Sibship structure and risk of infectious mononucleosis: a population-based cohort study.

Abstract:

BACKGROUND:Present understanding of increased risk of Epstein-Barr virus (EBV)-related infectious mononucleosis among children of low birth order or small sibships is mainly based on old and indirect evidence. Societal changes and methodological limitations of previous studies call for new data. METHODS:We used data from the Danish Civil Registration System and the Danish National Hospital Discharge Register to study incidence rates of inpatient hospitalizations for infectious mononucleosis before the age of 20 years in a cohort of 2,543,225 Danes born between 1971 and 2008, taking individual sibship structure into account. RESULTS:A total of 12,872 cases of infectious mononucleosis were observed during 35.3 million person-years of follow-up. Statistical modelling showed that increasing sibship size was associated with a reduced risk of infectious mononucleosis and that younger siblings conferred more protection from infectious mononucleosis than older siblings. In addition to this general association with younger and older siblings, children aged less than 4 years transiently increased their siblings’ infectious mononucleosis risk. Our results were confirmed in an independent sample of blood donors followed up retrospectively for self-reported infectious mononucleosis. CONCLUSIONS:Younger siblings, and to a lesser degree older siblings, seem to be important in the transmission of EBV within families. Apparently the dogma of low birth order in a sibship as being at the highest risk of infectious mononucleosis is no longer valid.

journal_name

Int J Epidemiol

authors

Rostgaard K,Nielsen TR,Wohlfahrt J,Ullum H,Pedersen O,Erikstrup C,Nielsen LP,Hjalgrim H

doi

10.1093/ije/dyu118

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1607-14

issue

5

eissn

0300-5771

issn

1464-3685

journal_volume

43

pub_type

杂志文章
  • Birthplace as a risk factor in motor neurone disease and Parkinson's disease.

    abstract::A proportional mortality study was conducted to determine if state of birth is a risk factor associated with motor neurone disease (MND) and Parkinson's disease (PD) using US death certificate information for 1981. State of birth was used as a surrogate variable for location of early childhood environment. A gradient ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/22.5.898

    authors: Betemps EJ,Buncher CR

    更新日期:1993-10-01 00:00:00

  • Is it possible to reduce AIDS deaths without reinforcing socioeconomic inequalities in health?

    abstract:BACKGROUND:The wide use of highly active antiretroviral therapy has led to an impressive improvement in AIDS survival after the mid-1990s in cities and countries with a high access to these medications. Notwithstanding its beneficial overall effect, antiretroviral therapy was also reported as a factor for the increase ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyi022

    authors: Antunes JL,Waldman EA,Borrell C

    更新日期:2005-06-01 00:00:00

  • A competing-risk model based on the life table procedure in epidemiological studies.

    abstract::In this paper, a new non-parametric competing-risk model is proposed. This model takes relative susceptibility into account, and is thus free from the usual assumption of independence between competing causes of death. Another feature of the model is the adjustments of survivors and deaths as a results of the eliminat...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/6.2.153

    authors: Wong O

    更新日期:1977-06-01 00:00:00

  • Transmission of hepatitis B virus infection in Ethiopia with emphasis on the importance of vertical transmission.

    abstract::This two-year controlled study was conducted to define the mode of transmission of hepatitis B infection in Ethiopia. Twenty-five of 500 (5%) expectant mothers were identified as HbsAg positive (Group A). A control group of 29 mothers negative for HBsAg (Group B) was randomly selected. These 54 mothers and their famil...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/17.4.874

    authors: Tsega E,Tsega M,Mengesha B,Nordenfelt E,Hansson BG,Lindberg J

    更新日期:1988-12-01 00:00:00

  • Measurement of the frequency and severity of childhood acute respiratory infections through household surveys in northern Ghana.

    abstract:BACKGROUND:Methodological issues in the design and interpretation of cross-sectional interview surveys of the prevalence of acute respiratory infections (ARI) were assessed among young children. METHODS:A cross-sectional survey was conducted in approximately 20,000 children in the north of Ghana. Approximately half we...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/23.3.608

    authors: Ross DA,Huttly SR,Dollimore N,Binka FN

    更新日期:1994-06-01 00:00:00

  • Neighbourhood deprivation and health: does it affect us all equally?

    abstract:BACKGROUND:Neighbourhood socioeconomic status (SES) may affect rich and poor residents differentially. Two models are proposed. Model 1: living in a non-deprived neighbourhood is better for health because better collective material and social resources are available. Model 2: being poor (rich) relative to the neighbour...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyg084

    authors: Stafford M,Marmot M

    更新日期:2003-06-01 00:00:00

  • Influence of heavy agricultural work during pregnancy on birthweight in northeast Brazil.

    abstract:BACKGROUND:Women in developing countries often continue their agricultural work during late pregnancy. Whether this adversely affects birthweight is not clear from previous studies as few controlled for confounding factors. This study seeks to clarify this issue. METHODS:This retrospective cohort study investigated 95...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/28.3.469

    authors: Lima M,Ismail S,Ashworth A,Morris SS

    更新日期:1999-06-01 00:00:00

  • Effect of outdoor and indoor nitrogen dioxide on respiratory symptoms in schoolchildren.

    abstract:BACKGROUND:Nitrogen dioxide (NO(2)), an oxidant gas that contaminates both outdoor and indoor air, is considered to be a potential risk factor for asthma. We investigated concurrently the effects of outdoor and indoor NO(2) on the prevalence and incidence of respiratory symptoms among children. METHODS:A cohort study ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/29.5.862

    authors: Shima M,Adachi M

    更新日期:2000-10-01 00:00:00

  • Epidemiology of legal abortion in Italy.

    abstract::The paper reports on the trends of induced abortion in Italy since its legalization in 1978. Data collected through the national surveillance system show that the abortion rates and ratios in Italy, after an initial increase, have been stable in the last four years, and are comparable to those of other European countr...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/15.3.343

    authors: Figà-Talamanca I,Grandolfo ME,Spinelli A

    更新日期:1986-09-01 00:00:00

  • Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight.

    abstract:BACKGROUND:Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is causal. METHODS:We performed two-sample Mendelian randomization (MR) using summary data on associati...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyaa256

    authors: Moen GH,Beaumont RN,Grarup N,Sommer C,Shields BM,Lawlor DA,Freathy RM,Evans DM,Warrington NM

    更新日期:2020-12-21 00:00:00

  • An example of medical audit under political pressure.

    abstract::Management of medical services necessitates decisions regarding the possibly ineffective treatment programmes, hospitals and (even) individual practitioners. Although rigorous evaluations of effectiveness can only be achieved by randomized trials there has been, in recent years, much increase in audit (or peer review)...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/12.4.482

    authors: West RR,Willis JD

    更新日期:1983-12-01 00:00:00

  • Measles transmission in health facilities during outbreaks.

    abstract:BACKGROUND:Consultation waiting rooms and similar medical settings, either public or private, are places where children have higher probability of acquiring some infectious diseases, especially during outbreaks. METHODS:During a measles outbreak which occurred in Lisbon in 1989 a case-control study was carried out in ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/23.4.843

    authors: Miranda AC,Falcão J,Dias JA,Nóbrega SD,Rebelo MJ,Pimenta ZP,Saúde MD

    更新日期:1994-08-01 00:00:00

  • Epidemiology for prevention.

    abstract::This paper illustrates the basis of, expectations for and evaluation of prevention from an epidemiological perspective. Specifically, the extent to which epidemiologists could and should be involved in designing and evaluating public health interventions is addressed. Changes in the view on disease causation and epide...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,评审

    doi:10.1093/ije/24.4.655

    authors: Wall S

    更新日期:1995-08-01 00:00:00

  • A randomized clinical trial to evaluate ready-made spectacles in an adult population in India.

    abstract:BACKGROUND:Ready-made spectacles (RMS) have advantages; however, visual performance and satisfaction has not been evaluated. METHODS:A 1-month, double-masked, randomized clinical trial comparing planned continued use and visual performance of RMS to Custom Spectacles (CS) in adults aged 18-45 years with > or =1 diopte...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ije/dyp384

    authors: Keay L,Gandhi M,Brady C,Ali FS,Mathur U,Munoz B,Friedman DS

    更新日期:2010-06-01 00:00:00

  • Second-hand smoke in mental healthcare settings: time to implement total smoke-free bans?

    abstract:BACKGROUND:Second-hand smoke is associated with adverse health effects. Many countries have extended smoke-free policies to public buildings and workplaces such as hospitals, but mental health units have usually been exempted from complete smoke-free bans. The objective of this study was to evaluate second-hand smoke l...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyt014

    authors: Ballbè M,Sureda X,Martínez-Sánchez JM,Saltó E,Gual A,Fernández E

    更新日期:2013-06-01 00:00:00

  • Measuring effectiveness in community randomized trials of HIV prevention.

    abstract:BACKGROUND:Complicated HIV transmission dynamics make it unclear how to design and interpret results from community-randomized controlled trials (CRCT) of interventions to prevent infection. METHODS:Mathematical modelling was used to investigate the effectiveness of interventions to prevent HIV transmission aimed at h...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dym232

    authors: Hallett TB,Garnett GP,Mupamberiyi Z,Gregson S

    更新日期:2008-02-01 00:00:00

  • Influence of maternal human immunodeficiency virus (HIV) co-infection on vertical transmission of hepatitis C virus (HCV): a meta-analysis.

    abstract:BACKGROUND:Maternal co-infection with human immunodeficiency virus (HIV) has been implicated as a potentially important co-factor for enhanced vertical transmission of hepatitis C virus (HCV). In previous reports, however, methodological issues (notably small sample sizes) have limited accurate evaluation of the contri...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/ije/dyg107

    authors: Pappalardo BL

    更新日期:2003-10-01 00:00:00

  • Tubal sterilization and risk of ovarian, endometrial and cervical cancer. A Danish population-based follow-up study of more than 65 000 sterilized women.

    abstract:BACKGROUND:On the basis of a population-based cohort, we assessed the cancer risk, focusing on gynaecological cancers and pre-malignant lesions, among women with a previous tubal sterilization. METHODS:Using the Danish Hospital Discharge Register we identified 65 232 women who had a tubal sterilization (1977-1993). Th...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyh046

    authors: Kjaer SK,Mellemkjaer L,Brinton LA,Johansen C,Gridley G,Olsen JH

    更新日期:2004-06-01 00:00:00

  • Low-dose aspirin use and endometrial cancer mortality-a Danish nationwide cohort study.

    abstract:BACKGROUND:Accumulating evidence suggests that aspirin use may improve survival in cancer patients, however, for endometrial cancer, epidemiological evidence is limited and results are equivocal. In a nationwide cohort study, we examined the association between post-diagnostic low-dose aspirin use and endometrial cance...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyz253

    authors: Sperling CD,Verdoodt F,Aalborg GL,Dehlendorff C,Friis S,Kjaer SK

    更新日期:2020-02-01 00:00:00

  • Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries.

    abstract:BACKGROUND:In many western countries an increase in incidence of adenocarcinoma of the oesophagus and/or gastric cardia have been reported. The aim of this study was to describe and compare trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in several areas of Europe, 1968-1995, using Eurocim (a...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ije/29.4.645

    authors: Botterweck AA,Schouten LJ,Volovics A,Dorant E,van Den Brandt PA

    更新日期:2000-08-01 00:00:00

  • Delayed-type hypersensitivity to Mycobacterium leprae soluble antigens as a test for infection with the leprosy bacillus.

    abstract:BACKGROUND:Mycobacterium leprae (M. leprae) soluble antigen (MLSA) reagents have been developed with the aim of finding a reagent, comparable to tuberculin, which could identify individuals infected with the leprosy bacillus. They have yet to be evaluated fully in human populations. METHODS:More than 15000 individuals...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/27.4.713

    authors: Sterne JA,Fine PE,Pönnighaus JM,Rees RJ,Chavula D

    更新日期:1998-08-01 00:00:00

  • An international case-control study of adult glioma and meningioma: the role of head trauma.

    abstract:BACKGROUND:Increased brain tumour risk after head trauma suggested by case reports and clinical series has been previously studied epidemiologically with mixed results. An international multicentre case-control study investigated the role of head trauma from injury or sports participation in adult brain tumour risk. M...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ije/27.4.579

    authors: Preston-Martin S,Pogoda JM,Schlehofer B,Blettner M,Howe GR,Ryan P,Menegoz F,Giles GG,Rodvall Y,Choi NW,Little J,Arslan A

    更新日期:1998-08-01 00:00:00

  • Dietary patterns and the risk of mortality: impact of cardiorespiratory fitness.

    abstract:BACKGROUND:While dietary patterns that are both predictive of chronic disease and mortality have been identified, the confounding effects of cardiorespiratory fitness have not been properly addressed. The primary objective was to assess the relation between dietary patterns with all-cause mortality, while controlling f...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyp191

    authors: Héroux M,Janssen I,Lam M,Lee DC,Hebert JR,Sui X,Blair SN

    更新日期:2010-02-01 00:00:00

  • Reproducibility and relative validity of an extensive semi-quantitative food frequency questionnaire using dietary records and biochemical markers among Greek schoolteachers.

    abstract:BACKGROUND:We evaluated the reproducibility and relative validity of a 190-item semi-quantitative food frequency questionnaire (FFQ) to be used in a large prospective study in the Athens area of Greece. METHODS:In all, 42 men and 38 women, aged 25-67 years, completed two self-administered semi-quantitative FFQ spaced ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/26.suppl_1.s118

    authors: Katsouyanni K,Rimm EB,Gnardellis C,Trichopoulos D,Polychronopoulos E,Trichopoulou A

    更新日期:1997-01-01 00:00:00

  • Towards a risk map of malaria for Sri Lanka: the importance of house location relative to vector breeding sites.

    abstract:BACKGROUND:In Sri Lanka, the major malaria vector Anopheles culicifacies breeds in pools formed in streams and river beds and it is likely that people living close to such breeding sites are at higher risk of malaria than people living further away. This study was done to quantify the importance of house location relat...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyg055

    authors: Van Der Hoek W,Konradsen F,Amerasinghe PH,Perera D,Piyaratne MK,Amerasinghe FP

    更新日期:2003-04-01 00:00:00

  • Excess mortality for the unmarried in rural Bangladesh.

    abstract::Prospective data from the Matlab surveillance area in rural Bangladesh, 1974-1982, were used in this study to show that divorced and never-married adults (aged 15-44 years) had significantly higher mortality than their currently married peers with differences in disability status accounting for some of this excess ris...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/22.3.445

    authors: Rahman O

    更新日期:1993-06-01 00:00:00

  • Exposure to perchlorate, nitrate and thiocyanate, and prevalence of diabetes mellitus.

    abstract:Background:It is known that perchlorate, nitrate and thiocyanate have the property of inhibiting sodium iodide symporter. Animal studies have suggested that these compounds, especially perchlorate, might also interfere with insulin secretion. However, the association between their exposure and diabetes risk is largely ...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyx188

    authors: Liu G,Zong G,Dhana K,Hu Y,Blount BC,Morel-Espinosa M,Sun Q

    更新日期:2017-12-01 00:00:00

  • A comparison of sisterhood information on causes of maternal death with the registration causes of maternal death in Matlab, Bangladesh.

    abstract:BACKGROUND:To explore whether causes of maternal death can be investigated using the sisterhood method, an indirect method for providing a community-based estimate of the level of maternal mortality, this study compares the sisterhood causes of maternal death with the Matlab Demographic Surveillance System's (DSS) caus...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/24.5.937

    authors: Shahidullah M

    更新日期:1995-10-01 00:00:00

  • Smoking among junior high school students in Nagoya, Japan.

    abstract::A questionnaire survey was administered in January 1982 to 3090 junior high school boys and girls in Nagoya, Japan. The proportion of current regular smokers who smoke at least one cigarette per week was 3.6% for boys and 0.5% for girls. By the third grade this had increased to 6.9% and 1.2% respectively for each sex....

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/17.4.814

    authors: Ogawa H,Tominaga S,Gellert G,Aoki K

    更新日期:1988-12-01 00:00:00

  • Life expectancy and national income in Europe, 1900-2008: an update of Preston's analysis.

    abstract:BACKGROUND:In the past, upward shifts of the so-called Preston curve, which relates life expectancy to national income, have contributed importantly to worldwide increases in life expectancy. These shifts were due to rapid diffusion of knowledge and technology for infectious disease control from high-income to low-inco...

    journal_title:International journal of epidemiology

    pub_type: 杂志文章

    doi:10.1093/ije/dyt122

    authors: Mackenbach JP,Looman CW

    更新日期:2013-08-01 00:00:00