Abstract:
BACKGROUND:Exposure to a pre-natal famine environment has been associated with a persistent decrease in DNA methylation of the IGF2 gene, although study findings on other loci have been highly variable. There have been no studies to date of the relation between pre-natal famine and overall global DNA methylation in adulthood. METHODS:Our study population includes 350 births with pre-natal exposure to the Dutch famine of 1944-45 selected from three birth clinics, 290 births from these clinics born before or after the famine as unexposed time controls and 307 same-sex siblings of either birth group as unexposed family controls. All study subjects were interviewed and underwent a medical examination at a mean age of 58 years when blood samples were also collected. As measures of genomic DNA methylation, we analysed two repetitive elements, LINE-1 (long interspersed nucleotide element 1) and Sat2 (Satellite 2 DNA sequence) by pyrosequencing and MethyLight, respectively, and overall genomic DNA methylation using the Luminometric methylation assay (LUMA). RESULTS:Mean DNA methylation by LUMA was 75.2% [standard deviation (SD) 4.7], by LINE-1 was 77.1% (SD 2.5) and by Sat2 was 122.2 (SD 56.2). Pre-natal famine exposure was associated with negligible changes in all three assays {LUMA: -0.16% [95% confidence interval (95% CI) -0.49 to 0.81], P = 0.63; LINE-1: -0.05 % (95% CI -0.33 to 0.22), P = 0.70; and Sat2: -0.51% (95% CI -7.38 to 6.36), P = 0.88} relative to unexposed controls, adjusting for age at examination and within family clustering. CONCLUSION:Our results show no relation between overall global DNA methylation in adults and pre-natal famine exposure. Further work should focus on selected regions in the genome that may be differentially methylated in response to changes in early life exposures and predict adult health outcomes.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Lumey LH,Terry MB,Delgado-Cruzata L,Liao Y,Wang Q,Susser E,McKeague I,Santella RMdoi
10.1093/ije/dyr137subject
Has Abstractpub_date
2012-02-01 00:00:00pages
116-23issue
1eissn
0300-5771issn
1464-3685pii
dyr137journal_volume
41pub_type
杂志文章abstract::This case-control study was designed to determine whether males who were exposed to diethylstilboestrol (DES) in utero are at increased risk of testicular cancer. Questionnaires were completed for 79 residents of Connecticut, who were diagnosed with primary cancer of the testes between 1945 and approximately six month...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.4.738
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:A growing body of literature suggests that physical activity may be a protective factor against hip fracture. METHODS:To study the association between hip fracture risk and recreational physical activity at various ages, changes in activity during adult life, occupational physical activity and how risks var...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/29.2.308
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:It is well established now that the incidence of schizophrenia is extremely high for several ethnic minority groups in western Europe, but there is considerable variation among groups. We investigated whether the increased risk among these groups depends upon the degree to which they perceive discrimination ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dym085
更新日期:2007-08-01 00:00:00
abstract:Background:Bloodstream infections (BSI) cause considerable morbidity and mortality, and primary prevention should be a priority. Lifestyle factors are of particular interest since they represent a modifiable target. Methods:We conducted a prospective cohort study among participants in the population-based Norwegian HU...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx091
更新日期:2017-10-01 00:00:00
abstract::The paper reports on the trends of induced abortion in Italy since its legalization in 1978. Data collected through the national surveillance system show that the abortion rates and ratios in Italy, after an initial increase, have been stable in the last four years, and are comparable to those of other European countr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/15.3.343
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:France has the second highest number of variant Creutzfeldt-Jakob disease (vCJD) cases worldwide. Imports of bovine carcasses from the UK probably constituted the main source of exposure of the French population to the bovine spongiform encephalopathy (BSE) agent. Meat products consumed whilst visiting the U...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh374
更新日期:2005-02-01 00:00:00
abstract::In 1983 and 1984, surveys were conducted in four Chinese population samples, urban and rural for both Beijing and Guangzhou, as part of PRC-USA collaborative research in cardiovascular and cardiopulmonary epidemiology. Serum total cholesterol (TC), HDL-cholesterol (HDL-C), and triglycerides (TG) were measured in 4280 ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.5.893
更新日期:1992-10-01 00:00:00
abstract::There has been a general decline in mortality from ischaemic heart disease (IHD) in Finland since the beginning of the 1970s. An intensified preventive programme was started in the province of North Karelia in 1972. Between 1974 and 1979 the decline in IHD mortality in North Karelian men was steeper than that in the r...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Peptic ulcer (PU) disease is the cause of substantial morbidity and mortality in a number of countries including Australia. Despite diagnostic and treatment advances, sustained mortality from PU disease has been reported. To understand this problem a birth cohort analysis using the Median Polish Technique (MPT) was pe...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.6.1085
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism. METHODS:We used multivariable linear regression and a negative control design to examine offspring epigenome-wide DNA me...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyv042
更新日期:2015-08-01 00:00:00
abstract::The European Prospective Investigation of Cancer (EPIC) is a 10-country collaborative study in which EPIC-Norfolk is one of the UK centres. EPIC-Norfolk examined 25 639 men and women resident in East Anglia (aged 40-79 years), between 1993 and 1997. The EPIC collaboration was set up to examine the dietary determinants...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt086
更新日期:2014-08-01 00:00:00
abstract::Using routinely collected maternity discharge data from 250,000 women in Scotland, we examined the risks of late spontaneous abortion and preterm delivery during the period 20 up to 36 weeks of gestation. Gestational age is treated as a fetal survival time and the risks of delivery associated with a history of spontan...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.2.456
更新日期:1991-06-01 00:00:00
abstract::Despite the extreme differences in the incidence of lung cancer between black and white Americans of each sex, little information is available on the sex-race-specific lung cancer risk due to tobacco use. In the current study, case-control data were examined for sex-race differences in the lung cancer risk associated ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.4.592
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease remains largely unknown. We investigated whether birth order is associated with the risk of childhood diabetes by performing a pooled analysis of previous studies. METHO...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyq207
更新日期:2011-04-01 00:00:00
abstract::The effects of household exposure to cigarette smoke on hospitalization and incidence of respiratory illness were examined among 2227 children at Chang-Ning District, Shanghai Municipality, People's Republic of China. The passive smoking quantity was estimated by total daily cigarette consumption of family members and...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.2.348
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that small newborns who present rapid postnatal growth may have an increased risk of chronic diseases in adulthood. On the other hand, it is widely assumed that catch-up growth is desirable for low birthweight children, but the literature on this subject is limited. METHODS:Population...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.6.1325
更新日期:2001-12-01 00:00:00
abstract::Medical conditions related to hormonal abnormalities were investigated in a case-control study of breast cancer among women who attended a screening centre. Information was obtained by telephone interview regarding physician-diagnosed medical conditions such as thyroid or liver diseases, diabetes, and hypertension, as...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.6.1000
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:A number of studies have reported that increased consumption of natural products reduced the risk of cancer. Our previous case-control studies have shown a significant reduction in the risk of cancer development among those who regularly consumed ginseng. We conducted a prospective cohort study to evaluate t...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.3.359
更新日期:1998-06-01 00:00:00
abstract::The problems and prospects in the use of case-control studies to assess the effects of improvements in environmental sanitation on diarrhoea morbidity are discussed on the basis of two field studies. It is concluded that an adequate design is available for assessing the effects of a single improvement on diarrhoeal di...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.2.441
更新日期:1988-06-01 00:00:00
abstract::An analysis is made of the association between density factors and the profile of cause specific death rates in small areas (Bezirke) of Hannover, Germany, in 1968-69. Evaluation of urban ecological methods and logic is done to determine the plausibility of making meaningful statements about cause specific death risks...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/6.3.203
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND:Early-life social environment has been suggested to play an important role during the development of Helicobacter pylori-related gastric diseases. We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany. METHOD...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyp250
更新日期:2010-02-01 00:00:00
abstract::A community survey was conducted in 1989 in Conakry, Guinea to determine reasons for low vaccination coverage. Some 377 children aged 12-23 months and their guardians were studied, of whom 204 (54%) had vaccination records. According to their records 19% of children were fully and correctly vaccinated. Thirty-nine inc...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.4.1099
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Secular trends in cardiovascular risk factors have been described, but few studies have examined simultaneously the effects of both ageing and secular trends within the same cohort. METHODS:Development of cardiovascular risk factors over the past three decades was analysed using serial measurements from 10 ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt279
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Bundling, which consists of wrapping an infant for prolonged periods in a sheepskin cover after dried cow dung is applied, is a common and apparently unique practice limited to the rural, mountainous regions of Northern Pakistan. The practice is initiated at various ages during the neonatal period. Its poten...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.4.879
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:In large-scale epidemiological studies of stillbirths and neonatal deaths a method is needed to replace detailed medical record audits in order to determine the cause of death. METHODS:A computer-based method is presented for determination of the cause of death in stillbirths and in neonatal deaths. It util...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.6.1298
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:We explored methods to develop uncorrelated variables for epidemiological analysis models. They were used to examine associations between respiratory health outcomes and multiple household risk factors. METHODS:We analysed data collected in the Four Chinese Cities Study (FCCS) to examine health effects on p...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyg278
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modi...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/dys114
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Increasing life expectancy has brought public health concern about the increase in prevalence of disability in old age. Reducing the prevalence of disability in older age requires the identification of preventable or modifiable risk factors earlier in life. We have examined the relationship between lifestyle...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Hand dominance and spinal posture were studied for their prediction of the development of thoracic hyperkyphosis during the pubertal growth spurt. METHODS:The cohort consisted of all the fourth-grade school children of the Western School District of Helsinki, Finland, in the spring of 1986. They were examin...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.6.1178
更新日期:1995-12-01 00:00:00
abstract::Cirrhosis mortality death rates in Ontario for ages 20 and over declined from a high of 9.3 per 100,000 in 1911 to a low of 5.6 per 100,000 in 1919 (p less than 0.001) and after a 17-year period of relative stability, rose steadily to a high of 19.7 per 100,000 in 1975 (p less than 0.0001) and then declined to 13.3 pe...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.1.199
更新日期:1991-03-01 00:00:00