Abstract:
BACKGROUND:On the basis of a population-based cohort, we assessed the cancer risk, focusing on gynaecological cancers and pre-malignant lesions, among women with a previous tubal sterilization. METHODS:Using the Danish Hospital Discharge Register we identified 65 232 women who had a tubal sterilization (1977-1993). The cohort was followed for cancer occurrence, and compared with the expected number based on the national cancer incidence rates. RESULTS:The overall risk of ovarian cancer was decreased (standardized incidence ratio [SIR] = 0.82; 95% CI: 0.6, 1.0), and it was still decreased > or =10 years after the sterilization (SIR = 0.65; 95% CI: 0.4, 1.0). The rate of endometrial cancer was also decreased (SIR = 0.66; 95% CI: 0.5, 1.0), the risk continued being moderately reduced during follow-up, although it was not statistically significant. CONCLUSIONS:In this nationwide, population-based study we find that women with tubal sterilization have a decreased risk of subsequent development of ovarian cancer. As the protective effect is not decreasing with years of follow-up, our data do not support that 'screening' bias can explain the protective effect, but indicate that the sterilization itself may convey a reduction in risk. The same pattern is found for endometrial cancer, the association being less strong.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Kjaer SK,Mellemkjaer L,Brinton LA,Johansen C,Gridley G,Olsen JHdoi
10.1093/ije/dyh046keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
596-602issue
3eissn
0300-5771issn
1464-3685pii
dyh046journal_volume
33pub_type
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