Risk of variant Creutzfeldt-Jakob disease in France.

Abstract:

BACKGROUND:France has the second highest number of variant Creutzfeldt-Jakob disease (vCJD) cases worldwide. Imports of bovine carcasses from the UK probably constituted the main source of exposure of the French population to the bovine spongiform encephalopathy (BSE) agent. Meat products consumed whilst visiting the UK have also been considered as a possible source of exposure. METHODS:We estimated the number of future vCJD cases in France using a simulation approach. Both the distribution of the vCJD incubation period and the age-dependent susceptibility to the BSE agent were estimated from UK data. The French epidemic was simulated by gender and birth-cohort from data on the infectivity of UK bovine tissues and simulations of the French consumption of infected beef products. We also used data on travel to the UK between 1980 and 1995. RESULTS:We predicted 33 future cases of vCJD: 12 in the 1940-69 birth-cohort and 21 in the post-1969 birth-cohort. No case was predicted in the pre-1940 cohort. Based on our model, simulated vCJD cases occurred later in the older (1940-69) than in the younger cohort (post-1969). Age at onset was stable in the post-1969 cohort and increased in the older cohort. The model predicted a small excess of male patients. No case was attributed to travels in the UK. CONCLUSIONS:This modelling confirms that a large vCJD epidemic in France is very unlikely. Since France (where 60% of the total British exports of bovine carcasses were exported) has been highly exposed to the BSE agent, our results are reassuring for most countries worldwide.

journal_name

Int J Epidemiol

authors

Chadeau-Hyam M,Alpérovitch A

doi

10.1093/ije/dyh374

keywords:

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

46-52

issue

1

eissn

0300-5771

issn

1464-3685

pii

dyh374

journal_volume

34

pub_type

杂志文章
  • Factor analysis of household factors: are they associated with respiratory conditions in Chinese children?

    abstract:BACKGROUND:We explored methods to develop uncorrelated variables for epidemiological analysis models. They were used to examine associations between respiratory health outcomes and multiple household risk factors. METHODS:We analysed data collected in the Four Chinese Cities Study (FCCS) to examine health effects on p...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyg278

    authors: Qian Z,Zhang J,Korn LR,Wei F,Chapman RS

    更新日期:2004-06-01 00:00:00

  • Smoking among junior high school students in Nagoya, Japan.

    abstract::A questionnaire survey was administered in January 1982 to 3090 junior high school boys and girls in Nagoya, Japan. The proportion of current regular smokers who smoke at least one cigarette per week was 3.6% for boys and 0.5% for girls. By the third grade this had increased to 6.9% and 1.2% respectively for each sex....

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/17.4.814

    authors: Ogawa H,Tominaga S,Gellert G,Aoki K

    更新日期:1988-12-01 00:00:00

  • A competing-risk model based on the life table procedure in epidemiological studies.

    abstract::In this paper, a new non-parametric competing-risk model is proposed. This model takes relative susceptibility into account, and is thus free from the usual assumption of independence between competing causes of death. Another feature of the model is the adjustments of survivors and deaths as a results of the eliminat...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/6.2.153

    authors: Wong O

    更新日期:1977-06-01 00:00:00

  • Cultural concepts of distress and psychiatric disorders: literature review and research recommendations for global mental health epidemiology.

    abstract:BACKGROUND:Burgeoning global mental health endeavors have renewed debates about cultural applicability of psychiatric categories. This study's goal is to review strengths and limitations of literature comparing psychiatric categories with cultural concepts of distress (CCD) such as cultural syndromes, culture-bound syn...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/ije/dyt227

    authors: Kohrt BA,Rasmussen A,Kaiser BN,Haroz EE,Maharjan SM,Mutamba BB,de Jong JT,Hinton DE

    更新日期:2014-04-01 00:00:00

  • Measuring effectiveness in community randomized trials of HIV prevention.

    abstract:BACKGROUND:Complicated HIV transmission dynamics make it unclear how to design and interpret results from community-randomized controlled trials (CRCT) of interventions to prevent infection. METHODS:Mathematical modelling was used to investigate the effectiveness of interventions to prevent HIV transmission aimed at h...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dym232

    authors: Hallett TB,Garnett GP,Mupamberiyi Z,Gregson S

    更新日期:2008-02-01 00:00:00

  • 'Leopard skin' as a rapid diagnostic index for estimating the endemicity of African onchocerciasis.

    abstract::A study was made in five rural districts of Kwara State, Nigeria to assess the possible use of 'leopard skin' (Ls) as a rapid diagnostic technique for estimating the endemicity of African onchocerciasis. The findings revealed that there is a positive association between the percentage of subjects with skin microfilari...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/16.4.590

    authors: Edungbola LD,Alabi TO,Oni GA,Asaolu SO,Ogunbanjo BO,Parakoyi BD

    更新日期:1987-12-01 00:00:00

  • Exposure to ultraviolet radiation and risk of malignant lymphoma and multiple myeloma--a multicentre European case-control study.

    abstract:BACKGROUND:Three recent studies have reported a decreased risk of non-Hodgkin lymphoma (NHL) for high ultraviolet (UV) radiation exposure. METHODS:We conducted a multicentre case-control study during 1998-2004 in France, Germany, Ireland, Italy and Spain, comprising 1518 cases of NHL, 268 cases of Hodgkin lymphoma, 24...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ije/dyn092

    authors: Boffetta P,van der Hel O,Kricker A,Nieters A,de Sanjosé S,Maynadié M,Cocco PL,Staines A,Becker N,Font R,Mannetje A',Goumas C,Brennan P

    更新日期:2008-10-01 00:00:00

  • Nicotine dependence and its familial aggregation in Chinese.

    abstract:BACKGROUND:Nicotine dependence is a significant public health problem. This study attempted to characterize the prevalence and familial aggregation of nicotine dependence in China. METHODS:In 1998, we initiated a community-based cross-sectional study among residents of the Yuexi County in Anqing, China. A total of 991...

    journal_title:International journal of epidemiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ije/29.2.248

    authors: Niu T,Chen C,Ni J,Wang B,Fang Z,Shao H,Xu X

    更新日期:2000-04-01 00:00:00

  • Impact on sexually transmitted disease spread of increased condom use by young females, 1987-1992.

    abstract:BACKGROUND:Sexual behaviour data are crucial for understanding the spread of sexually transmitted diseases (STD). Over a period (1987-1992) in which the HIV epidemic increased public awareness of safe sexual practices, we describe predictors of condom use, changes in condom use over time, and the estimated effects of t...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/24.4.813

    authors: Stigum H,Magnus P,Veierød M,Bakketeig LS

    更新日期:1995-08-01 00:00:00

  • Optimal timing of antiretroviral treatment initiation in HIV-positive children and adolescents: a multiregional analysis from Southern Africa, West Africa and Europe.

    abstract:Background:There is limited knowledge about the optimal timing of antiretroviral treatment initiation in older children and adolescents. Methods:A total of 20 576 antiretroviral treatment (ART)-naïve patients, aged 1-16 years at enrolment, from 19 cohorts in Europe, Southern Africa and West Africa, were included. We c...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ije/dyw097

    authors: Schomaker M,Leroy V,Wolfs T,Technau KG,Renner L,Judd A,Sawry S,Amorissani-Folquet M,Noguera-Julian A,Tanser F,Eboua F,Navarro ML,Chimbetete C,Amani-Bosse C,Warszawski J,Phiri S,N'Gbeche S,Cox V,Koueta F,Giddy J,Sy

    更新日期:2017-04-01 00:00:00

  • Characteristics of women under 20 with cervical intraepithelial neoplasia.

    abstract::The relationship between risk of cervical neoplasia and various sociodemographic, reproductive and sexual characteristics was studied in 126 women (cases) with an abnormal Papanicolaou test finding and 1914 controls seen at the same clinic in which cases were detected but showing no evidence of cervical neoplasia. All...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/15.4.477

    authors: Zaninetti P,Franceschi S,Baccolo M,Bonazzi B,Gottardi G,Serraino D

    更新日期:1986-12-01 00:00:00

  • Cohort profile: the MUg Observational Cohort.

    abstract::Mildmay Uganda (MUg), an HIV treatment centre near Kampala, the capital of Uganda, has entered into a memorandum of understanding to collaborate with Canadian researchers at the University of Ottawa to develop their research programme and develop an observational cohort database (the MUg observational cohort). The pri...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dys170

    authors: Funk A,Kanters S,Nansubuga M,Mwehire D,Featherstone A,Druyts E,Odiit M,Mills EJ

    更新日期:2012-12-01 00:00:00

  • End-stage renal disease projections for Canada to 2005 using Poisson and Markov models.

    abstract:BACKGROUND:End-stage renal disease (ESRD) incidence and prevalence are increasing in many countries worldwide. Due to the high cost of therapy, predicting future numbers of patients requiring dialysis and transplantation is necessary for health care planners. Projecting therapy-specific chronic disease prevalence is in...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/27.2.274

    authors: Schaubel DE,Morrison HI,Desmeules M,Parsons D,Fenton SS

    更新日期:1998-04-01 00:00:00

  • Is tuberculin skin testing useful to diagnose latent tuberculosis in BCG-vaccinated children?

    abstract:BACKGROUND:The tuberculin skin test (TST) is the most commonly used tool to detect infection with Mycobacterium tuberculosis. We sought to determine whether tuberculin skin testing is useful to detect latent infection by M. tuberculosis in a population that was vaccinated with the Bacille Calmette Guérin (BCG) vaccine....

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyl213

    authors: García-Sancho F MC,García-García L,Jiménez-Corona ME,Palacios-Martínez M,Ferreyra-Reyes LD,Canizales-Quintero S,Cano-Arellano B,Ponce-de-León A,Sifuentes-Osornio J,Small P,DeRiemer K

    更新日期:2006-12-01 00:00:00

  • Childhood and adolescent leukaemia in a North American population.

    abstract:OBJECTIVE:This was to describe and analyse incidence and survival data on childhood leukaemias. SAMPLE:Incident leukaemia cases aged 0-19 from the cancer registry holdings of the province of Saskatchewan for the 60-year period 1932-1991 are the subject of this descriptive report. METHODS:Age-adjusted, age-specific, h...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/24.6.1100

    authors: Wang PP,Haines CS

    更新日期:1995-12-01 00:00:00

  • 50-year trends in US socioeconomic inequalities in health: US-born Black and White Americans, 1959-2008.

    abstract:BACKGROUND:Debates exist over whether health inequities are bound to rise as population health improves, due to health improving more quickly among the better off, with most analyses focused on mortality data. METHODS:We analysed 50 years of socioeconomic inequities in measured health status among US-born Black and Wh...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyu047

    authors: Krieger N,Kosheleva A,Waterman PD,Chen JT,Beckfield J,Kiang MV

    更新日期:2014-08-01 00:00:00

  • Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, placebo-controlled, primary prevention SU.VI.MAX trial.

    abstract:BACKGROUND:The effect of antioxidant vitamin and mineral supplementation on health is one of the most controversial issues in human nutrition. Our objective was to investigate the effect of nutritional doses of a combination of antioxidant vitamins and minerals on health-related quality of life (HRQoL) in a sample of h...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ije/dyr161

    authors: Briançon S,Boini S,Bertrais S,Guillemin F,Galan P,Hercberg S

    更新日期:2011-12-01 00:00:00

  • The epidemiology of peptic ulcer mortality 1953-1989: a birth cohort analysis.

    abstract::Peptic ulcer (PU) disease is the cause of substantial morbidity and mortality in a number of countries including Australia. Despite diagnostic and treatment advances, sustained mortality from PU disease has been reported. To understand this problem a birth cohort analysis using the Median Polish Technique (MPT) was pe...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/22.6.1085

    authors: Westbrook JI,Rushworth RL

    更新日期:1993-12-01 00:00:00

  • Dietary patterns and the risk of mortality: impact of cardiorespiratory fitness.

    abstract:BACKGROUND:While dietary patterns that are both predictive of chronic disease and mortality have been identified, the confounding effects of cardiorespiratory fitness have not been properly addressed. The primary objective was to assess the relation between dietary patterns with all-cause mortality, while controlling f...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyp191

    authors: Héroux M,Janssen I,Lam M,Lee DC,Hebert JR,Sui X,Blair SN

    更新日期:2010-02-01 00:00:00

  • A study on effectiveness of screening mammograms.

    abstract:BACKGROUND:So far, no randomized controlled trials with a mean mammographic screening interval of > or = 2 years has demonstrated statistically significant mortality reduction for women younger than age 50. The issue of screening frequency is vital in detection of primary breast cancer. METHODS:The study group consist...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/29.5.803

    authors: Ren JJ,Peer PG

    更新日期:2000-10-01 00:00:00

  • Is Trichomonas vaginalis a cause of cervical neoplasia? Results from a combined analysis of 24 studies.

    abstract:BACKGROUND:We conducted this combined analysis of available data from studies with information on this issue to clarify the association between Trichomonas vaginalis infection and cervical neoplasia. METHODS:We performed MEDLINE searches (1966-1993) using the key words and phrases 'trichomonas vaginitis' and 'neoplasm...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,meta分析

    doi:10.1093/ije/23.4.682

    authors: Zhang ZF,Begg CB

    更新日期:1994-08-01 00:00:00

  • The intergenerational impact of the African orphans crisis: a cohort study from an HIV/AIDS affected area.

    abstract:BACKGROUND:In sub-Saharan Africa, the prevalence of orphanhood among children has been greatly exacerbated by the HIV/AIDS pandemic. If orphanhood harms a child's development and these effects perpetuate into adult life, then the African orphan crisis could seriously jeopardize the continent's future generations. Wheth...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyn197

    authors: Beegle K,De Weerdt J,Dercon S

    更新日期:2009-04-01 00:00:00

  • Ethnic factors in multiple sclerosis: a review and critique of the epidemiological literature.

    abstract::A review of the international epidemiological literature is undertaken with the view of identifying the main demographic and sociocultural features of MS as they apply to ethnic groups. Ethnic groups are differentiated principally in terms of three variables: race, religion, and nationality. Although MS is present in ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/ije/17.1.14

    authors: Lowis GW

    更新日期:1988-03-01 00:00:00

  • The genetics of signal transduction and the effect of smoking on intrauterine growth.

    abstract::We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples po...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ije/30.2.400

    authors: Bottini E,Gloria-Bottini F,La Torre M,Lucarini N

    更新日期:2001-04-01 00:00:00

  • Effect of secular trends on age-related trajectories of cardiovascular risk factors: the Whitehall II longitudinal study 1985-2009.

    abstract:BACKGROUND:Secular trends in cardiovascular risk factors have been described, but few studies have examined simultaneously the effects of both ageing and secular trends within the same cohort. METHODS:Development of cardiovascular risk factors over the past three decades was analysed using serial measurements from 10 ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyt279

    authors: Hulmán A,Tabák AG,Nyári TA,Vistisen D,Kivimäki M,Brunner EJ,Witte DR

    更新日期:2014-06-01 00:00:00

  • Mortality and cancer incidence in Vietnamese refugees in England and Wales: a follow-up study.

    abstract::Mortality and cancer incidence were analysed in follow-up of a cohort of 3327 Vietnamese refugees who came to Britain after the end of the Vietnam war. Overall mortality of the refugees was very low compared to expectations based on England and Wales national rates: the all-cause standardized mortality ratio for males...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/20.1.13

    authors: Swerdlow Aj

    更新日期:1991-03-01 00:00:00

  • An overview of relations among causal modelling methods.

    abstract::This paper provides a brief overview to four major types of causal models for health-sciences research: Graphical models (causal diagrams), potential-outcome (counterfactual) models, sufficient-component cause models, and structural-equations models. The paper focuses on the logical connections among the different typ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/ije/31.5.1030

    authors: Greenland S,Brumback B

    更新日期:2002-10-01 00:00:00

  • Placental weight and birthweight: the relations with number of daily cigarettes and smoking cessation in pregnancy. A population study.

    abstract:Background:We studied associations of number of daily cigarettes in the first trimester with placental weight and birthweight in women who smoked throughout pregnancy, and in women who stopped smoking after the first trimester. Methods:We included all women with delivery of a singleton in Norway (n = 698 891) during 1...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyy110

    authors: Larsen S,Haavaldsen C,Bjelland EK,Dypvik J,Jukic AM,Eskild A

    更新日期:2018-08-01 00:00:00

  • Joint modelling of repeated measurement and time-to-event data: an introductory tutorial.

    abstract:BACKGOUND:The term 'joint modelling' is used in the statistical literature to refer to methods for simultaneously analysing longitudinal measurement outcomes, also called repeated measurement data, and time-to-event outcomes, also called survival data. A typical example from nephrology is a study in which the data from...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/ije/dyu262

    authors: Asar Ö,Ritchie J,Kalra PA,Diggle PJ

    更新日期:2015-02-01 00:00:00

  • Risk factors for invasive cervical cancer in Kenyan women.

    abstract:BACKGROUND:Few epidemiological investigations of invasive cervical cancer have been conducted in Sub-Saharan African populations. METHODS:Using information collected as part of the hospital-based World Health Organization (WHO) Collaborative Study of Neoplasia and Steroid Contraceptives, we examined potential risk fac...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/23.5.906

    authors: Williams MA,Kenya PR,Mati JK,Thomas DB

    更新日期:1994-10-01 00:00:00