodontal treatment on preterm birth. Even though there were more spontaneous abortions or stillbirths in the control group, sensitivity analyses using conventional approaches did not change the results...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyy089
更新日期:2018-10-01 00:00:00
abstract::This article takes up the history of North American psychiatric epidemiology with reference to production of knowledge concerning sociopathic or antisocial personality disorder and drug dependence, abuse, and/or addiction. These overlapping arenas provide a microcosm within which to explore the larger shift of postwar...
journal_title:International journal of epidemiology
pub_type: 传,历史文章,杂志文章
doi:10.1093/ije/dyt223
更新日期:2014-08-01 00:00:00
abstract::The 'Mendelian randomization' approach uses genotype as an instrumental variable to distinguish between causal and non-causal explanations of biomarker-disease associations. Classical methods for instrumental variable analysis are limited to linear or probit models without latent variables or missing data, rely on asy...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyp397
更新日期:2010-06-01 00:00:00
abstract::This paper examines methods for estimating the efficiency of measles and pertussis notification with particular reference to England and Wales. Crude estimates are obtained from a comparison of annual numbers of births and notifications, and this approach is modified to include detailed age-specific data. Other source...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.1.153
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:Anxiety or depression symptoms may increase the risk of developing asthma, and their interaction with obesity is not known. We aimed to assess the association of anxiety or depression symptoms and the joint association of these symptoms and obesity with incident asthma. METHODS:We conducted a prospective co...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt151
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:This study investigated whether patients with a history of human papillomavirus (HPV) infection are at increased risk of developing psoriasis. METHODS:We enrolled 66 274 patients with HPV infection between 1997 and 2013 from the Taiwan National Health Insurance Research Database, and compared them with cont...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa027
更新日期:2020-06-01 00:00:00
abstract::Biological interference among viral agents might have significant implications for disease prevention and therapy. Field data for influenza yield conflicting evidence concerning the independence of infection rates, or disease severity, for two co-circulating viruses. To examine the effects of several assumed modes of ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.2.444
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Women in developing countries often continue their agricultural work during late pregnancy. Whether this adversely affects birthweight is not clear from previous studies as few controlled for confounding factors. This study seeks to clarify this issue. METHODS:This retrospective cohort study investigated 95...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/28.3.469
更新日期:1999-06-01 00:00:00
abstract::In order to study differences in mortality and causes of death between HIV positive and HIV negative intravenous drug users (IVDU), 1009 (180 HIV positive and 829 HIV negative) IVDU in Oslo, Norway, were followed from their first HIV test for a mean period of 36 months (range 1-67 months). Eighty-seven (55 HIV negativ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.2.315
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:During pregnancy, woman and fetus exchange small quantities of cells, and their persistence at later times is termed microchimerism. Microchimerism is known to substantially impact on women's later health. This study examined the survival of women according to male microchimerism status. METHODS:Male microc...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt230
更新日期:2014-02-01 00:00:00
abstract::This paper contains part of the results of a repetitive and comprehensive analysis of accidents among bus drivers. In a series of articles different aspects of the aetiology of bus drivers' accidents will be highlighted. The results presented indicate a strong negative association of experience with accident risk, mod...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.1.35
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:In spite of an improving trend, childhood mortality in rural sub-Saharan Africa remains high and has recently risen in some countries. The factors associated with the long-term decline in childhood mortality are poorly known, due to a lack of data. METHODS:A Senegalese rural population has been under demogr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.6.1286
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:The incidence of hepatitis C (HCV) infection among injecting drug users (IDUs) in Dublin is particularly high by international standards. The most robust predictor of an IDU's HCV status is his or her total number of lifetime injecting episodes. It has been proposed that participation in specific unsafe inje...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh347
更新日期:2005-02-01 00:00:00
abstract::Chronic diseases are a global problem, yet information on their determinants is generally scant in low- and middle-income countries. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) aims to contribute relevant information regarding the development and progression of clinical and subclinical chronic disea...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyu027
更新日期:2015-02-01 00:00:00
abstract::Corporate influences on epidemiology have become stronger and more pervasive in the last few decades, particularly in the contentious fields of pharmacoepidemiology and occupational epidemiology. For every independent epidemiologist studying the side effects of medicines and the hazardous effects of industrial chemica...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/dym270
更新日期:2008-02-01 00:00:00
abstract::The area under the receiver operating characteristic (ROC) curve (AUC) is commonly used for assessing the discriminative ability of prediction models even though the measure is criticized for being clinically irrelevant and lacking an intuitive interpretation. Every tutorial explains how the coordinates of the ROC cur...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyz274
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Sub-Saharan Africa (SSA) has the highest burden of HIV in the world and a rising prevalence of cardiometabolic disease; however, the interrelationship between HIV, antiretroviral therapy (ART) and cardiometabolic traits is not well described in SSA populations. METHODS:We conducted a systematic review and m...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyt198
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:This prospective study was performed in order to investigate the effect of baseline body mass index (BMI), BMI changes, baseline alcohol consumption, and changes in alcohol consumption on liver enzyme activity. METHODS:This study population consisted of 6846 male workers in a steel manufacturing company who...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.4.766
更新日期:2001-08-01 00:00:00
abstract::A case-control study of risk factors for child diarrhoeal disease was undertaken in a rural area of Nicaragua. Some 1229 children under the age of five were matched with an equal number of children of the same age presenting with other illnesses unrelated to water and sanitation. The main types of water supply were sa...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.2.527
更新日期:1991-06-01 00:00:00
abstract::The CARTaGENE (CaG) study is both a population-based biobank and the largest ongoing prospective health study of men and women in Quebec. In population-based cohorts, participants are not recruited for a particular disease but represent a random selection among the population, minimizing the need to correct for bias i...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys160
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The male:female (M:F) mortality ratio for under-five mortality varies considerably across and within societies. Maternal education has been linked to better outcomes for girls, but the evidence is mixed. We examined how the M:F ratio for under-five mortality varies by maternal education in sub-Saharan Africa...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys201
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Exercise can suppress androgen production and may thus decrease the risk of prostate cancer. However, findings from epidemiological studies assessing physical activity and risk of prostate cancer are inconsistent. METHODS:We prospectively examined the association between physical activity and prostate cance...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章
doi:10.1093/ije/29.1.29
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Nicotine dependence is a significant public health problem. This study attempted to characterize the prevalence and familial aggregation of nicotine dependence in China. METHODS:In 1998, we initiated a community-based cross-sectional study among residents of the Yuexi County in Anqing, China. A total of 991...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ije/29.2.248
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Meningococcal meningitis epidemics are frequent in the Sahel zone of Africa but there is little information on the frequency of long-term sequelae. We analysed excess mortality in the two years following the 1997 epidemic in northern Ghana and carried out a case-control study to assess sequelae in the surviv...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.6.1440
更新日期:2001-12-01 00:00:00