Abstract:
:The European Atherosclerosis Research Study--EARS--is a multicentre collaborative project sponsored by the European Community. Its main objective is to study, in young people, the biological expression of a paternal history of premature acute myocardial infarction (AMI) and the relative share of heredity and environment in this expression. In 14 centres in 11 European countries, the offspring of fathers who suffered from a documented AMI before the age of 55 years (cases) are compared with age- and sex-matched control individuals. Genetic variables (restriction fragment length polymorphisms of candidate genes), lifestyle variables and biochemical variables that are known or suspected to play a role in the development of coronary heart disease (CHD), are studied. The cultural and ethnic diversity within Europe allows a thorough investigation of the relative importance and the potential interactions of genetics and environment in the pathogenesis of CHD. A standardized core methodology and centralized storage of blood samples with particular types of analyses systematically carried out in one or a few specialized laboratories, from a strong basis for valid cross-cultural analyses. The results of this study will offer new clues for the modelling of individual risk for developing CHD.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
doi
10.1093/ije/23.3.465subject
Has Abstractpub_date
1994-06-01 00:00:00pages
465-71issue
3eissn
0300-5771issn
1464-3685journal_volume
23pub_type
杂志文章,多中心研究abstract::Prospective data from the Matlab surveillance area in rural Bangladesh, 1974-1982, were used in this study to show that divorced and never-married adults (aged 15-44 years) had significantly higher mortality than their currently married peers with differences in disability status accounting for some of this excess ris...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.3.445
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:This study aims to evaluate the contribution of the reduction in major cardiovascular diseases (CVD), malignant neoplasms (MN), accidents and AIDS mortality to the gains in life expectancy observed during the decade 1985-1994, as well as to calculate and compare the potential gains due to the partial or tota...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/28.5.905
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:The long-term effects of infant vitamin D supplementation and status are unclear since there have been few controlled intervention trials and these have been small and contradictory. The Delhi Infant Vitamin D Supplementation (DIVIDS) trial found that supplementation of low-birthweight term infants with one ...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyv116
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:If several risk factors for disease are considered in a regression model and these factors are affected by measurement errors, the observed relative risk will be attenuated. In nutritional epidemiology, several nutrient variables show strong correlation, described as collinearity. The observed relative risk ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.5.1071
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Increasing life expectancy has brought public health concern about the increase in prevalence of disability in old age. Reducing the prevalence of disability in older age requires the identification of preventable or modifiable risk factors earlier in life. We have examined the relationship between lifestyle...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Epidemiological inferences about the aetiology of a disease can often be made from its seasonal patterns. However, due to its multifactorial nature, the seasonality component can be obscured by other factors. It is therefore important to develop statistical techniques which are sensitive to minute temporal c...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.2.426
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Cholesterol levels in many Asian countries are rising. Predictions of the likely effects of this on the incidence of cardiovascular diseases have mostly relied on data from Western populations. Whether the associations between total cholesterol and cardiovascular diseases are similar in Asia is not establish...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析
doi:10.1093/ije/dyg106
更新日期:2003-08-01 00:00:00
abstract:Background:The Obstetrics and Periodontal Therapy (OPT) study, a randomized controlled trial, reported no effect of periodontal treatment on preterm birth. Even though there were more spontaneous abortions or stillbirths in the control group, sensitivity analyses using conventional approaches did not change the results...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyy089
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Longitudinal cohort studies in sub-Saharan Africa are urgently needed to understand cardiovascular disease development. We, therefore, explored health behaviours and conventional risk factors of African individuals with optimal blood pressure (BP) (≤ 120/80 mm Hg), and their 5-year prediction for the develop...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys106
更新日期:2012-08-01 00:00:00
abstract::Operational research (OR) analysis provides information and systems to support decision making. In health care there are examples of OR being used to support decisions surrounding both the organization of health services and the treatment of individual patients. However, its uptake is currently low in spite of the inc...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.supplement_1.s90
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Mycobacterium leprae (M. leprae) soluble antigen (MLSA) reagents have been developed with the aim of finding a reagent, comparable to tuberculin, which could identify individuals infected with the leprosy bacillus. They have yet to be evaluated fully in human populations. METHODS:More than 15000 individuals...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.4.713
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:The health benefits of physical activity are well established, but the overall amount of physical activity associated with cardiovascular and other health outcomes, and whether the relationships are similar in men and women and at different ages is still debated. This may be partly related to different metho...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyl079
更新日期:2006-08-01 00:00:00
abstract:AIM AND METHODS:To discuss evidence for and against genetic 'causes' of type 2 diabetes, illustrated by standardized study of glucose intolerance and high blood pressure in four representative African origin populations. Comparison of two genetically closer sites: rural (site 1) and urban Cameroon (2); then Jamaica (3)...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.1.111
更新日期:2001-02-01 00:00:00
abstract::The immune adherence haemagglutination assay (IAHA), widely used for human viral disease diagnosis, has been adapted for detection of rabies virus antibodies in dog sera. Rabies virus antibody titres obtained by the IAHA correlated well with those obtained by the currently accepted test for rabies antibody determinati...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.3.472
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:The BED assay was developed to estimate the proportion of recent HIV infections in a population. We used the BED assay as a proxy for acute infection to quantify the associated risk of mother-to-child-transmission (MTCT) during pregnancy and delivery. Design A total of 3773 HIV-1 sero-positive women were test...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章
doi:10.1093/ije/dyr055
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:In designing prevention strategies, it may be useful to understand how early and midlife cardiovascular disease risk factor (CVDRF) exposures affect outcomes that primarily occur in mid to late life. Few single US cohorts have followed participants from early adulthood to late life. METHODS:We pooled four p...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy264
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Maternal co-infection with human immunodeficiency virus (HIV) has been implicated as a potentially important co-factor for enhanced vertical transmission of hepatitis C virus (HCV). In previous reports, however, methodological issues (notably small sample sizes) have limited accurate evaluation of the contri...
journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyg107
更新日期:2003-10-01 00:00:00
abstract::Aetiology confronts two distinct issues: the determinants of individual cases, and the determinants of incidence rate. If exposure to a necessary agent is homogeneous within a population, then case/control and cohort methods will fail to detect it: they will only identify markers of susceptibility. The corresponding s...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.1.32
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:Preliminary research suggests an association between depression and subsequent increased risk of infections, yet little is known on this topic. This study investigated the association between depression and risk of various types of infections, including temporal and dose-response relationships. METHODS:A pr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyv333
更新日期:2016-02-01 00:00:00
abstract::An outbreak of typhoid fever occurred in Chu-Tung township, Taiwan, with dates of onset from 6 July to 8 August, 1983. Fifty-four cases were hospitalized, of which 52 were laboratory confirmed. A chloramphenicol-resistant strain of Salmonella typhi was isolated from patients' blood samples. A community survey of 2772 ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.1.254
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:We assessed the differential and sequential effects of a Government of India conditional cash transfer scheme for the socio-economically disadvantaged (Janani Suraksha Yojana; JSY) and the strengthening of the primary health centre (PHC) network to provide 24/7 obstetric care in promoting institutional deliv...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt071
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Bundling, which consists of wrapping an infant for prolonged periods in a sheepskin cover after dried cow dung is applied, is a common and apparently unique practice limited to the rural, mountainous regions of Northern Pakistan. The practice is initiated at various ages during the neonatal period. Its poten...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.4.879
更新日期:1996-08-01 00:00:00
abstract::Kersa HDSS was established in 12 sub-districts of Kersa district, Eastern Hararge, Oromia Region, Ethiopia. The site is principally rural with two small towns (Kersa and Weter). The baseline census was conducted in 2007 and since then has been updated every 6 months, with registration of demographic and health events....
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyv284
更新日期:2016-02-01 00:00:00
abstract::A hospital-based case-control study of myocardial infarction in young women conducted in Belgrade from January 1983 to December 1986 is presented. A total of 58 women with infarction, aged 30 to 50 years were compared with 174 age-matched controls. Smoking of 15 or more cigarettes per day, diabetes, hypertension, angi...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.3.585
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:The genetic basis of several familial cancers including breast and colon cancers has been identified recently. The occurrence of multiple cancers in one individual is also suggestive of a genetic predisposition. To evaluate inherited predisposition in pancreatic cancer we compared the clinical data of pancre...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/29.6.999
更新日期:2000-12-01 00:00:00
abstract::In the Zutphen Study data were collected on occupation, smoking habits, blood pressure, serum cholesterol, height and weight of 856 men who were 40-59 years old in 1960. Between 1960 and 1985 detailed information was collected on mortality. The effect of socioeconomic status as indicated by occupation on 25-year morta...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.3.658
更新日期:1989-09-01 00:00:00
abstract::Data on T4 and TSH values derived from a voluntary screening programme of thyroid function in Belgium are presented. Significant differences in T4 values according to sex, maturity and birthplace are shown. ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/7.3.249
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:Exposure to respirable crystalline silica is suggested to increase the risk of autoimmune rheumatic diseases. We examined the association between respirable crystalline silica exposure and systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and small vessel vasculitis. METHODS:In a cohort...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa287
更新日期:2021-01-18 00:00:00
abstract:OBJECTIVES:To examine educational gradients in overall and cause-specific mortality among elderly married men and women and their spouses. METHODS:Using the census-based Israel Longitudinal Mortality Study (1983-92), 13 573 married men and 6563 married women were identified who were aged 70-89 years at baseline. Cox p...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyi185
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Extended breastfeeding is known to benefit the health of children in developing countries and despite widespread expectations of a decline in breastfeeding in these countries, it has been demonstrated that the incidence and duration of breastfeeding are in fact increasing many countries. METHODS:In this pap...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.1.94
更新日期:1996-02-01 00:00:00