Abstract:
BACKGROUND:Recent studies indicate that cancers of the salivary gland are increasing, and the factors responsible for the increase are unknown. Artefactual changes, such as shift in classifying cancers of the floor of the mouth to cancers of the salivary gland, could affect the time trend for salivary gland cancer. METHODS:The current study examined the time trends for cancers of the salivary gland and for cancers of the floor of the mouth and lower gum by using Connecticut Tumor Registry data for the time period 1935-1992. A regression model was used to identify the components of birth cohort, period and age as determinants of the observed time trend. RESULTS:Cancers of the salivary gland have recently increased in Connecticut, with a relative risk of 1.48 (95% CI: 1.06-2.08) for females in 1990-1992 compared to 1980-1984, and a comparable relative risk of 1.60 (95% CI: 1.16-2.22) for males. The increase was found in all age groups 40 and over, particularly among those aged 70 and over. The results from age-period-cohort modelling show a recent upturn in the trend for period slopes, with no clear increase from recent birth cohorts, which is consistent with the results from univariate analyses suggesting no clear increase among those under 40 years of age. CONCLUSION:Our results suggest that artifactual changes, such as a shift in designation of cancer sites, increasing use of the needle aspirate biopsies, and greater access to medical care for the elderly, may have largely contributed to the rising trend. The known risk factors, radiation exposure and a history of a prior cancer, can hardly explain the observed increase. The Epstein-Barr virus infection has only been associated with certain types of rare squamous cell carcinomas of the salivary gland in the Eskimo population. The AIDS epidemic also cannot explain why older age groups have accounted for most of the increase in incidence of the disease. An examination of the incidence rates for cancers of the salivary gland from other populations may help to clarify the issue.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Zheng T,Holford TR,Chen Y,Ward B,Liu W,Flannery J,Boyle Pdoi
10.1093/ije/26.2.264subject
Has Abstractpub_date
1997-04-01 00:00:00pages
264-71issue
2eissn
0300-5771issn
1464-3685journal_volume
26pub_type
杂志文章abstract::Mortality among male employees was studied in a chromium chemical production plant, part of which was rebuilt in 1950-51 and the remainder in 1960, to reduce exposure to chromium bearing dusts. Of 2 101 employees initially employed between 1945 and 1974 and having worked at least 90 days, the vital status of 88% was a...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/8.4.365
更新日期:1979-12-01 00:00:00
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journal_title:International journal of epidemiology
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pub_type: 杂志文章
doi:10.1093/ije/20.3.736
更新日期:1991-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:1991-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of epidemiology
pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-12-01 00:00:00
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更新日期:1998-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-12-01 00:00:00
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更新日期:2007-10-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.4.905
更新日期:1990-12-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
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更新日期:2006-08-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.4.730
更新日期:1995-08-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/ije/dyy264
更新日期:2019-06-01 00:00:00