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Seasonal variation in cause-specific mortality: are there high-risk groups? 25-year follow-up of civil servants from the first Whitehall study.

Abstract：

OBJECTIVES:To determine the seasonal effect on all-cause and cause-specific mortality and to identify high-risk groups. METHODS:A 25-year follow-up of 19,019 male civil servants aged 40-69 years. RESULTS:All-cause mortality was seasonal (ratio of highest mortality rate during winter versus lowest rate during summer 1.22, 95% CI : 1.1-1.3), largely due to the seasonal nature of ischaemic heart disease. Participants at high risk based on age, employment grade, blood pressure, cholesterol, forced expiratory volume, smoking and diabetes did not have higher seasonal mortality, although participants with ischaemic heart disease at baseline did have a higher seasonality effect (1.38, 95% CI : 1.2-1.6) than those without (1.18, 95% CI : 1.1-1.3) (P = 0.03). CONCLUSIONS:Seasonal mortality differences were greater among those with prevalent ischaemic heart disease and at older ages, but were not greater in individuals of lower socioeconomic status or with a high multivariate risk score. Since seasonal differences showed no evidence of declining over time, elucidating their causes and preventive strategies remains a public health challenge.

journal_name

Int J Epidemiol

journal_title

International journal of epidemiology

authors

van Rossum CT,Shipley MJ,Hemingway H,Grobbee DE,Mackenbach JP,Marmot MG

doi

10.1093/ije/30.5.1109

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

1109-16

issue

5

eissn

0300-5771

issn

1464-3685

journal_volume

30

pub_type

杂志文章

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