Abstract:
:A proportional mortality study was conducted to determine if state of birth is a risk factor associated with motor neurone disease (MND) and Parkinson's disease (PD) using US death certificate information for 1981. State of birth was used as a surrogate variable for location of early childhood environment. A gradient of risk by geographical area in the US was found for MND and PD. Cerebral vascular accident (CVA) deaths served as a comparison group. Multiple sclerosis (MS) deaths were analysed to validate the methods used. A geographical relationship between latitude proportional mortality ratios for MND, PD and MS by state of birth, and a geographical relationship between latitude and proportional mortality ratios for MND and MS by state of birth were found. Statistical modelling was used to compare the deaths from MND, PD, MS, CVA to all other deaths in the US by state of birth. The resulting models were evaluated to determine if any individual states were not well represented by the model for each disease. As predicted, no pattern was evident for CVA. The geographical gradient observed for MS was as predicted by other studies. The geographical pattern found for MND has a northwest to southeast gradient and the pattern found for PD has a west to east gradient.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Betemps EJ,Buncher CRdoi
10.1093/ije/22.5.898subject
Has Abstractpub_date
1993-10-01 00:00:00pages
898-904issue
5eissn
0300-5771issn
1464-3685journal_volume
22pub_type
杂志文章abstract::Mildmay Uganda (MUg), an HIV treatment centre near Kampala, the capital of Uganda, has entered into a memorandum of understanding to collaborate with Canadian researchers at the University of Ottawa to develop their research programme and develop an observational cohort database (the MUg observational cohort). The pri...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys170
更新日期:2012-12-01 00:00:00
abstract:AIM AND METHODS:To discuss evidence for and against genetic 'causes' of type 2 diabetes, illustrated by standardized study of glucose intolerance and high blood pressure in four representative African origin populations. Comparison of two genetically closer sites: rural (site 1) and urban Cameroon (2); then Jamaica (3)...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.1.111
更新日期:2001-02-01 00:00:00
abstract::The proportion of births to women of New Commonwealth origin in different Area Health Authorities (AHAs) varies widely. The influence of this varying proportion in contributing to differences in perinatal mortality rate (PNMR) between authorities is examined. Firstly, it is shown that the two main 'immigrant' groups h...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/9.3.255
更新日期:1980-09-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Computerized record linkage is commonly used in cohort studies to ascertain the study outcome, and as such its accuracy classifying the outcome can be described using the standard epidemiological terms of sensitivity and positive predictive value (PPV). METHOD:We describe a 'duplicate method' to calculate t...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
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更新日期:2002-12-01 00:00:00
abstract::Two hundred and ninety-nine of 428 patients diagnosed with acute myocardial infarction (AMI) in Kuwait during 1978 were matched with hospitalized controls by sex, nationality, and same year of age. Patients were almost six times as likely as controls to be smokers (odds ratio [OR] = 5.6; 95% confidence limits [CL] = 2...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/11.4.368
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Previous studies on the association between childhood infections and childhood leukaemia have produced inconsistent results, likely due to the recall error/bias of infection data reported by the parents. The current study used a population-based and record-based case-control design to evaluate the associatio...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys113
更新日期:2012-08-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyq207
更新日期:2011-04-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt274
更新日期:2014-06-01 00:00:00
abstract:Background:Mendelian randomization (MR) is being increasingly used to strengthen causal inference in observational studies. Availability of summary data of genetic associations for a variety of phenotypes from large genome-wide association studies (GWAS) allows straightforward application of MR using summary data metho...
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pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ije/dyt227
更新日期:2014-04-01 00:00:00
abstract:MOTIVATION:RVPedigree (Rare Variant association tests in Pedigrees) implements a suite of programs facilitating genome-wide analysis of association between a quantitative trait and autosomal region-based genetic variation. The main features here are the ability to appropriately test for association of rare variants wit...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyw047
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Exposure to respirable crystalline silica is suggested to increase the risk of autoimmune rheumatic diseases. We examined the association between respirable crystalline silica exposure and systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and small vessel vasculitis. METHODS:In a cohort...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa287
更新日期:2021-01-18 00:00:00
abstract::The Shahroud Eye Cohort Study was set up to determine the prevalence and incidence of visual impairment and major eye conditions in the 40-64-year-old population of Shahroud as a Middle Eastern population. The first phase of the study was conducted in 2009-10. Using random cluster sampling, 6311 Shahroud inhabitants w...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys161
更新日期:2013-10-01 00:00:00
abstract::Interest has recently emerged about the increasing trend of pancreatic cancer mortality in Taiwan, particularly in the elderly. The mortality data of pancreatic cancer over the period 1971-1986 for males and females aged 40-84 in Taiwan were analysed using a log-linear Poisson model to examine the effects of age, cale...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.4.839
更新日期:1990-12-01 00:00:00
abstract::The completeness of cancer registration in the IKL (Integraal Kankercentrum Limburg) cancer registry, Limburg, the Netherlands, was evaluated for the years 1988-1990 by means of the independent case ascertainment method. This study was performed in co-operation with the Registration Network of Family Practices (RNFP) ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.3.369
更新日期:1993-06-01 00:00:00
abstract::The diagnosis of Schistosoma haematobium disease on the basis of history and physical examination alone is often difficult. Tests have thus been developed to allow an early and more accurate diagnosis. However these tests have substantial imperfections and many different results obtained from these tests must be integ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.1.202
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:The objective of the study was to estimate the prevalence of gonorrhoea and chlamydial infections and to determine sexual and demographic correlates for these sexually transmitted diseases (STD) among visitors of an STD clinic. METHODS:In 1994, a cross-sectional study was carried out among 2984 consecutive ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.6.1373
更新日期:1997-12-01 00:00:00
abstract::Epidemiologists frequently encounter studies with ordered responses. Standard ordered response logit models, such as the continuation ratio model, constrain exposure to have a homogeneous effect across thresholds of the ordered response. We demonstrate a method for fitting regression models for unconstrained, partiall...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.6.1379
更新日期:2001-12-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.4.756
更新日期:1989-12-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyg100
更新日期:2003-08-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/16.3.472
更新日期:1987-09-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy286
更新日期:2019-02-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.2.426
更新日期:1996-04-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::The paper reports on the trends of induced abortion in Italy since its legalization in 1978. Data collected through the national surveillance system show that the abortion rates and ratios in Italy, after an initial increase, have been stable in the last four years, and are comparable to those of other European countr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/15.3.343
更新日期:1986-09-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa211
更新日期:2020-11-22 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
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更新日期:1988-09-01 00:00:00
abstract::The Themba Lethu Clinical Cohort was established in 2004 to allow large patient-level analyses from a single HIV treatment site to evaluate National Treatment Guidelines, answer questions of national and international policy relevance and to combine an economic and epidemiologic focus on HIV research. The current obje...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys029
更新日期:2013-04-01 00:00:00