Abstract：
:Although the content of histamine in myocardial tissue is high, its contribution to the regulation of coronary blood flow has not been clearly defined. The aim of the present study was to investigate whether or not nitric oxide (NO), an important modulator of coronary vascular tone, is involved in histamine-induced coronary vasomotion and to characterize which histaminergic receptor subtype mediates this process. Isolated, constant-flow-perfused guinea pig hearts were challenged with histamine, the H1-receptor agonist pyridylethylamine (PYR) and the H2-receptor agonist dimaprit (DIM). Apart from coronary perfusion pressure (CPP), left ventricular pressure (LVP) and the development of contractile force (dp/dt), the release of NO and cyclic GMP (cGMP) were continuously measured. Histamine and DIM induced concentration dependently a coronary vasodilatation with an almost 50% decrease in CPP paralleled by an enhancement of LVP and dp/dt by more than 80%. PYR selectively reduced CPP by 47% without affecting LVP and dp/dt. Histamine- and PYR-induced coronary vasodilatation were paralleled by a more-than-twofold increase in basal cGMP release from isolated hearts, whereas DIM exerted no effects on cGMP release. Oxyhemoglobin (4 microM), an effective scavenger of NO, shifted the concentration-response curve for histamine- and PYR-induced changes in CPP significantly to the right and in parallel inhibited the increase in cGMP release. Histamine and PYR rapidly (within 2 s) decreased CPP, while the onset of DIM-induced coronary vasodilatation followed changes in LVP with a lag period of 10 s. Histamine increased basal NO release concentration dependently by a maximum of 351 +/- 21 pmol/min.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Vasc Resjournal_title
Journal of vascular researchauthors
Kelm M,Feelisch M,Krebber T,Motz W,Strauer BEdoi
10.1159/000158987subject
Has Abstractpub_date
1993-05-01 00:00:00pages
132-8issue
3eissn
1018-1172issn
1423-0135journal_volume
30pub_type
杂志文章abstract：:During the early stage of angiogenesis, neovascular sprouts are composed primarily of endothelial cells. As they mature, microvessels acquire a coating of mural cells, which are critical for the development and maintenance of a functional vasculature. Though growth factor regulation of mural cell recruitment has been ...
journal_title：Journal of vascular research
pub_type： 杂志文章
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abstract：:Insulin was reported to decrease Na(+)/H(+) exchange activity in murine vascular smooth muscle (VSM) tissue. In most other cells, insulin increases activity. We tested the effects of insulin on Na(+)/H(+) exchange activity in primary cultured canine VSM cells. Intracellular pH (pH(i)) was measured with 2',7'-bis(2-car...
journal_title：Journal of vascular research
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journal_title：Journal of vascular research
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journal_title：Journal of vascular research
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doi：10.1159/000181545
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journal_title：Journal of vascular research
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更新日期：1995-11-01 00:00:00
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journal_title：Journal of vascular research
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000158980
更新日期：1993-03-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000158972
更新日期：1993-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000159134
更新日期：1996-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000158951
更新日期：1992-09-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000194269
更新日期：2009-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000448713
更新日期：2016-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000159196
更新日期：1997-01-01 00:00:00
abstract：:Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins of the TNF/interleukin (IL)-1/Toll-like receptor superfamily. Ligands of this family such as TNFα, CD40L, and IL-1β promote chronic inflammatory processes such as atherosclerosis and restenosis, the latter being a common a...
journal_title：Journal of vascular research
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000097892
更新日期：2007-01-01 00:00:00
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journal_title：Journal of vascular research
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更新日期：1997-05-01 00:00:00
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更新日期：2011-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
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更新日期：2003-09-01 00:00:00
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journal_title：Journal of vascular research
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journal_title：Journal of vascular research
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journal_title：Journal of vascular research
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Journal of vascular research
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doi：10.1159/000051041
更新日期：2001-03-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000051081
更新日期：2001-09-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000320356
更新日期：2011-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000098153
更新日期：2007-01-01 00:00:00
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journal_title：Journal of vascular research
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journal_title：Journal of vascular research
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000025733
更新日期：2000-05-01 00:00:00
