Abstract:
BACKGROUND:We conducted this combined analysis of available data from studies with information on this issue to clarify the association between Trichomonas vaginalis infection and cervical neoplasia. METHODS:We performed MEDLINE searches (1966-1993) using the key words and phrases 'trichomonas vaginitis' and 'neoplasms, cervix' for articles published in English, and searched citations of the articles obtained from MEDLINE: A total of 24 articles (two cohort studies and 22 case-control) were included in this data analysis. In the analysis, the studies were evaluated for heterogeneity using Breslow-Day tests for homogeneity of the odds ratios and of rate ratios. If the odds ratios from studies are heterogeneous, it is not appropriate to combine them using the Mantel-Haenszel method. Also, publication bias was evaluated by assessing the association between the observed effect size and the variance of the effect size using a rank correlation test. RESULTS:The combined summary relative risk for the two cohort studies was 1.93 (95% confidence interval: 1.22-2.65) indicating an approximate doubling of the risk of cervical neoplasia in the presence of T. vaginalis infection. The attributable risks among exposed subjects and among the source population were 47.4% and 2.1% respectively. Results of the 22 retrospective studies were much less consistent. However, most of them demonstrated a significant positive association. CONCLUSIONS:This combined analysis suggests that there is an association between T. vaginalis and the risk of cervical neoplasia, but that such infections account for only 2% of cervical neoplasia.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Zhang ZF,Begg CBdoi
10.1093/ije/23.4.682subject
Has Abstractpub_date
1994-08-01 00:00:00pages
682-90issue
4eissn
0300-5771issn
1464-3685journal_volume
23pub_type
杂志文章,meta分析abstract::A continuum of reproductive causality is postulated, extending from fetal deaths - abortion, stillbirth, and neonatal - through a descending gradient of brain damage manifested in neuropsychiatric disorders. The research and administrative public health implications of these findings and the concept of the continuum a...
journal_title:International journal of epidemiology
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-09-01 00:00:00
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更新日期:1993-02-01 00:00:00
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更新日期:1992-02-01 00:00:00
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更新日期:1985-12-01 00:00:00
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更新日期:2011-06-01 00:00:00
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更新日期:2003-08-01 00:00:00
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更新日期:1996-10-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1998-12-01 00:00:00
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更新日期:1990-12-01 00:00:00
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更新日期:2005-04-01 00:00:00
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更新日期:1997-04-01 00:00:00
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更新日期:1996-08-01 00:00:00
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更新日期:1980-03-01 00:00:00