Abstract:
BACKGROUND:The effect of antioxidant vitamin and mineral supplementation on health is one of the most controversial issues in human nutrition. Our objective was to investigate the effect of nutritional doses of a combination of antioxidant vitamins and minerals on health-related quality of life (HRQoL) in a sample of healthy French adults. METHODS:SU.VI.MAX is a randomized, double-blind, placebo-controlled, primary prevention trial in which a total of 8112 participants received a single capsule daily containing either placebo or vitamin C 120 mg, vitamin E 30 mg, beta-carotene 6 mg, selenium 100 μg and zinc 20 mg. Participants completed HRQoL questionnaires (SF36 and GHQ12) at baseline and after a mean of 76.0 ± 4.2 months. RESULTS:Scores for physical dimensions tended to decrease over time, whereas those for mental dimensions tended to improve. No differences in changes over time were observed between the supplement and placebo groups. Participants who believed that they received placebo had lower HRQoL scores than did those who thought they had received supplements [SF36 Bodily pain (-3.3), General health (-2.2), Vitality (-1.6) dimensions and physical component summary score (-1.1) in men, and in SF36 Social functioning (-2.3), General health (-1.4) dimensions and physical component summary score (-0.7) in women]. CONCLUSIONS:Long-term supplementation with antioxidant vitamins and minerals had no beneficial effect on HRQoL in this trial. This is contrary to conventional beliefs and claims that such an effect exists. Trial Registration "Primary Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals." NTC n 00272428 http://www.clinicaltrials.gov.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Briançon S,Boini S,Bertrais S,Guillemin F,Galan P,Hercberg Sdoi
10.1093/ije/dyr161subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1605-16issue
6eissn
0300-5771issn
1464-3685pii
dyr161journal_volume
40pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Smoking during pregnancy has been shown to increase the risks of several adverse birth outcomes. Associations with overweight and/or obesity in the offspring have also been suggested. We aim to investigate whether familial factors confound the association between maternal smoking during pregnancy and overwei...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyq064
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:While prior studies of thyroid cancer incidence within Belarus have increased since the 1986 Chernobyl reactor accident, the magnitude of increase is not well quantified. METHODS:Using Belarussian national cancer registry data, trends in average annual age-adjusted thyroid cancer incidence rates were examin...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh201
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:The BED assay was developed to estimate the proportion of recent HIV infections in a population. We used the BED assay as a proxy for acute infection to quantify the associated risk of mother-to-child-transmission (MTCT) during pregnancy and delivery. Design A total of 3773 HIV-1 sero-positive women were test...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章
doi:10.1093/ije/dyr055
更新日期:2011-08-01 00:00:00
abstract::To describe secular trends in pneumonia hospitalizations in the Bronx, New York City from 1982-1986, we analysed all cases with a discharge diagnosis of pneumonia, excluding Pneumocystis carinii pneumonia (PCP), for Bronx residents by age, sex, neighbourhood, and length of stay (N = 21,822). Hospital deaths from PCP a...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.4.926
更新日期:1989-12-01 00:00:00
abstract::The total duration of 'ovulatory activity' or 'ovulatory age' has been reported to be the strongest indicator of the risk of ovarian cancer. In the case-control study examined in this paper this variable was found to be a strong correlate of the risk of ovarian cancer. However, the finding that in older women the majo...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/12.2.161
更新日期:1983-06-01 00:00:00
abstract::In September 1665, an outbreak of plague occurred in Eyam, a small village 10 miles west of Sheffield, in an isolated valley of Derbyshire. Eighty per cent of the population died during the 14 months of the epidemic, a greater proportion than any other community in England. When plague threatened to cause panic and de...
journal_title:International journal of epidemiology
pub_type: 历史文章,杂志文章
doi:10.1093/ije/15.3.379
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:In July 2004 a strain-specific vaccine was introduced to combat an epidemic of group B meningococcal disease in New Zealand. We estimated the effectiveness of this vaccine in pre-school-aged children. METHODS:We conducted a cohort analysis of all children in New Zealand who were aged 6 months to <5 years at...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyn228
更新日期:2009-04-01 00:00:00
abstract::A questionnaire survey was administered in January 1982 to 3090 junior high school boys and girls in Nagoya, Japan. The proportion of current regular smokers who smoke at least one cigarette per week was 3.6% for boys and 0.5% for girls. By the third grade this had increased to 6.9% and 1.2% respectively for each sex....
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.4.814
更新日期:1988-12-01 00:00:00
abstract::In view of the many changes in the approach to the detection and management of hypertension that have occurred, the paucity of current data on this subject in Israel limits the possibilities of making international comparisons or evaluating trends. This study contributes recent information on the occupationally-active...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.4.676
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Aetiological profiles of non-Hodgkin's lymphoma (NHL) may differ depending upon whether the disease is inheritance-related or sporadic. Because familial risk (a probable surrogate of inheritance-relatedness) of NHL is influenced by haematolymphoproliferative malignancies (HLPM), we evaluated whether non-fami...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.4.818
更新日期:2001-08-01 00:00:00
abstract:Background:An increasing number of original studies suggest that exposure to shift work could be associated with the risk of overweight and obesity, but the results remain conflicted and inconclusive. This study aimed to quantitatively synthesize available epidemiological evidence on the association between shift work ...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析
doi:10.1093/ije/dyy079
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:This study evaluated whether food insecurity and obesity were associated in a population sample in Trinidad. METHODS:A sample was drawn of 15 clusters of households, in north central Trinidad. Resident adults were enumerated. A questionnaire was administered including the short form Household Food Security ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyg100
更新日期:2003-08-01 00:00:00
abstract:Background:Mendelian randomization (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association studies (GWAS) allows straightforward application of MR using summary data metho...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx102
更新日期:2017-12-01 00:00:00
abstract::In this paper we examine the effects on life expectancy of elimination of 4 major causes of death. Methodologically, we compare the results of cause elimination under assumptions of pattern of failure elimination and assumptions of underlying cause elimination in a modified multiple-decrement life table framework for ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/9.2.111
更新日期:1980-06-01 00:00:00
abstract::Socioeconomic conditions are important in explaining variation in cardiovascular morbidity in advanced societies. To analyse whether cardiovascular risk factors vary according to socioeconomic status in a developing country, and more specifically, in an urban area of China, we compared data from structured interviews ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.4.905
更新日期:1990-12-01 00:00:00
abstract::Cardiovascular disease risk factor and mortality data collected since the 1978 Conference on the Decline in Coronary Heart Disease Mortality were reviewed. Risk factor and disease trends were generally parallel and compatible with current hypotheses of cause and prevention. A few discrepancies between risk factors and...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Although several public health organizations have recommended population-wide reduction in salt intake, the evidence on the population benefits remains unclear. We conducted a metaknowledge analysis of the literature on salt intake and health outcomes. METHODS:We identified reports--primary studies, systema...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/dyv184
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Despite reporting lower levels of alcohol consumption, people with lower socio-economic status (SES) experience greater alcohol-related harm. Whether differential biases in the measurement of alcohol use could explain this apparent paradox is unknown. Using alcohol biomarkers to account for measurement error...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa113
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND:Breast cancer is the most frequent cancer in women and the incidence has increased over time. Our objectives were to study: (1) the socioeconomic differences in breast cancer incidence and mortality in Denmark, (2) how different socioeconomic groups have contributed to the increasing incidence, (3) whether t...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyg049
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Little is known about the relationship between physical functional health and long-term risk of coronary heart disease (CHD) independently of known risk factors in a general population. METHODS:Men and women aged 40-79 years at baseline who completed a health and lifestyle questionnaire and attended a healt...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyq061
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The excess risk of fatal and non-fatal cerebrovascular disease in people from low socioeconomic positions is only partially explained by conventional cerebrovascular risk factors. This has led to the suggestion that poor psychosocial work environments provide important additional explanatory power. However, ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyn373
更新日期:2009-10-01 00:00:00
abstract::In this paper, a new non-parametric competing-risk model is proposed. This model takes relative susceptibility into account, and is thus free from the usual assumption of independence between competing causes of death. Another feature of the model is the adjustments of survivors and deaths as a results of the eliminat...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/6.2.153
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND:Recently, using a counterfactual framework, a causal mediation analysis has been formalized to decompose the total effect of a time-fixed exposure on an outcome into four components that can be loosely defined as being components due to mediation only, interaction only, mediated interaction and neither. The ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy252
更新日期:2019-08-01 00:00:00
abstract::The effect of misclassification by one-, two-, or seven-day food records on the apparent magnitude of results was quantified for two hypothetical models of association of diet with disease. For each of 106 women, classification to quintiles of intake was calculated from 37 to 72 one-day records and compared to classif...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.1.232
更新日期:1989-03-01 00:00:00
abstract::Aboriginal communities have a high prevalence of upper and lower respiratory tract disease. One thousand two hundred and eighty seven West Australian Aborigines and 265 non-Aborigines were examined. Twenty nine per cent of Aborigines had lower respiratory tract abnormalities. Amongst 635 Aboriginal children less than ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/12.1.105
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:The scale of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among health care workers (HCWs), particularly in resource-limited settings, remains unclear. To address this concern, universal (non-symptom-based) screening of HCWs was piloted to determine the proportion of SARS-CoV-2 infe...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa173
更新日期:2020-10-23 00:00:00
abstract::Workers in the corn wet-milling industry are exposed to grain dusts, pesticides and fumigants, acids, solvents, sulphur dioxide, and other chemicals used in the manufacture of starch, oil, syrup, and dextrins. In a preliminary investigation of the long-term health effects of occupational exposures in this industry, de...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.3.432
更新日期:1985-09-01 00:00:00
abstract::We present two enhancements to existing methods for visualizing vital statistics data. Data from the Human Mortality Database were used and vital statistics from England and Wales are used for illustration. The simpler of these methods involves coplotting mean age of death with its variance, and the more complex of th...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt115
更新日期:2013-08-01 00:00:00
abstract::In an effort to search for causes of malnutrition in the urban environment to guide intervention efforts, a study of more than 2000 mother/child pairs was conducted in Kinshasa, Zaire. Under the auspices of the Zairian National Nutrition Planning Center a representative sample of a large lower class urban population w...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.3.556
更新日期:1988-09-01 00:00:00
abstract:Background:Existing studies of the 1944-45 Dutch famine found little evidence of the association between early life malnutrition and midlife cognition. Methods:Among 2446 rural participants born between 1958 and 1963 in the China Health and Retirement Longitudinal Study, we examined effects of exposure to China's 1959...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx222
更新日期:2018-02-01 00:00:00