当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF EPIDEMIOLOGY期刊下所有文献 > Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight.

Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight.

Abstract：

BACKGROUND:Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is causal. METHODS:We performed two-sample Mendelian randomization (MR) using summary data on associations between genotype-B12 (10 genetic variants) or genotype-folate (four genetic variants) levels from: a genome-wide association study of 45 576 individuals (sample 1); and both maternal- and fetal-specific genetic effects on offspring birthweight from the latest Early Growth Genetics consortium meta-analysis with 297 356 individuals reporting their own birthweight and 210 248 women reporting their offspring's birthweight (sample 2). We used the inverse variance weighted method, and sensitivity analyses to account for pleiotropy, in addition to excluding a potentially pleiotropic variant in the FUT2 gene for B12 levels. RESULTS:We did not find evidence for a causal effect of maternal or fetal B12 levels on offspring birthweight. The results were consistent across the different methods. We found a positive causal effect of maternal folate levels on offspring birthweight [0.146 (0.065, 0.227), which corresponds to an increase in birthweight of 71 g per 1 standard deviation higher folate]. We found some evidence for a small inverse effect of fetal folate levels on their own birthweight [-0.051 (-0.100, -0.003)]. CONCLUSIONS:Our results are consistent with evidence from randomized controlled trials that higher maternal folate levels increase offspring birthweight. We did not find evidence for a causal effect of B12 levels on offspring birthweight, suggesting previous observational studies may have been confounded.

journal_name

Int J Epidemiol

journal_title

International journal of epidemiology

authors

Moen GH,Beaumont RN,Grarup N,Sommer C,Shields BM,Lawlor DA,Freathy RM,Evans DM,Warrington NM

doi

10.1093/ije/dyaa256

subject

Has Abstract

pub_date

2020-12-21 00:00:00

eissn

0300-5771

issn

1464-3685

pii

6042991

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY文献大全
  • Characteristics of women under 20 with cervical intraepithelial neoplasia.

    abstract：:The relationship between risk of cervical neoplasia and various sociodemographic, reproductive and sexual characteristics was studied in 126 women (cases) with an abnormal Papanicolaou test finding and 1914 controls seen at the same clinic in which cases were detected but showing no evidence of cervical neoplasia. All...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/15.4.477

    authors： Zaninetti P,Franceschi S,Baccolo M,Bonazzi B,Gottardi G,Serraino D

    更新日期：1986-12-01 00:00:00

  • Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort.

    abstract：BACKGROUND:Although individual studies have been inconsistent, meta-analyses of epidemiological data suggest that high folate and vitamin B12 levels may be associated with increased prostate cancer risk. METHODS:Within JANUS, a prospective cohort in Norway (n = 317 000) with baseline serum samples, we conducted a nest...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dys199

    authors： de Vogel S,Meyer K,Fredriksen Å,Ulvik A,Ueland PM,Nygård O,Vollset SE,Tell GS,Tretli S,Bjørge T

    更新日期：2013-02-01 00:00:00

  • Development and tracking of central patterns of subcutaneous fat in adolescence and adulthood: the Amsterdam Growth and Health Study.

    abstract：BACKGROUND:A central pattern of body fat is recognized as a risk indicator of cardiovascular diseases in adulthood. The development of this body fat pattern from childhood into adulthood however, remains to be explored. METHODS:The development of two trunk skinfolds (subscapular; supra-iliac), two extremity skinfolds ...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/25.6.1162

    authors： van Lenthe FJ,Kemper HC,van Mechelen W,Twisk JW

    更新日期：1996-12-01 00:00:00

  • Predicting incidence of variant Creutzfeldt-Jakob disease from UK dietary exposure to bovine spongiform encephalopathy for the 1940 to 1969 and post-1969 birth cohorts.

    abstract：BACKGROUND:To investigate variant Creutzfeldt-Jakob disease (vCJD) incubation period, transmission barrier, and short-term vCJD predictions for methionine homozygotes in 1940-1969 and post-1969 birth cohorts by use of gender- and age-specific exposure intensities to bovine spongiform encephalopathy (BSE), based on cons...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dyg248

    authors： Cooper JD,Bird SM

    更新日期：2003-10-01 00:00:00

  • Effects of different designs and extension of a food frequency questionnaire on response rate, completeness of data and food frequency responses.

    abstract：:The authors studied how the introduction of several modifications to a basic food frequency questionnaire can influence the results of dietary surveys. Modifications covered eight combinations based on three levels: increasing versus decreasing order of frequency categories; questionnaires without versus with question...

    journal_title：International journal of epidemiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ije/21.6.1144

    authors： Kuskowska-Wolk A,Holte S,Ohlander EM,Bruce A,Holmberg L,Adami HO,Bergstrom R

    更新日期：1992-12-01 00:00:00

  • Dietary patterns and the risk of mortality: impact of cardiorespiratory fitness.

    abstract：BACKGROUND:While dietary patterns that are both predictive of chronic disease and mortality have been identified, the confounding effects of cardiorespiratory fitness have not been properly addressed. The primary objective was to assess the relation between dietary patterns with all-cause mortality, while controlling f...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dyp191

    authors： Héroux M,Janssen I,Lam M,Lee DC,Hebert JR,Sui X,Blair SN

    更新日期：2010-02-01 00:00:00

  • A case-control study of paternal smoking and birth defects.

    abstract：:Although the influence of paternal smoking on birth defects is of great public interest, epidemiological evidence concerning this potential relationship is extremely limited. A stratified random sample of 29 hospitals in the Shanghai Municipality, China, was used to select 1012 birth defects cases and controls. Mother...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/21.2.273

    authors： Zhang J,Savitz DA,Schwingl PJ,Cai WW

    更新日期：1992-04-01 00:00:00

  • A comparison of sisterhood information on causes of maternal death with the registration causes of maternal death in Matlab, Bangladesh.

    abstract：BACKGROUND:To explore whether causes of maternal death can be investigated using the sisterhood method, an indirect method for providing a community-based estimate of the level of maternal mortality, this study compares the sisterhood causes of maternal death with the Matlab Demographic Surveillance System's (DSS) caus...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/24.5.937

    authors： Shahidullah M

    更新日期：1995-10-01 00:00:00

  • Alcohol consumption and all-cause mortality.

    abstract：BACKGROUND:Prospective studies of alcohol and mortality in middle-aged men almost universally find a U-shaped relationship between alcohol consumption and risk of mortality. This review demonstrates the extent to which different studies lead to different risk estimates, analyses the putative influence of abstention as ...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章,评审

    doi：10.1093/ije/24.1.100

    authors： Duffy JC

    更新日期：1995-02-01 00:00:00

  • Water supply, sanitation and diarrhoeal disease in Nicaragua: results from a case-control study.

    abstract：:A case-control study of risk factors for child diarrhoeal disease was undertaken in a rural area of Nicaragua. Some 1229 children under the age of five were matched with an equal number of children of the same age presenting with other illnesses unrelated to water and sanitation. The main types of water supply were sa...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/20.2.527

    authors： Gorter AC,Sandiford P,Smith GD,Pauw JP

    更新日期：1991-06-01 00:00:00

  • Hypertension and sources of blood pressure variability among Mexican-Americans in Starr County, Texas.

    abstract：:Previous investigations have established that the Mexican-American community of south Texas has a three- to five-fold elevated risk for non-insulin dependent diabetes mellitus when compared to the US population as a whole. In addition, evidence points to similarly increased risks of the related disorders, hypertension...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/14.2.231

    authors： Hanis CL,Ferrell RE,Schull WJ

    更新日期：1985-06-01 00:00:00

  • Dairy, soy, and risk of breast cancer: those confounded milks.

    abstract：BACKGROUND:Associations between soy, dairy intakes and breast cancer risk are inconsistent. No studies exist with large numbers of dairy consumers and soy consumers to assess mutual confounding. METHODS:The study cohort contains 52 795 North American women, initially free of cancer, followed for 7.9 years (29.7% were ...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dyaa007

    authors： Fraser GE,Jaceldo-Siegl K,Orlich M,Mashchak A,Sirirat R,Knutsen S

    更新日期：2020-10-01 00:00:00

  • When aspirations and achievements don't meet. A longitudinal examination of the differential effect of education and occupational attainment on declines in self-rated health among Canadian labour force participants.

    abstract：BACKGROUND:To examine the association of a mismatch between educational qualifications and occupational attainment and subsequent declines in self-rated health (SRH) in a longitudinal nationally representative Canadian population sample. METHODS:This study used longitudinal data from 4045 healthy, working respondents ...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dyi047

    authors： Smith P,Frank J

    更新日期：2005-08-01 00:00:00

  • Short-term and long-term reproducibility of dietary history interview data.

    abstract：:This study gives results for comparisons between dietary history interviews repeated at short-term (4-8 months) and long-term (4-7 years) intervals in conjunction with the Finnish Mobile Clinic Health Examination Survey. Interviews surveying the whole range of consumable foods over the preceding year were completed in...

    journal_title：International journal of epidemiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ije/22.3.520

    authors： Järvinen R,Seppänen R,Knekt P

    更新日期：1993-06-01 00:00:00

  • Ethnic factors in multiple sclerosis: a review and critique of the epidemiological literature.

    abstract：:A review of the international epidemiological literature is undertaken with the view of identifying the main demographic and sociocultural features of MS as they apply to ethnic groups. Ethnic groups are differentiated principally in terms of three variables: race, religion, and nationality. Although MS is present in ...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章,评审

    doi：10.1093/ije/17.1.14

    authors： Lowis GW

    更新日期：1988-03-01 00:00:00

  • Heat wave characteristics, mortality and effect modification by temperature zones: a time-series study in 130 counties of China.

    abstract：BACKGROUND:The substantial disease burden attributed to heat waves, and their increasing frequency and intensity due to climate change, highlight the importance of understanding the health consequences of heat waves. We explore the mortality risk due to heat wave characteristics, including the timing in the seasons, th...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dyaa104

    authors： Sun Z,Chen C,Yan M,Shi W,Wang J,Ban J,Sun Q,He MZ,Li T

    更新日期：2021-01-23 00:00:00

  • An ecologic study of protective equipment and injury in two contact sports.

    abstract：BACKGROUND:Contact sports have high rates of injury. Protective equipment regulations are widely used as an intervention to reduce injury risk. The purpose of this study was to investigate the injury prevention effect of regulations governing protective equipment in two full-body contact sports. METHODS:Injury rates i...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章,多中心研究

    doi：10.1093/ije/31.3.587

    authors： Marshall SW,Waller AE,Dick RW,Pugh CB,Loomis DP,Chalmers DJ

    更新日期：2002-06-01 00:00:00

  • A box-graph method for illustrating relative-size relationships in a 2 x 2 table.

    abstract：:The proportional relationships of the four numbers in a 2 x 2 table can be displayed using two types of box graphs. In one approach, a 'unitary square' is first divided according to the denominator proportions of the two groups formed in a cohort or case-control study, and then re-divided according to the numerator pr...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/17.1.222

    authors： Feinstein AR,Kwoh CK

    更新日期：1988-03-01 00:00:00

  • Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis.

    abstract：Background:To assess the worldwide variation of amyotrophic lateral sclerosis (ALS) incidence, we performed a systematic review and meta-analysis of population-based data published to date. Methods:We reviewed Medline and Embase up to June 2015 and included all population-based studies of newly diagnosed ALS cases, us...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1093/ije/dyw061

    authors： Marin B,Boumédiene F,Logroscino G,Couratier P,Babron MC,Leutenegger AL,Copetti M,Preux PM,Beghi E

    更新日期：2017-02-01 00:00:00

  • Change in smoking status among a cohort of late adolescents: prediction and explanation of initiation, maintenance and cessation.

    abstract：:This study examined the degree and type of changes in adolescent smoking status that occurred over an eight-year period, when the group was in grades four to six, to late adolescence and early adulthood. Where changes in smoking occurred, they were more likely to be in the direction of increased (57.7%), as compared t...

    journal_title：International journal of epidemiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ije/15.4.519

    authors： Pederson LL,Lefcoe NM

    更新日期：1986-12-01 00:00:00

  • Influence of heavy agricultural work during pregnancy on birthweight in northeast Brazil.

    abstract：BACKGROUND:Women in developing countries often continue their agricultural work during late pregnancy. Whether this adversely affects birthweight is not clear from previous studies as few controlled for confounding factors. This study seeks to clarify this issue. METHODS:This retrospective cohort study investigated 95...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/28.3.469

    authors： Lima M,Ismail S,Ashworth A,Morris SS

    更新日期：1999-06-01 00:00:00

  • Seroepidemiological survey of human T-lymphotropic retrovirus among indigenous populations in Taiwan.

    abstract：:The prevalence of human T-lymphotropic retrovirus (HTLV) was examined in Taiwan's indigenous populations. In all, 797 healthy subjects in Taiwan including Han Chinese and nine indigenous populations (Ami, Atayal, Bunun, Saisiat, Paiwan, Puyuma, Rukai, Tsuo, and Yami) were examined for the presence of antibodies to HTL...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/22.5.927

    authors： Ishida T,Pan IH,Horai S,Saitou N,Sun CS

    更新日期：1993-10-01 00:00:00

  • Child survival in Beirut during wartime: time trends and socio-religious differentials.

    abstract：BACKGROUND:Child mortality estimates in Beirut are presented for the late 1970s and the mid 1980s, and changes in socio-religious differentials of mortality across time are investigated. METHODS:Baseline information was obtained from maternity registries in Beirut in 1984 and 1991. Age of mother, number of children ev...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/26.1.110

    authors： Deeb M,Khlat M,Courbage Y

    更新日期：1997-02-01 00:00:00

  • Are cities good for health? A study of the impacts of planned urbanization in China.

    abstract：BACKGROUND:Urbanization in developing countries is usually accompanied by migration to cities, making it a challenge to unpack the independent relationships between migration, urbanization and health, particularly in the presence of health-selective migration. Since 1978, unprecedented planned urbanization has taken pl...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dyz031

    authors： Hou B,Nazroo J,Banks J,Marshall A

    更新日期：2019-08-01 00:00:00

  • The current scope of healthcare-associated infection surveillance activities in hospitalized immunocompromised patients: a systematic review.

    abstract：BACKGROUND:Immunocompromised patients are at increased risk of acquiring healthcare-associated infections (HAIs) and often require specialized models of care. Surveillance of HAIs is essential for effective infection-prevention programmes. However, little is known regarding standardized or specific surveillance methods...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dyz162

    authors： Valentine JC,Hall L,Verspoor KM,Worth LJ

    更新日期：2019-12-01 00:00:00

  • Mortality in two Jewish populations--Montreal and Israel: environmental determinants of differences.

    abstract：BACKGROUND:Mortality was compared in the Jewish populations of Montreal and Israel and the overall Canadian population, to investigate whether the Israeli pattern of low male mortality and relatively high female mortality is replicated among Jews living elsewhere. METHODS:In Montreal, death certificates were obtained ...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/24.4.730

    authors： Shatenstein B,Kark JD

    更新日期：1995-08-01 00:00:00

  • Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts.

    abstract：Background:The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth coho...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dyy081

    authors： Yokoyama Y,Jelenkovic A,Hur YM,Sund R,Fagnani C,Stazi MA,Brescianini S,Ji F,Ning F,Pang Z,Knafo-Noam A,Mankuta D,Abramson L,Rebato E,Hopper JL,Cutler TL,Saudino KJ,Nelson TL,Whitfield KE,Corley RP,Huibregtse BM,

    更新日期：2018-08-01 00:00:00

  • Association between adult height, genetic susceptibility and risk of glioma.

    abstract：BACKGROUND:Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modi...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章,多中心研究

    doi：10.1093/ije/dys114

    authors： Kitahara CM,Wang SS,Melin BS,Wang Z,Braganza M,Inskip PD,Albanes D,Andersson U,Beane Freeman LE,Buring JE,Carreón T,Feychting M,Gapstur SM,Gaziano JM,Giles GG,Hallmans G,Hankinson SE,Henriksson R,Hsing AW,Johansen C

    更新日期：2012-08-01 00:00:00

  • Twinning following oral contraceptive discontinuation.

    abstract：:The characteristics of 673 mothers of twins were compared to those of a matched sample of mothers of singletons. Both groups of mothers were interviewed just after delivery, and births in each group were matched for time and place. Of the characteristics studied, the use of oral contraceptives (OC) displayed a signifi...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/10.4.319

    authors： Hemon D,Berger C,Lazar P

    更新日期：1981-12-01 00:00:00

  • Resting heart rate on the decline: the Tromsø Study 1986-2007.

    abstract：BACKGROUND:We examined secular changes in resting heart rate (RHR) and their relationship with changes in other cardiovascular risk factors in adult men and women over a 22-year period. METHODS:A single-centre population-based longitudinal study comprised 30,699 men and women aged 30-89 years who participated in at le...

    journal_title：International journal of epidemiology

    pub_type： 杂志文章

    doi：10.1093/ije/dyv061

    authors： Sharashova E,Wilsgaard T,Brenn T

    更新日期：2015-06-01 00:00:00