Abstract:
:The CARTaGENE (CaG) study is both a population-based biobank and the largest ongoing prospective health study of men and women in Quebec. In population-based cohorts, participants are not recruited for a particular disease but represent a random selection among the population, minimizing the need to correct for bias in measured phenotypes. CaG targeted the segment of the population that is most at risk of developing chronic disorders, that is 40-69 years of age, from four metropolitan areas in Quebec. Over 20,000 participants consented to visiting 1 of 12 assessment sites where detailed health and socio-demographic information, physiological measures and biological samples (blood, serum and urine) were captured for a total of 650 variables. Significant correlations of diseases and chronic conditions are observed across these regions, implicating complex interactions, some of which we describe for major chronic conditions. The CaG study is one of the few population-based cohorts in the world where blood is stored not only for DNA and protein based science but also for gene expression analyses, opening the door for multiple systems genomics approaches that identify genetic and environmental factors associated with disease-related quantitative traits. Interested researchers are encouraged to submit project proposals on the study website (www.cartagene.qc.ca).
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Awadalla P,Boileau C,Payette Y,Idaghdour Y,Goulet JP,Knoppers B,Hamet P,Laberge C,CARTaGENE Project.doi
10.1093/ije/dys160subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1285-99issue
5eissn
0300-5771issn
1464-3685pii
dys160journal_volume
42pub_type
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