Abstract:
Background:To assess the worldwide variation of amyotrophic lateral sclerosis (ALS) incidence, we performed a systematic review and meta-analysis of population-based data published to date. Methods:We reviewed Medline and Embase up to June 2015 and included all population-based studies of newly diagnosed ALS cases, using multiple sources for case ascertainment. ALS crude and standardized incidence (on age and sex using the US 2010 population) were calculated. Random effect meta-analysis and meta-regression were performed using the subcontinent as the main study level covariate. Sources of heterogeneity related to the characteristics of the study population and the study methodology were investigated. Results:Among 3216 records, 44 studies were selected, covering 45 geographical areas in 11 sub-continents. A total of 13 146 ALS cases and 825 million person-years of follow-up (PYFU) were co-nsidered. The overall pooled worldwide crude ALS incidence was at 1.75 (1.55-1.96)/100 000 PYFU; 1.68 (1.50-1.85)/100 000 PYFU after standardization. Heterogeneity was identified in ALS standardized incidence between North Europe [1.89 (1.46-2.32)/100 000 PYFU] and East Asia [0.83 (0.42-1.24)/100 000 PYFU, China and Japan P = 0.001] or South Asia [0.73 (0.58-0.89)/100 000/PYFU Iran, P = 0.02]. Conversely, homogeneous rates have been reported in populations from Europe, North America and New Zealand [pooled ALS standardized incidence of 1.81 (1.66-1.97)/100 000 PYFU for those areas]. Conclusion:This review confirms a heterogeneous distribution worldwide of ALS, and sets the scene to sustain a collaborative study involving a wide international consortium to investigate the link between ancestry, environment and ALS incidence.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Marin B,Boumédiene F,Logroscino G,Couratier P,Babron MC,Leutenegger AL,Copetti M,Preux PM,Beghi Edoi
10.1093/ije/dyw061subject
Has Abstractpub_date
2017-02-01 00:00:00pages
57-74issue
1eissn
0300-5771issn
1464-3685pii
dyw061journal_volume
46pub_type
杂志文章,meta分析,评审abstract::The effect of misclassification by one-, two-, or seven-day food records on the apparent magnitude of results was quantified for two hypothetical models of association of diet with disease. For each of 106 women, classification to quintiles of intake was calculated from 37 to 72 one-day records and compared to classif...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.1.232
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:A growing body of literature suggests that physical activity may be a protective factor against hip fracture. METHODS:To study the association between hip fracture risk and recreational physical activity at various ages, changes in activity during adult life, occupational physical activity and how risks var...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/29.2.308
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:The substantial disease burden attributed to heat waves, and their increasing frequency and intensity due to climate change, highlight the importance of understanding the health consequences of heat waves. We explore the mortality risk due to heat wave characteristics, including the timing in the seasons, th...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa104
更新日期:2021-01-23 00:00:00
abstract::The role of rotavirus in non-bacterial gastroenteritis in Kuwait was investigated. Employing electronmicroscopy (EM) and enzyme-linked-immuno-sorbent-assay (ELISA) techniques, the virus was detected in the stools of 42 of 274 (15.3%) infants with the disease. A statistically significant association (P less than 0.05) ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/9.4.355
更新日期:1980-12-01 00:00:00
abstract::This paper argues that the perspective of economics is valuable in assessing the desirability, purpose and effectiveness of public intervention to reduce occupational accidents and diseases and suggests that the concept of efficiency provides one (although not the only) important criterion by which to judge policy in ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/12.1.77
更新日期:1983-03-01 00:00:00
abstract:OBJECTIVE:To investigate the association between poverty, birthweight, and infant weight gain in Hertfordshire, 1923-1939. DESIGN:Cohort study based on the Hertfordshire Health Visitors' Register (HHVR). SETTING:The population of Hertfordshire, and a sub-sample of five Hertfordshire towns-Hoddesdon, Berkhampstead, He...
journal_title:International journal of epidemiology
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doi:10.1093/ije/dyh226
更新日期:2004-12-01 00:00:00
abstract::Aetiology confronts two distinct issues: the determinants of individual cases, and the determinants of incidence rate. If exposure to a necessary agent is homogeneous within a population, then case/control and cohort methods will fail to detect it: they will only identify markers of susceptibility. The corresponding s...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.1.32
更新日期:1985-03-01 00:00:00
abstract::Seemingly contradictory data support controversies concerning the relationships between food intake and illnesses. The present study of 1035 adults, aged 30-39 years, shows that (1) daily energy intake is not higher in obese than in non-obese people, (2) obesity is more prevalent in social groups where energy intake i...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.3.571
更新日期:1990-09-01 00:00:00
abstract::This paper describes a means of analysing the effects that the benefit of early treatment, lead time and length-biased sampling (and other forms of prognostic selection bias) have on the mortality rate of cases detected in screening programmes. Both benefit and lead time reduce the mortality rate of screen-detected ca...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/11.3.261
更新日期:1982-09-01 00:00:00
abstract::Despite the extreme differences in the incidence of lung cancer between black and white Americans of each sex, little information is available on the sex-race-specific lung cancer risk due to tobacco use. In the current study, case-control data were examined for sex-race differences in the lung cancer risk associated ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.4.592
更新日期:1993-08-01 00:00:00
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journal_title:International journal of epidemiology
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doi:10.1093/ije/dys151
更新日期:2012-12-01 00:00:00
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/ije/4.3.159
更新日期:1975-09-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.supplement_1.s90
更新日期:1995-01-01 00:00:00
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更新日期:2019-04-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dym085
更新日期:2007-08-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyw098
更新日期:2017-02-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy007
更新日期:2018-06-01 00:00:00
abstract::In the Zutphen Study data were collected on occupation, smoking habits, blood pressure, serum cholesterol, height and weight of 856 men who were 40-59 years old in 1960. Between 1960 and 1985 detailed information was collected on mortality. The effect of socioeconomic status as indicated by occupation on 25-year morta...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.3.658
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Debates exist over whether health inequities are bound to rise as population health improves, due to health improving more quickly among the better off, with most analyses focused on mortality data. METHODS:We analysed 50 years of socioeconomic inequities in measured health status among US-born Black and Wh...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyu047
更新日期:2014-08-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/26.3.551
更新日期:1997-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/ije/dyq072
更新日期:2010-10-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.6.1262
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Despite abundant evidence that lower education is associated with a higher risk of smoking, whether the association is causal has not been convincingly established. METHODS:We investigated the association between education and lifetime smoking patterns in a birth cohort established in 1959 and followed thro...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dym250
更新日期:2008-06-01 00:00:00
abstract::John Snow was a genius in epidemiology. His achievement was to evolve an elegant, internally and externally consistent theory which concerned the mechanisms and processes involved in every aspect of the subject he had chosen to study. In order to do this he did not restrict himself to any method. He used all skills av...
journal_title:International journal of epidemiology
pub_type: 传,历史文章,杂志文章
doi:10.1093/ije/12.4.393
更新日期:1983-12-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.2.456
更新日期:1991-06-01 00:00:00
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journal_title:International journal of epidemiology
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更新日期:1996-04-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1991-12-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/20.2.527
更新日期:1991-06-01 00:00:00
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journal_title:International journal of epidemiology
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doi:10.1093/ije/6.3.203
更新日期:1977-09-01 00:00:00