Abstract:
BACKGROUND:The objective of this retrospective cohort study was to assess the effect of hysterectomy on subsequent risk of cancer among 25,382 hysterectomized and a similar number of non-hysterectomized control women, registered in 1963-1976 in the Mass Screening Registry (MSR). METHODS:Cancer cases were obtained from the Finnish Cancer Registry (FCR) and standardized incidence ratio (SIR); the expected number of cases based on cancer incidence rates of the Finnish female population in 1967-1993, was used. Relative risk (RR) was calculated as SIR among the hysterectomized relative to non-hysterectomized women, adjusted for follow-up, education and parity. RESULTS:The RR estimates of non-genital cancers among women with any hysterectomy were approximately 5% higher than in the non-hysterectomized cohort. Relative risks of rectal cancer (RR = 1.4, 95% confidence interval [CI]: 1.0-1.8) and thyroid cancer (RR = 2.1, 95% CI; 1.5-3.1) were significant and largest among women who had undergone total hysterectomy pre- or perimenopausally. Relative risk estimates of breast cancer were close to unity. CONCLUSIONS:Hysterectomy is not associated with any substantial protective or promoting effect on cancers in general. Elevated risk of papillary thyroid cancer following hysterectomy is biologically plausible, as there are reproductive and endocrinological causes of thyroid cancer.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Luoto R,Auvinen A,Pukkala E,Hakama Mdoi
10.1093/ije/26.3.476subject
Has Abstractpub_date
1997-06-01 00:00:00pages
476-83issue
3eissn
0300-5771issn
1464-3685journal_volume
26pub_type
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journal_title:International journal of epidemiology
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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更新日期:1993-12-01 00:00:00
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更新日期:2009-06-01 00:00:00
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更新日期:2019-02-01 00:00:00
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更新日期:2002-12-01 00:00:00
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更新日期:2015-06-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:2000-12-01 00:00:00
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更新日期:2017-08-01 00:00:00
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更新日期:1997-12-01 00:00:00
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更新日期:2014-04-01 00:00:00
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更新日期:1998-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2008-04-01 00:00:00
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更新日期:1988-03-01 00:00:00
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更新日期:2015-08-01 00:00:00