Abstract:
MOTIVATION:RVPedigree (Rare Variant association tests in Pedigrees) implements a suite of programs facilitating genome-wide analysis of association between a quantitative trait and autosomal region-based genetic variation. The main features here are the ability to appropriately test for association of rare variants with non-normally distributed quantitative traits, and also to appropriately adjust for related individuals, either from families or from population structure and cryptic relatedness. IMPLEMENTATION:RVPedigree is available as an R package. GENERAL FEATURES:The package includes calculation of kinship matrices, various options for coping with non-normality, three different ways of estimating statistical significance incorporating triaging to enable efficient use of the most computationally-intensive calculations, and a parallelization option for genome-wide analysis. AVAILABILITY:The software is available from the Comprehensive R Archive Network [CRAN.R-project.org] under the name 'RVPedigree' and at [https://github.com/GreenwoodLab]. It has been published under General Public License (GPL) version 3 or newer.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Oualkacha K,Lakhal-Chaieb L,Greenwood CMdoi
10.1093/ije/dyw047subject
Has Abstractpub_date
2016-04-01 00:00:00pages
402-7issue
2eissn
0300-5771issn
1464-3685pii
dyw047journal_volume
45pub_type
杂志文章abstract:BACKGROUND:Although several public health organizations have recommended population-wide reduction in salt intake, the evidence on the population benefits remains unclear. We conducted a metaknowledge analysis of the literature on salt intake and health outcomes. METHODS:We identified reports--primary studies, systema...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/dyv184
更新日期:2016-02-01 00:00:00
abstract:Background:We previously showed that low-dose computed tomography (LDCT) screening in asbestos-exposed workers is effective in detecting lung cancer (LC) at an early stage. Here, we evaluate whether LDCT screening could reduce mortality from LC in such a high-risk population. Methods:Within a cohort of 2433 asbestos-e...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy212
更新日期:2018-12-01 00:00:00
abstract::In this paper, a new non-parametric competing-risk model is proposed. This model takes relative susceptibility into account, and is thus free from the usual assumption of independence between competing causes of death. Another feature of the model is the adjustments of survivors and deaths as a results of the eliminat...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/6.2.153
更新日期:1977-06-01 00:00:00
abstract::It is a long-standing belief that the size of the difference between the poor (lower social groups) and the rich (higher social groups) in health outcomes will vary according to the characteristics of the area. However typical approaches to analyses of this kind of question violate standard statistical assumption. The...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.1.251
更新日期:1991-03-01 00:00:00
abstract::Blood samples from 382 children between the ages of one and 15 years were tested for anti-chlamydial antibody. A low prevalence of antibody against Chlamydia trachomatis was found among children under the age of seven years. Antibody against the Chlamydial agent C IOL-207 was rare before the age of five years, but was...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/13.4.491
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Life history theory and resource dilution models of the family suggest that siblings may present a threat to healthy development because they compete for resources that parents have available to invest in individual offspring. Using data from a large cohort study of contemporary British families (ALSPAC), we...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyn116
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Mycobacterium leprae (M. leprae) soluble antigen (MLSA) reagents have been developed with the aim of finding a reagent, comparable to tuberculin, which could identify individuals infected with the leprosy bacillus. They have yet to be evaluated fully in human populations. METHODS:More than 15000 individuals...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.4.713
更新日期:1998-08-01 00:00:00
abstract::The immune adherence haemagglutination assay (IAHA), widely used for human viral disease diagnosis, has been adapted for detection of rabies virus antibodies in dog sera. Rabies virus antibody titres obtained by the IAHA correlated well with those obtained by the currently accepted test for rabies antibody determinati...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.3.472
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:The scale of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among health care workers (HCWs), particularly in resource-limited settings, remains unclear. To address this concern, universal (non-symptom-based) screening of HCWs was piloted to determine the proportion of SARS-CoV-2 infe...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa173
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:This article analyses the epidemiological research developments in Latin America and the Caribbean (LAC). It integrates the series commissioned by the International Epidemiological Association to all WHO Regions to identify global opportunities to promote the development of epidemiology. METHODS:Health situ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys017
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:The aims of this study were to examine the prevalence of drug use, and how morbidity, use of health services, self-evaluated health, demographic pattern and lifestyle characteristics influence drug use in a general population. METHODS:The study was carried out in the municipality of Tromsø, Norway. A sample...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.6.1262
更新日期:1994-12-01 00:00:00
abstract::Studies of diet in relation to disease raise methodological challenges considerably more complicated than in most epidemiological investigations. Diet is not a single exposure, but rather a complex set of many intercorrelated continuous variables. Moreover, these variables are likely to have non-linear relationships w...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.2.312
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Childhood mortality is a major public health problem in sub-Saharan Africa. For the implementation of efficient public health systems, knowledge of the spatial distribution of mortality is required. METHODS:Data from a demographic surveillance research project were analysed which comprised information obtai...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.3.485
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Child feeding recommendations include breastfeeding beyond 12 months, however, some researchers have reported increased rates of malnutrition in breastfed toddlers. A negative association between growth and breast-feeding may reflect reverse causality; that is, the outcome (growth) is a determinant of the pr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.2.349
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:The long-term effects of infant vitamin D supplementation and status are unclear since there have been few controlled intervention trials and these have been small and contradictory. The Delhi Infant Vitamin D Supplementation (DIVIDS) trial found that supplementation of low-birthweight term infants with one ...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyv116
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:The relationship between income and health is usually thought to be curvilinear, but previous studies have yielded inconsistent results. We therefore examined the shape of the relationship between household equivalent income and self-assessed health in seven European countries. METHODS:Data were obtained fr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh338
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Few studies have examined the independent and combined relationships of body mass index (BMI) peak and rebound with adiposity, insulin resistance and metabolic risk later in life. We used data from Project Viva, a well-characterized birth cohort from Boston with repeated measures of BMI, to help fill this ga...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy286
更新日期:2019-02-01 00:00:00
abstract::The prevalence of diabetes, the interrelationship of blood glucose, serum insulin, and lipids, and their relationship to ischemic heart dise ase in a rural Jamaican community were investigated. The people were mo stly of West African descent. Occupations were primarily agricultural w ith much physical labor. Approx...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/1.2.157
更新日期:1972-07-01 00:00:00
abstract:OBJECTIVES:To examine educational gradients in overall and cause-specific mortality among elderly married men and women and their spouses. METHODS:Using the census-based Israel Longitudinal Mortality Study (1983-92), 13 573 married men and 6563 married women were identified who were aged 70-89 years at baseline. Cox p...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyi185
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:There is considerable interest in estimating the causal effect of a range of maternal environmental exposures on offspring health-related outcomes. Previous attempts to do this using Mendelian randomization methodologies have been hampered by the paucity of epidemiological cohorts with large numbers of genot...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyz019
更新日期:2019-06-01 00:00:00
abstract::In this study, we derive national estimates of the prevalence of children's exposure to parental smoking in West Germany. The estimates are based on a national health survey conducted in 1987 and refer to those parents living in the same household as the child. Estimated prevalences of maternal smoking range from 18.9...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.5.818
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:In 2002, a poster alerted the French health authorities to the possibility that the risk of childhood leukaemia might be increased by hepatitis B vaccination. Elucidating the role of vaccination in the aetiology of childhood acute leukaemia (AL) was therefore included in the objectives of an ongoing national...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyl270
更新日期:2007-02-01 00:00:00
abstract::Aetiology confronts two distinct issues: the determinants of individual cases, and the determinants of incidence rate. If exposure to a necessary agent is homogeneous within a population, then case/control and cohort methods will fail to detect it: they will only identify markers of susceptibility. The corresponding s...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.1.32
更新日期:1985-03-01 00:00:00
abstract::A matched case-control study among cervical cancer patients in Denmark was conducted to evaluate the possible influence of radiation therapy on leukaemia risk. Among 25718 women treated between 1943-1977, 27 cases of leukaemia occurred one or more years after diagnosis. Four controls were matched to each case on age, ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.3.363
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:International rankings of infant mortality rates have been consistently lower for the US than other industrialized countries, and this ranking has been falling. This study examines the influence of birth registrations among very low birthweight infants on these international rankings. METHODS:Birth rates of...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.3.583
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:In the past, upward shifts of the so-called Preston curve, which relates life expectancy to national income, have contributed importantly to worldwide increases in life expectancy. These shifts were due to rapid diffusion of knowledge and technology for infectious disease control from high-income to low-inco...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt122
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Despite abundant evidence that lower education is associated with a higher risk of smoking, whether the association is causal has not been convincingly established. METHODS:We investigated the association between education and lifetime smoking patterns in a birth cohort established in 1959 and followed thro...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dym250
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Maternal co-infection with human immunodeficiency virus (HIV) has been implicated as a potentially important co-factor for enhanced vertical transmission of hepatitis C virus (HCV). In previous reports, however, methodological issues (notably small sample sizes) have limited accurate evaluation of the contri...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyg107
更新日期:2003-10-01 00:00:00
abstract::This study presents data on cancer incidence among 37,795 blood donors in an attempt to test the hypothesis that blood donation might be associated with cancer development. At a median follow-up time of nine years (range 5-13 years) a total of 1152 cancer cases have been diagnosed. The expected number of cancer cases ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.3.505
更新日期:1990-09-01 00:00:00
abstract::Biological interference among viral agents might have significant implications for disease prevention and therapy. Field data for influenza yield conflicting evidence concerning the independence of infection rates, or disease severity, for two co-circulating viruses. To examine the effects of several assumed modes of ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.2.444
更新日期:1990-06-01 00:00:00