Abstract:
BACKGROUND:Bundling, which consists of wrapping an infant for prolonged periods in a sheepskin cover after dried cow dung is applied, is a common and apparently unique practice limited to the rural, mountainous regions of Northern Pakistan. The practice is initiated at various ages during the neonatal period. Its potential contribution to neonatal tetanus (NNT) had not been evaluated. METHODS:A population-based, matched, case-control study was undertaken to assess bundling and other factors potentially related to NNT in rural parts of the Northern Areas, Pakistan. RESULTS:Bundling instituted within the first 3 days of life was a substantial risk factor for NNT (odds ratio [OR] = 2.5, 95% confidence interval [CI]: 1.3-4.9). Other factors found risky for NNT were delivery on a straw surface and pre-delivery intravaginal application of ghee to the mothers. Handwashing by the delivery attendant and use of a new razor to cut the umbilical cord were protective. CONCLUSIONS:Bundling is a significant risk factor for NNT in the mountainous regions of Northern Pakistan. While this practice is seemingly limited to these remote areas, the findings have broad implications since they indicate that NNT can derive from exposures of the umbilical wound at any time during the first several days of life. Thus, clean cord care at delivery is not itself sufficient to prevent NNT and control programmes need to address post-delivery sources of NNT. :Bundling consists of wrapping an infant for prolonged periods in a sheepskin cover after dried cow dung is applied. This is a common practice among the inhabitants of the rural, mountainous regions of Northern Pakistan which is initiated at various ages during the neonatal period. A population-based, matched, case-control study was conducted to the determine the role of bundling and other factors potentially related to the incidence and prevalence of neonatal tetanus (NT) in rural parts of the Northern Areas, Pakistan. Bundling instituted within the first 3 days of life was found to be a substantial risk factor for NT. Delivery on a straw surface and the pre-delivery intravaginal application of ghee among mothers are also risk factors for NT. Handwashing by the delivery attendant and use of a new razor to cut the umbilical cord were protective. These findings demonstrate that NT can result from exposures of the umbilical wound any time during the first several days of life. Clean cord care at delivery alone is therefore not sufficient to prevent NT. NT prevention and control programs need to take these findings into account and operate accordingly.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Bennett J,Schooley M,Traverso H,Agha SB,Boring Jdoi
10.1093/ije/25.4.879subject
Has Abstractpub_date
1996-08-01 00:00:00pages
879-84issue
4eissn
0300-5771issn
1464-3685journal_volume
25pub_type
杂志文章abstract::A serological survey of 300 Israeli intravenous drug addicts in 1988-1989, showed a 2.3% prevalence of antibodies to human immunodeficiency virus (HIV), very similar to the finding of a previous study (2%) performed in the same population in 1986. Travel and drug injection abroad continue to be the most significant pr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.3.561
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Alcohol use is associated with breast cancer in many epidemiological studies. Most, however, have measured risk from recent consumption patterns, and only a few include analyses for duration of drinking or age that a woman started to drink. The authors studied the effect of these variables, as well as of rec...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.5.915
更新日期:1997-10-01 00:00:00
abstract::The prevalence of diabetes, the interrelationship of blood glucose, serum insulin, and lipids, and their relationship to ischemic heart dise ase in a rural Jamaican community were investigated. The people were mo stly of West African descent. Occupations were primarily agricultural w ith much physical labor. Approx...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/1.2.157
更新日期:1972-07-01 00:00:00
abstract::Data from the Stockholm Health of the Population Study in 1984 (n = 6217) show small differences in mean alcohol consumption and in the prevalence of high consumers in various socioeconomic and educational categories of both sexes. Among young people mean consumption was higher in those who had low formal education, e...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.4.842
更新日期:1989-12-01 00:00:00
abstract::In an extensive health survey 115 male viscose rayon workers exposed to carbon disulphide (CS2) and 76 referents not exposed to this chemical were interviewed using the WHO cardiovascular questionnaire and responded to a self-administered questionnaire. A 12-lead ECG was taken and coded using the Minnesota code. Blood...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.4.745
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:The male:female (M:F) mortality ratio for under-five mortality varies considerably across and within societies. Maternal education has been linked to better outcomes for girls, but the evidence is mixed. We examined how the M:F ratio for under-five mortality varies by maternal education in sub-Saharan Africa...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys201
更新日期:2013-02-01 00:00:00
abstract::Thyroid status is known to have an important bearing on the ability of a woman to conceive, and to bring a normal infant to term. Thyroid status has changed in a number of previously iodine deficient countries as a result of recent iodization programmes. In this study, examination has been made of changes in the rates...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/8.2.137
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:End-stage renal disease (ESRD) incidence and prevalence are increasing in many countries worldwide. Due to the high cost of therapy, predicting future numbers of patients requiring dialysis and transplantation is necessary for health care planners. Projecting therapy-specific chronic disease prevalence is in...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.2.274
更新日期:1998-04-01 00:00:00
abstract::In tropical Africa, parasitic and infective diseases remain the predominant causes of mortality and morbidity, and health and epidemiological services are poorly developed. Experience elsewhere has shown the value of surveillance in the control of communicable diseases and this paper contains a brief review of the use...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/5.1.39
更新日期:1976-03-01 00:00:00
abstract::In September 1665, an outbreak of plague occurred in Eyam, a small village 10 miles west of Sheffield, in an isolated valley of Derbyshire. Eighty per cent of the population died during the 14 months of the epidemic, a greater proportion than any other community in England. When plague threatened to cause panic and de...
journal_title:International journal of epidemiology
pub_type: 历史文章,杂志文章
doi:10.1093/ije/15.3.379
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:The role of trigger factors in acute cardiovascular events has been much studied in the past few years. A recent study analysed changes in the rates of cardiac emergencies in Bavaria (Germany) during the last Football World Cup. The authors reported a 2.7-fold increase in the incidence of cardiac emergencies...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyq007
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The majority of tuberculosis (TB) cases in low-incidence countries occur in migrants. Only few studies have assessed the long-term TB risk in migrants after immigration, and datasets have not considered this across a range of diverse migrant groups. This nationwide study aimed to investigate long-term TB ris...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa063
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Exercise can suppress androgen production and may thus decrease the risk of prostate cancer. However, findings from epidemiological studies assessing physical activity and risk of prostate cancer are inconsistent. METHODS:We prospectively examined the association between physical activity and prostate cance...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章
doi:10.1093/ije/29.1.29
更新日期:2000-02-01 00:00:00
abstract::We undertook a case-control study to investigate the association between chemicals in maternal drinking water consumed during pregnancy and congenital heart disease in the offspring. Two hundred and seventy affected children and 665 healthy children were enrolled in the study. Information on contaminant levels in mate...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.3.589
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:We undertook a systematic review and meta-analysis of perinatal variables in relation to testicular cancer risk, with a specific focus upon characteristics of the son. METHODS:Literature databases Scopus, EMBASE, PubMed and Web of Science were searched using highly sensitive search strategies. Of 5865 refer...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyq120
更新日期:2010-12-01 00:00:00
abstract::A 10-year prospective study of Hawaii Japanese males with partial gastrectomy shows that the age-adjusted mortality rates in men with partial gastrectomy were slightly higher than in those with an intact stomach, but the difference failed to achieve statistical significance. This excess of mortality is due, in part, t...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/13.3.299
更新日期:1984-09-01 00:00:00
abstract::Examinations of 'healthy' men in Helsinki and in rural west and east Finland in 1956 included estimation of total cholesterol and that in the HDL and beta fractions separated by electrophoresis. Vital status to the end of 1980 has been ascertained for all but eight of the 526 men aged 35-61 and for all but two of 261 ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/13.4.428
更新日期:1984-12-01 00:00:00
abstract::We examine the resource implications of two potential health services aimed at preventing congenital toxoplasmosis: a screening service involving serological surveillance for toxoplasma infection in pregnant women and its prophylactic treatment; and a health education campaign to help pregnant women avoid acquiring to...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/13.1.65
更新日期:1984-03-01 00:00:00
abstract::The predisposing and precipitating causes of acute myocardial infarction (MI) are multiple; furthermore, different individuals may have different susceptibility, to a large extent genetically determined, to each of them. In spite of the complex aetiology of MI and of our limited knowledge of the causes responsible for...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/30.suppl_1.s41
更新日期:2001-10-01 00:00:00
abstract::High-income countries are experiencing an obesity epidemic that follows a socioeconomic gradient, affecting groups of lower socioeconomic status disproportionately. Recent clinical findings have suggested new perspectives for the prevention and treatment of obesity, using personalized dietary approaches. Precision nut...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy274
更新日期:2019-04-01 00:00:00
abstract::John Snow was a genius in epidemiology. His achievement was to evolve an elegant, internally and externally consistent theory which concerned the mechanisms and processes involved in every aspect of the subject he had chosen to study. In order to do this he did not restrict himself to any method. He used all skills av...
journal_title:International journal of epidemiology
pub_type: 传,历史文章,杂志文章
doi:10.1093/ije/12.4.393
更新日期:1983-12-01 00:00:00
abstract::Prospective data from the Matlab surveillance area in rural Bangladesh, 1974-1982, were used in this study to show that divorced and never-married adults (aged 15-44 years) had significantly higher mortality than their currently married peers with differences in disability status accounting for some of this excess ris...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.3.445
更新日期:1993-06-01 00:00:00
abstract::One task faced by public health surveillance practitioners is the timely identification of data patterns that might suggest the onset of an epidemic period. Many available techniques for analysis of surveillance data are based on sequential procedures, which predict expected numbers of cases and compare this estimate ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.2.408
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Women in developing countries often continue their agricultural work during late pregnancy. Whether this adversely affects birthweight is not clear from previous studies as few controlled for confounding factors. This study seeks to clarify this issue. METHODS:This retrospective cohort study investigated 95...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/28.3.469
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Under-5 mortality is unacceptably high in many countries, the burden of which is mainly borne by the poor. Whereas country characteristics are known to influence under-5 mortality, it is unknown whether these have a different impact on the poor and the rich. We aimed to describe how the association between u...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyi190
更新日期:2005-12-01 00:00:00
abstract::This population-based study examines whether dietary intake in middle-aged Italian women is influenced by alcohol drinking habits. The 499 participants were interviewed using a dietary history questionnaire designed to investigate alcohol consumption. Mean intake of total and non-alcohol energy increased progressively...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.3.663
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Aetiological profiles of non-Hodgkin's lymphoma (NHL) may differ depending upon whether the disease is inheritance-related or sporadic. Because familial risk (a probable surrogate of inheritance-relatedness) of NHL is influenced by haematolymphoproliferative malignancies (HLPM), we evaluated whether non-fami...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.4.818
更新日期:2001-08-01 00:00:00
abstract::Blood samples from 382 children between the ages of one and 15 years were tested for anti-chlamydial antibody. A low prevalence of antibody against Chlamydia trachomatis was found among children under the age of seven years. Antibody against the Chlamydial agent C IOL-207 was rare before the age of five years, but was...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/13.4.491
更新日期:1984-12-01 00:00:00
abstract::The role of rotavirus in non-bacterial gastroenteritis in Kuwait was investigated. Employing electronmicroscopy (EM) and enzyme-linked-immuno-sorbent-assay (ELISA) techniques, the virus was detected in the stools of 42 of 274 (15.3%) infants with the disease. A statistically significant association (P less than 0.05) ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/9.4.355
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism. METHODS:We used multivariable linear regression and a negative control design to examine offspring epigenome-wide DNA me...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyv042
更新日期:2015-08-01 00:00:00